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MAGICPAH

Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites

Coordinatore	HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH Organization address address: Inhoffenstrasse 7 city: BRAUNSCHWEIG postcode: 38124 contact info Titolo: Dr. Nome: Michael Cognome: Strätz Email: send email Telefono: +49 531 6181 2020 Fax: +49 531 6181 2299
Nazionalità Coordinatore	Germany [DE]
Totale costo	4˙515˙496 €
EC contributo	2˙997˙137 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2009-3
Funding Scheme	CP-FP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-04-01 - 2014-03-31

Partecipanti

#	participant	country	role	EC contrib. [€]
1	HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH Organization address address: Inhoffenstrasse 7 city: BRAUNSCHWEIG postcode: 38124 contact info Titolo: Dr. Nome: Michael Cognome: Strätz Email: send email Telefono: +49 531 6181 2020 Fax: +49 531 6181 2299	DE (BRAUNSCHWEIG)	coordinator	435˙890.00
2	AARHUS UNIVERSITET Organization address address: Nordre Ringgade 1 city: AARHUS C postcode: 8000 contact info Titolo: Ms. Nome: Britt Sønberg Cognome: Vilstrup Email: send email Telefono: +45 4630 1337 Fax: +45 4630 1114	DK (AARHUS C)	participant	320˙160.00
3	HELMHOLTZ-ZENTRUM FUER UMWELTFORSCHUNG GMBH - UFZ Organization address address: Permoser Strasse 15 city: LEIPZIG postcode: 4318 contact info Titolo: Ms. Nome: Annette Cognome: Schmidt Email: send email Telefono: +49 341 235 1663 Fax: +49 341 235 1386	DE (LEIPZIG)	participant	305˙475.00
4	CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Ms. Nome: Gaetana Cognome: Irrera Email: send email Telefono: +39 090669003 Fax: +39 090669007	IT (ROMA)	participant	303˙534.00
5	BANGOR UNIVERSITY Organization address address: COLLEGE ROAD city: BANGOR postcode: LL57 2DG contact info Titolo: Ms. Nome: Christine Cognome: Davey Email: send email Telefono: +44 1248 382136 Fax: +44 1248 382042	UK (BANGOR)	participant	301˙296.00
6	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Carlos Manuel Cognome: Abad Ruiz Email: send email Telefono: +34 91 566 8852 Fax: +34 91 566 8913	ES (MADRID)	participant	296˙745.00
7	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 contact info Titolo: Mr. Nome: Regis Cognome: Copin Email: send email Telefono: +33 160872506 Fax: +33 160872592	FR (PARIS 15)	participant	284˙505.00
8	DANMARKS TEKNISKE UNIVERSITET Organization address address: Anker Engelundsvej 1, Building 101A city: KONGENS LYNGBY postcode: 2800 contact info Titolo: Ms. Nome: Birte Kastrup Cognome: Rasmussen Email: send email Telefono: +45 45 25 1687 Fax: +45 45 93 2850	DK (KONGENS LYNGBY)	participant	274˙524.00
9	AECOM CZ SRO Organization address address: Trojska 92 city: PRAGUE 7 postcode: 171 00 contact info Titolo: Dr. Nome: Vendulka Cognome: Spiskova Email: send email Telefono: +42 0283090643 Fax: +42 0283090658	CZ (PRAGUE 7)	participant	171˙155.00
10	CORPORACION CORPOGEN Organization address address: CARRERA 5 NO 66A-34 city: BOGOTA postcode: DC contact info Titolo: Mr. Nome: Luis Fernando Cognome: Diaz Email: send email Telefono: +57 1 8050102 Fax: +57 1 3484607	CO (BOGOTA)	participant	139˙086.00
11	UNIVERSITAET LEIPZIG Organization address address: RITTERSTRASSE 26 city: LEIPZIG postcode: 4109 contact info Titolo: Mr. Nome: Gerhard Cognome: Fuchs Email: send email Telefono: +49 341 97 35012 Fax: +49 341 97 35012	DE (LEIPZIG)	participant	89˙871.04
12	SYNDIAL SPA - ATTIVITA DIVERSIFICATE Organization address address: Piazza Boldrini 1 city: SAN DONATO MILANESE postcode: 20097 contact info Titolo: Dr. Nome: Giovanni Cognome: Trovato Email: send email Telefono: +39 2 520 32755	IT (SAN DONATO MILANESE)	participant	50˙005.00
13	ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Organization address address: FAHNENBERGPLATZ city: FREIBURG postcode: 79085 contact info Titolo: Mrs. Nome: Gabriela Cognome: Hafke-Wessel Email: send email Telefono: 497612000000	DE (FREIBURG)	participant	24˙890.96
14	THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO Organization address address: KINGS COLLEGE CIRCLE 27 city: TORONTO postcode: M5S 1A1 contact info Titolo: Dr. Nome: Alexei Cognome: Savchenko Email: send email Telefono: +1 416 978 4013 Fax: +1 416 3404004	CA (TORONTO)	participant	0.00

Mappa

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enzymes catalytic genome bioavailability reactions retrieval genomic marine degradation pahs metabolism meta rational us microbial situ biodegradation pah magicpah bacteria characterization environments screens

Obiettivo del progetto (Objective)

'MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability will be assessed as to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of PAH pollution. We will generate a knowledge base not only on the microbial catabolome for biodegradation of PAHs in various impacted environmental settings based on genome gazing, retrieval and characterization of specific enzymes but also on systems related bioavailability of contaminant mixtures. MAGICPAH takes into account the tremendous undiscovered metagenomic resources by the direct retrieval from genome/metagenome libraries and consequent characterization of enzymes through activity screens. These screens will include a high-end functional small-molecule fluorescence screening platform and will allow us to directly access novel metabolic reactions followed by their rational exploitation for biocatalysis and the re-construction of biodegradation networks. Results from (meta-) genomic approaches will be correlated with microbial in situ activity assessments, specifically dedicated to identifying key players and key reactions involved in anaerobic PAH metabolism. Key processes for PAH metabolism particularly in marine and composting environments and the kinetics of aerobic degradation of PAH under different conditions of bioavailability will be assessed in model systems, the rational manipulation of which will allow us to deduce correlations between system performance and genomic blueprint. The results will be used to improve treatments of PAH-contaminated sites.'

Introduzione (Teaser)

Researchers are mining polluted natural environments for bacteria that can naturally metabolise polyaromatic hydrocarbons (PAHs), a common and toxic pollutant.