E PIAF

Enhanced Protective Immunity Against Filariasis

Coordinatore	THE UNIVERSITY OF EDINBURGH    more  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 651 9023
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	6˙634˙715 €
EC contributo	5˙000˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2009-single-stage
Funding Scheme	CP-FP-SICA
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-03-01   -   2014-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 651 9023	UK (EDINBURGH)	coordinator	1˙449˙784.00
2	THE UNIVERSITY OF LIVERPOOL  Organization address address: Brownlow Hill, Foundation Building 765 city: LIVERPOOL postcode: L69 7ZX contact info Titolo: Ms. Nome: Suzanne Cognome: Halpin Email: send email Telefono: +44 151 7948725 Fax: +44 151 7948728	UK (LIVERPOOL)	participant	610˙912.00
3	UNIVERSITAETSKLINIKUM BONN  Organization address address: Sigmund-Freud-Strasse 25 city: BONN postcode: 53105 contact info Titolo: Ms. Nome: Beate Cognome: Becker Email: send email Telefono: +49 228 287 19454 Fax: +49 228 287 14635	DE (BONN)	participant	559˙670.00
4	MUSEUM NATIONAL D'HISTOIRE NATURELLE  Organization address address: RUE CUVIER 57 city: PARIS postcode: 75005 contact info Titolo: Dr. Nome: Coralie Cognome: Martin Email: send email Telefono: +33 1 40793496 Fax: +33 1 40793499	FR (PARIS)	participant	489˙316.00
5	EBERHARD KARLS UNIVERSITAET TUEBINGEN  Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 contact info Titolo: Prof. Nome: Peter Cognome: Soboslay Email: send email Telefono: +49 7071 2980230 Fax: +49 7071 295996	DE (TUEBINGEN)	participant	478˙516.00
6	Fios Genomics Limited  Organization address address: Buchanan Street 166 city: Glasgow postcode: G1 2LS contact info Titolo: Dr. Nome: Gary Cognome: Rubin Email: send email Telefono: 441315000000 Fax: 441317000000	UK (Glasgow)	participant	400˙000.00
7	Research Foundation in Tropical Diseases and Environment  Organization address address: University Street city: Buea postcode: 474 contact info Titolo: Dr. Nome: Ayuk Peter Cognome: Enyong Email: send email Telefono: +237 77754101 Fax: +237 33323109	CM (Buea)	participant	348˙898.00
8	Kwame Nkrumah University of Science and Technology  Organization address address: "Private Mail Bag, University Post Office" city: Kumasi postcode: Ash contact info Titolo: Mr. Nome: Sabastian Cognome: Kankam Email: send email Telefono: +23 351 60531 Fax: +23 351 62017	GH (Kumasi)	participant	227˙304.00
9	INSTITUT DE RECHERCHE AGRICOLE POUR LE DEVELOPPEMENT  Organization address address: PO BOX city: YAOUNDE postcode: N/A contact info Titolo: Dr. Nome: Vincent Ngwang Cognome: Tanya Email: send email Telefono: +237 7776 9083 Fax: +237 2223 7720	CM (YAOUNDE)	participant	220˙176.00
10	INSTITUT NATIONAL D'HYGIENE  Organization address address: RUE NANGBETO city: LOME postcode: 1396 contact info Titolo: Prof. Nome: Meba Cognome: Banla Email: send email Telefono: +228 550 0954	TG (LOME)	participant	215˙424.00
11	UNIVERSITY OF GLASGOW  Organization address address: University Avenue city: GLASGOW postcode: G12 8QQ contact info Titolo: Mr. Nome: Joe Cognome: Galloway Email: send email Telefono: 441413000000	UK (GLASGOW)	participant	0.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Filarial infections remain a major public health problem in West and Central Africa. Three filarial species are involved: Onchocerca volvulus (onchocerciasis or river blindness); Wuchereria bancrofti (lymphatic filariasis); and Loa loa (the eye worm). Treatment of onchocerciasis with ivermectin has been successful in many situations but emergence of drug resistance and risk of severe adverse reactions associated with L loa co-infections is restricting the implementation of mass treatment and consequently alternate approaches to control are required. Studies with animal models have identified the general mechanisms of protective immunity while human studies have drawn attention to immune regulatory processes that influence clinical presentations Together, these observation provide a basis for vaccine development. The next challenge is to identify target antigens and ensure appropriate formulation and delivery to promote protective responses and avoid any pathology. This project aims to: 1, use transciptomics and bioinformatics to identify the parasite molecules that are targets of protective immunity and that may influence the regulation of such responses; and 2, microarray technologies and bioinformatics to determine the pathways that lead to expression of protective immunity. Cohorts of onchocerciasis patients who have received treatment with ivermectin or tetracycline, or are co infected with either W bancrofti or L loa provide both input to the pathway studies and a means of validation of the computer assimilations. Confirmation of the mechanisms and targets of protective immunity and validation of computer assimilations will also be investigated using the O ochengi-cattle model that also enables experimentation under natural challenge. Litomosoides sigmodontis in mice provides a robust and rapid validation of results obtained from computation relating to expression and regulation of protective responses and a primary system for screening vaccine candidates'

Introduzione (Teaser)

Despite available therapies, parasitic worm infections remain a threat to public health in west and central Africa. EU-funded scientists are working hard to develop new treatments using an innovative approach that considers all the biological systems involved.