SYSBIOFILM

Systems biology of Pseudomonas aeruginosa in biofilms

 Coordinatore HASKOLI ISLANDS 

 Organization address address: Sudurgata
city: REYKJAVIK
postcode: IS 101

contact info
Titolo: Prof.
Nome: Sigurdur
Cognome: Brynjolfsson
Email: send email
Telefono: +354 525 4641
Fax: +354 525 4632

 Nazionalità Coordinatore Iceland [IS]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-RG
 Funding Scheme MC-IRG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-03-01   -   2014-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    HASKOLI ISLANDS

 Organization address address: Sudurgata
city: REYKJAVIK
postcode: IS 101

contact info
Titolo: Prof.
Nome: Sigurdur
Cognome: Brynjolfsson
Email: send email
Telefono: +354 525 4641
Fax: +354 525 4632

IS (REYKJAVIK) coordinator 100˙000.00

Mappa

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

metabolic    bacteria    network    aeruginosa    reconstruction    biology    biofilm    model    antibiotics    bacterial    interventions   

 Obiettivo del progetto (Objective)

'Systems biology is a new and rapidly growing discipline. It is widely believed to have a broad transformative potential on both basic and applied studies in the life sciences. In particular, metabolic network reconstructions are playing a key role as they provide a framework for investigation of the mechanism underlying the genotype-phenotype relationship. Pseudomonas aeruginosa is an opportunistic pathogen of clinical relevance with an increasing resistance against available antibiotics, which is partially attributed to its ability to form biofilms. The proposed project will construct a comprehensive biofilm model of P. aeruginosa using a recently published metabolic reconstruction. The biofilm model will represent typical micro-habitats. Hence, it will give insight into distinct metabolic difference of planktonic and biofilm-associated bacteria and may further our understanding as to why biofilm bacteria are resistant to antibiotics. Metabolomic, patient samples will be integrated with the biofilm model which is expected to yield insight into conditions associated with disease progression and manifestation. The biofilm model will also be employed to predict new strategies for therapeutic interventions through in silico gene deletion studies. The project will include the development of relevant reconstruction and analysis methods. This work will set new standards in reconstruction, analysis, and modeling techniques and will build the first large-scale bacterial-community-based network. Gained knowledge will be directly applicable to other single or multi-species bacterial communities. The proposed project will be carried out within the Center for Systems Biology at the University of Iceland. Lastly, the project is well placed within the recent European efforts to apply systems biological approaches towards improving early diagnosis and accelerating the discovery of novel interventions.'

Altri progetti dello stesso programma (FP7-PEOPLE)

BREAST CANCER ORIGIN (2011)

Analysis of the cellular origin of breast cancer

Read More  

HETEROSPIN (2008)

3d-4f-3d trinuclear complexes precursors for heterospin systems - an alternative way towards multifunctional molecular materials

Read More  

ESNSTM (2012)

Electron Spin Noise Scanning Tunneling Microscopy

Read More