PLANTSYSMODEL

Integrating modeling into plant systems biology: Applications to auxin-driven plant morphogenesis

Coordinatore	more  Organization address address: Science Park 123 city: AMSTERDAM postcode: 1098XG contact info Titolo: Ms. Nome: Margriet Cognome: Brouwer Email: send email Telefono: +31 20 5924253 Fax: +31 20 592 4199
Nazionalità Coordinatore	Non specificata
Totale costo	45˙000 €
EC contributo	45˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-ERG-2008
Funding Scheme	MC-ERG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-09-01   -   2011-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	STICHTING CENTRUM VOOR WISKUNDE EN INFORMATICA  Organization address address: Science Park 123 city: AMSTERDAM postcode: 1098XG contact info Titolo: Ms. Nome: Margriet Cognome: Brouwer Email: send email Telefono: +31 20 5924253 Fax: +31 20 592 4199	NL (AMSTERDAM)	coordinator	45˙000.00

Mappa

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 Obiettivo del progetto (Objective)

'Plant science is evolving from a reductionistic view on gene function to an integrated systems biology approach. Gene function of genes is now studied in the context of the dynamic behavior of physiological, cellular or developmental processes. Mathematical and computational modeling play a central role in this approach. During the initial Marie Curie Fellowship, I worked as a biomodeller at the primarily experimental VIB Department of Plant Systems Biology (PSB) in Ghent, Belgium. Based on this work, PSB has awarded me a “Young Leader” position, which includes a five year position as a group leader and budget for a PhD student. In this position, I have started up the group “Plant Systems Modeling” that is currently composed of myself (PI), a postdoc, three PhD students, and two Master’s students. The European Reintegration Grant would support further development of this group and thus ensure full reintegration. The Plant Systems Modeling group aims to build predictive models of auxin-driven tissue morphogenesis that can act as hypothesis-generators for wet-lab research. The project consists of the following two work packages: WP 1 To predict from first principles the spatio-temporal expression patterns of the major players of early vascular patterning in Arabidopsis, including PIN, AUX and auxin. This model will extend on the traveling-wave mechanism for auxin canalization that we have proposed recently (Merks et al, Trends in Plant Science, 2007). WP 2 To unravel the molecular mechanisms behind the recent observation that auxin oscillations regulate lateral root initiation (De Smet et al., Development 2007). For this we will develop a growing, multicellular model of auxin-flux-regulated patterning in the root basal meristem.'

Introduzione (Teaser)

Auxin is a key hormone in the plant world, and its many functions include arrangement of the leaves on the stem, root growth and flower development. Plantsysmodel, an EU project has provided further information on the system's role of auxin using computational modelling.