SCANCER

Specialized cantilevers for cancer research

Coordinatore	CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT    more  Organization address address: RUE JAQUET DROZ 1 city: NEUCHATEL postcode: 2007 contact info Titolo: Dr. Nome: Martha Cognome: Liley Email: send email Telefono: +41 32 720 5184 Fax: +41 32 720 5740
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	263˙296 €
EC contributo	263˙296 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IOF-2008
Funding Scheme	MC-IOF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-03-01   -   2014-05-19

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT  Organization address address: RUE JAQUET DROZ 1 city: NEUCHATEL postcode: 2007 contact info Titolo: Dr. Nome: Martha Cognome: Liley Email: send email Telefono: +41 32 720 5184 Fax: +41 32 720 5740	CH (NEUCHATEL)	coordinator	263˙296.70

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 Obiettivo del progetto (Objective)

'Research in the mechanical properties of cells will help to develop novel techniques and methods to complement traditional methods of cancer detection and means to evaluate the efficiency of cancer drugs. The objective of this project is to achieve significant advances in such field using specific cantilevers with customized geometries, added functionalities and engineered tips. More concretely, the tip shapes will be chosen in order to increase the contact area and therefore increasing the signal to noise ratio at the moment of the indentation; the geometries of the levers (top-view design) will be improved in order to minimize the damping; and finally a self actuation mechanism will be integrated in the levers in order to minimize the fluid vibrations and therefore the noise. Finally the fabrication and use of arrays of optimized probes is planned aiming the increase of the data acquisition rate, which will enable statistical studies to consolidate the technique and the possibility of the commercialization of the prototypes All the improvements planned for the project are expected to help the development of instruments and methods to ultimately characterize cancer cells in vivo, which is the major goal within cancer detection research. The presented proposal describes an ambitious project in a crucial topic. It will start with a very basic research on cell-studies and characterization with single AFM probes and it will finish with the use of multiple probes in parallel to validate the technique. The synergies between the outgoing and return organizations and the matching of the applicant profile with the research program are optimum for a successful development of the project.'