META-ARYL

Changing the rules for aromatic substitution reactions: Development of a general meta-selective copper-catalyzed C–H bond functionalization strategy

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Mr. Nome: Keith Cognome: Cann Email: send email Telefono: -334722 Fax: -334167
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	172˙740 €
EC contributo	172˙740 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-05-01   -   2012-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Mr. Nome: Keith Cognome: Cann Email: send email Telefono: -334722 Fax: -334167	UK (CAMBRIDGE)	coordinator	172˙740.80

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 Obiettivo del progetto (Objective)

'This proposal details a new Cu(II) catalysed reactivity concept that will enable the selective C–H bond functionalisation of an important class of aromatic compounds. In particular, a meta-selective C–H arylation of arylacetamides will be the focus of this study. Furthermore, this strategy could also be used to assemble the potent antibiotic, arylomycin A2 as well as facilitate the convenient synthesis of analogues that could be used to probe bacterial resistance, leading to new antibiotic treatments. Our preliminary studies have suggested that this type of transformation is viable for the C–H functionalisation of indoles, acetanilides and anisoles. The capacity to selectively functionalise the C–H bonds of a simple, or complex molecule will be a powerful tool for chemical synthesis and could impact on treatment of diseases.'