RNAVIRUSPOPDIVNVAX

"RNA virus population diversity, virulence, attenuation and vaccine development."

Coordinatore	INSTITUT PASTEUR    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	France [FR]
Totale costo	1˙870˙000 €
EC contributo	1˙870˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-StG
Funding Scheme	ERC-SG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-10-01   -   2015-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Dr. Nome: Marco Cognome: Vignuzzi Email: send email Telefono: -45688210	FR (PARIS CEDEX 15)	hostInstitution	1˙870˙000.00
2	INSTITUT PASTEUR  Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Ms. Nome: Marie-Laure Cognome: Rosso Email: send email Telefono: 33144389526 Fax: +33 140613940	FR (PARIS CEDEX 15)	hostInstitution	1˙870˙000.00

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 Obiettivo del progetto (Objective)

'RNA viruses have the highest mutation frequencies in nature, which are in large part attributed to the low fidelity of their viral RNA-dependent RNA polymerases (RdRp). Explosive replication kinetics coupled with high mutation rates quickly generate highly diverse populations that have been observed for all RNA viruses. Recently, we have developed a model system to study the roles that RNA virus mutation rates and population heterogeneity play in virus fitness, virulence and pathogenesis in vivo. The system relies on altering the RdRp fidelity of poliovirus, thereby changing the amount of genetic diversity present in a population. We found that increasing or decreasing genetic diversity strongly attenuates the virus and may constitute a novel strategy to engineer live virus vaccines. However, the poliovirus infection model of transgenic mice presents significant limitations that do not permit more detailed studies of the mechanisms behind these observations. To further extend our preliminary results, we will develop two new infection models, to study the role of genetic diversity and population dynamics of RNA viruses infecting their hosts naturally. These models will be used to uncover the mechanisms by which genetic diversity is generated, the points in infection when it is critical and the specific bottlenecking events or subpopulations that are involved at these critical points. We will use new deep sequencing technology, coupled to concepts in population genetics, to develop new strategies for vaccine discovery based on the modulation of RNA virus populations.'