RESPARA

Impact of mitochondrial respiration efficiency on plant cell metabolism

Coordinatore	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.    more  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Nicole Cognome: Portee Email: send email Telefono: 493316000000
Nazionalità Coordinatore	Germany [DE]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-RG
Funding Scheme	MC-IRG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-04-01   -   2014-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Nicole Cognome: Portee Email: send email Telefono: 493316000000	DE (MUENCHEN)	coordinator	43˙750.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Mr. Nome: Denis Cognome: Fix Email: send email Telefono: +33 3 88 10 67 19 Fax: +33 3 88 10 86 08	FR (PARIS)	participant	56˙250.00

Mappa

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 Obiettivo del progetto (Objective)

'Respiration plays a key role in the survival of aerobic organisms since it is providing ATP, the energy for the whole cell. The reactions leading to the synthesis of ATP are well known but the mechanisms by which mitochondrial respiration controls cellular functions is unknown, mainly because most mutants in respiratory enzymes are lethal. Two hypotheses have been formulated to explain how respiration activity affects the metabolism. As the product of respiration is ATP, the respiration rate has an impact on the ATP/ADP ratio and on the activity of enzymes using ATP. This control of enzyme activity by the ATP/ADP ratio is known as the adenylate control. Besides, the mitochondrial electron transfer chain (ETC) is producing reactive oxygen species (ROS) when electrons are lost during their transfer through the ETC. As ROS accumulation causes a modification of the redox status and triggers the reorganisation of cellular activity, therefore the influence of ETC activity on cellular metabolism via ROS signalling is another possibility. In plants, most of the mutants with impaired respiration are affected in complex I, the first enzyme of the ETC. These mutants have reduced ATP synthesis and enhanced stress tolerance, indicating that both the adenylate control and the ROS signalling are affected. This project aims to understand how respiration contributes to the control of plant metabolism. Several complex I mutants which possess different levels of remaining complex I activity are available in Arabidopsis. The production of ATP and ROS by the ETC will be investigated to characterise the respiratory defect caused by the reduction in complex I function. System biology approaches including transcriptomic and metabolomic will be use to highlight the mitochondrial signals causing a cellular response and elucidate the corresponding pathways with a special attention to the adenylate control and the ROS signalling pathway.'

Introduzione (Teaser)

Understanding how respiratory activity can modulate cellular metabolism is essential for understanding how our body works. Also, it has implications for the treatment of metabolic disorders.