SPEDOC

Surface Plasmon early Detection and Treatment Follow -up of Circulating Heat Shock Proteins and Tumor Cells

Coordinatore	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES    more  Organization address address: Avinguda Carl Friedrich Gauss 3 city: Castelldefels postcode: 8860 contact info Titolo: Ms. Nome: Dolors Cognome: Mateu Email: send email Telefono: +34 93 553 4175 Fax: 34935534000
Nazionalità Coordinatore	Spain [ES]
Totale costo	2˙496˙000 €
EC contributo	1˙900˙000 €
Programma	FP7-ICT Specific Programme "Cooperation": Information and communication technologies
Code Call	FP7-ICT-2009-4
Funding Scheme	CP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2013-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES  Organization address address: Avinguda Carl Friedrich Gauss 3 city: Castelldefels postcode: 8860 contact info Titolo: Ms. Nome: Dolors Cognome: Mateu Email: send email Telefono: +34 93 553 4175 Fax: 34935534000	ES (Castelldefels)	coordinator	0.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: RUE MICHEL -ANGE city: PARIS postcode: 75794 contact info Titolo: Mr. Nome: Michel Cognome: Mauvais Email: send email Telefono: 33383856013 Fax: 33383252381	FR (PARIS)	participant	0.00
3	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Olivier Cognome: Martin Email: send email Telefono: +41 21 693 26 07 Fax: +41 21 693 26 14	CH (LAUSANNE)	participant	0.00
4	Imagine Optic Spain S.L.  Organization address address: Norte city: Sant Just Desvern postcode: 8960 contact info Titolo: Mr. Nome: Rafael Cognome: PORCAR GUEZENEC Email: send email Telefono: +34 93553 4148 Fax: +34 93553 4000	ES (Sant Just Desvern)	participant	0.00
5	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Dr. Nome: Gilles Cognome: Block Email: send email Telefono: +33 03 88108633 Fax: +33 03 88108175	FR (PARIS)	participant	0.00
6	UNIVERSITE DE BOURGOGNE  Organization address address: Maison de l'Universite - Esplanade Erasme city: DIJON CEDEX postcode: 21078 contact info Titolo: Ms. Nome: CRISTINA Cognome: BRUN Email: send email Telefono: +33 3 80 39 91 21 Fax: +33 3 80 39 37 84	FR (DIJON CEDEX)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

Cancer causes an increased expression of Heat Shock Protein HSP70 in the peripheral blood, at the surface of, and in cancer cells as a result of different sources of stress, including anti-cancer treatments. It was recently demonstrated that tumorigenicity, metastatic potential and resistance to chemotherapy correlated with an increased of expressed HSP70 in cancer cells. On the contrary, HSP70 depletion using combinatorial small peptides called peptide aptamers sensitizes cancer cells to die and could help in cancer therapy.nThe core goal of this project is to combine the latest advances of nano-optics, optical manipulation and microfluidics with the ultimate understanding of HSP70 to develop a novel integrated and ultra sensitive sensing platform for early cancer detection. An early detection would benefit to traditional but also new cancer therapies based on peptide aptamers which could be delivered sooner and at lower doses. The planned sensing device, based on surface plasmon resonances supported by micro and nano-structures, will operate in a microfluidic circuit to minimize the volumes of analytes and increase reproducibility. Enhanced and confined plasmonic fields will be engineered at the nanoscale to implement two main sensing schemes: (i) ultra sensitive tracking of HSP70 proteins circulating in the peripheral blood based on resonance shift induced by specific protein/receptor binding, (ii) individual cell optical trapping (exploiting latest generation of plasmonics tweezers) combined with scattering imaging and Surface Enhanced Raman Scattering to monitor the concentration of HSP70 proteins at the membrane surface and achieve systematic cancer cell screening. These transduction mechanisms and plasmonic tweezers will be integrated into a compact platform to operate in a biological laboratory environment. Such a portable device should be seen as a precursor of a future device enabling point of care diagnostics in a medical environment and leading to individualized therapy.