BILATERAL MODULATION
Modulating interhemispheric interaction in physiology and disease
| Coordinatore | UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 180˙103 € |
| EC contributo | 180˙103 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2009-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-01-01 - 2013-02-28 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
UK (LONDON) | coordinator | 180˙103.20 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'Homotopic areas of primary motor cortices of both hemispheres are tightly interconnected and show both inhibitory and excitatory interactions, which are delicately balanced in healthy subjects. In disease this balance can be lost or impaired. Accordingly, some movement disorders occur lateralised. In early Parkinson’s Disease (PD) symptoms begin unilaterally, although unilateral changes on the cortical level are lacking. In focal task-induced hand dystonia (FHD) symptoms solely occur on one side and only spread in a minority of patients also to the other side. However, the pathophysiological role of interhemispheric interaction between both primary motor cortices in PD and FHD and its influence on cerebro-muscular coupling and cerebral oscillatory networks subserving motor activity is not finally understood yet. Repetitive transcranial magnetic stimulation (rTMS) allows to modulate human brain activity. Using this feature it becomes possible to explore the characteristics of physiological and pathological cerebral networks and to modify these temporarily. Magnetoencephalography (MEG) enables us to characterise oscillatory synchronisation in the human brain. Moreover, MEG offers the possibility to scrutinise cerebro-muscular and cerebro-cerebral couplings. This allows to describe broad cerebral oscillatory networks including interhemispheric coupling. Combining rTMS and MEG the proposed project aims to reveal, how rTMS acts on the interhemispheric interaction in patients suffering from both PD and FHD and healthy subjects. Moreover, changes of oscillatory synchronisation induced by rTMS, i.e. resting state brain activity, cerebral oscillatory networks and cerebro-muscular coupling, will be characterised. Hence, results have the potential to enhance our understanding of the role of interhemispheric interaction in physiology and disease and to characterise the impact of disturbance of this interaction in PD and FHD.'