SPEDOC
Surface Plasmon early Detection and Treatment Follow -up of Circulating Heat Shock Proteins and Tumor Cells
| Coordinatore | FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Organization address
address: Avinguda Carl Friedrich Gauss 3 contact info |
| Nazionalità Coordinatore | Spain [ES] |
| Totale costo | 2˙496˙000 € |
| EC contributo | 1˙900˙000 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2009-4 |
| Funding Scheme | CP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-01-01 - 2013-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Organization address
address: Avinguda Carl Friedrich Gauss 3 contact info |
ES (Castelldefels) | coordinator | 0.00 |
| 2 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: RUE MICHEL -ANGE contact info |
FR (PARIS) | participant | 0.00 |
| 3 |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
CH (LAUSANNE) | participant | 0.00 |
| 4 |
Imagine Optic Spain S.L.
Organization address
address: Norte contact info |
ES (Sant Just Desvern) | participant | 0.00 |
| 5 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | participant | 0.00 |
| 6 |
UNIVERSITE DE BOURGOGNE
Organization address
address: Maison de l'Universite - Esplanade Erasme contact info |
FR (DIJON CEDEX) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
Cancer causes an increased expression of Heat Shock Protein HSP70 in the peripheral blood, at the surface of, and in cancer cells as a result of different sources of stress, including anti-cancer treatments. It was recently demonstrated that tumorigenicity, metastatic potential and resistance to chemotherapy correlated with an increased of expressed HSP70 in cancer cells. On the contrary, HSP70 depletion using combinatorial small peptides called peptide aptamers sensitizes cancer cells to die and could help in cancer therapy.nThe core goal of this project is to combine the latest advances of nano-optics, optical manipulation and microfluidics with the ultimate understanding of HSP70 to develop a novel integrated and ultra sensitive sensing platform for early cancer detection. An early detection would benefit to traditional but also new cancer therapies based on peptide aptamers which could be delivered sooner and at lower doses. The planned sensing device, based on surface plasmon resonances supported by micro and nano-structures, will operate in a microfluidic circuit to minimize the volumes of analytes and increase reproducibility. Enhanced and confined plasmonic fields will be engineered at the nanoscale to implement two main sensing schemes: (i) ultra sensitive tracking of HSP70 proteins circulating in the peripheral blood based on resonance shift induced by specific protein/receptor binding, (ii) individual cell optical trapping (exploiting latest generation of plasmonics tweezers) combined with scattering imaging and Surface Enhanced Raman Scattering to monitor the concentration of HSP70 proteins at the membrane surface and achieve systematic cancer cell screening. These transduction mechanisms and plasmonic tweezers will be integrated into a compact platform to operate in a biological laboratory environment. Such a portable device should be seen as a precursor of a future device enabling point of care diagnostics in a medical environment and leading to individualized therapy.