PLASMOESCAPE
Monoallelic Gene Expression in Malaria Parasites: A Key Mechanisms in the Pathogen's Survival Strategy
| Coordinatore |
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | Non specificata |
| Totale costo | 1˙815˙480 € |
| EC contributo | 1˙815˙480 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | E |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-06-01 - 2015-05-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | hostInstitution | 1˙815˙480.00 |
| 2 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | hostInstitution | 1˙815˙480.00 |
Mappa
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Obiettivo del progetto (Objective)
'An important number of human and animal pathogens use antigenic variation of surface proteins as a mechanism to avoid destruction by the host s immune system. Most escape mechanisms rely on the successive expression of members of gene families in a mutually exclusive manner, a biological process which remains elusive at the molecular level. The protozoan pathogen Plasmodium falciparum, which infects up to 300 million people causing more than two million lives each year, undergoes antigenic variation to establish chronic blood stage infection. A critical determinant in chronic infection and pathogenesis is the expression of clonally variant molecules at the surface of infected erythrocytes. Several variant gene families undergo antigenic variation in P. falciparum and are expressed during blood stage infection. One family encoded by 60 var genes expresses the most well-known virulence factor causing severe malaria (capillary blockages in the brain and other organs mediated by infected erythrocytes). Switching expression between the 60-member var gene family avoids immune clearance and prolongs the period of infection and transmission to the mosquito. The initial event controlling mono allelic expression at a unique expression site remains elusive and represents the Holly Graal in the field of phenotypic variation. To this end, the major objective of this proposal is to identify specific factors contributing to active expression sites (proteins, DNA enhancer or ncRNA) by using novel strategies such as Proteomics of Isolated Chromatin segments (PICh) and Chromosome Conformation Capture (3C). We expect that new insights into the underlying principles of gene counting of virulence gene families may reveal an Achilles Heel of the parasite s immune evasion strategy.'