APOEOSTEOARTHRITIS
"Study of the role of apolipoprotein E (apoE), a key component of the lipid and lipoprotein transport system, in the development of obesity-related osteoarthritis"
| Coordinatore | UNIVERSITY OF PATRAS
Organization address
address: UNIVERSITY CAMPUS RIO PATRAS contact info |
| Nazionalità Coordinatore | Greece [EL] |
| Totale costo | 100˙000 € |
| EC contributo | 100˙000 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2009-RG |
| Funding Scheme | MC-IRG |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-07-01 - 2014-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITY OF PATRAS
Organization address
address: UNIVERSITY CAMPUS RIO PATRAS contact info |
EL (RIO PATRAS) | coordinator | 100˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
'Osteoarthritis (OA) is the most common disease of the joints. However, the molecular mechanisms that are involved in its pathogenesis are still unclear. One of the major causes of OA is obesity. The past few years a lot of studies have focused on the functional link between adipose tissue and cartilage in the development of OA. It has been recently shown that apolipoprotein E (apoE) over-expression promotes diet-induced obesity in mice. In addition, in vitro studies have demonstrated that apoE gene deficiency enhances the reduction of bone in mice fed high-fat diet, while lack of ApoE leads to increased bone formation in mice fed chaw diet. Triggered by these findings, in the present proposal the applicant will use in vivo, biochemical and molecular methodologies in order to investigate the role of ApoE in the pathobiology of obesity-induced OA in mice and explore its implication in the development and progression of OA in humans.'
Introduzione (Teaser)
EU-funded researchers investigated the link between fat regulation and obesity-related degenerative and metabolic bone diseases such as osteoarthritis (OA) and osteoporosis (OP). Experiments have provided novel insight.