BRAIN IRON IN ADHD

BRAIN IRON LEVELS IN CHILDREN WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER: AN IMAGING AND NEUROPHYSIOLOGICAL STUDY

Coordinatore	UNIVERSITA DEGLI STUDI DI VERONA    more  Organization address address: VIA DELL ARTIGLIERE 8 city: VERONA postcode: 37129 contact info Titolo: Dr. Nome: Elisabetta Cognome: Guidi Email: send email Telefono: +39 0 458027208 Fax: +39 0 458027180
Nazionalità Coordinatore	Italy [IT]
Totale costo	239˙604 €
EC contributo	239˙604 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IOF
Funding Scheme	MC-IOF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-09-01   -   2013-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI VERONA  Organization address address: VIA DELL ARTIGLIERE 8 city: VERONA postcode: 37129 contact info Titolo: Dr. Nome: Elisabetta Cognome: Guidi Email: send email Telefono: +39 0 458027208 Fax: +39 0 458027180	IT (VERONA)	coordinator	239˙604.70

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 Obiettivo del progetto (Objective)

'The applicant is a child psychiatrist whose overall research objective is to understand the etiopathophysiology of common childhood mental disorders in order to identify more effective treatment and preventive strategies. The proposal is designed to provide the applicant with advanced interdisciplinary skills in brain imaging and neurophysiology. This will be necessary for the success of the proposed research as well as of future innovative projects, supporting the transition from mentored to independent researcher. The project aims to gain insight into the etiopathophysiology of Attention-Deficit/Hyperactivity Disorder (ADHD), one of the most common and impairing childhood mental disorders. Current ADHD treatment is symptomatic, not curative. Treatments targeting etiopathophysiological mechanisms may provide specific curative action. Preliminary data by the applicant’s group suggest that iron deficiency (ID) is a possible etiopathophysiological candidate in ADHD. The proposed research aims to extend these results comparing brain iron levels, estimated by a novel imaging approach (magnetic field correlation), in 20 children with ADHD and 20 healthy controls, and correlating them with measures of functional connectivity. Moreover, the unexplored correlation between brain iron and parameters from electroencephalogram, polysomnogram, and event-related potentials will be assessed in an additional sample of 20 children with ADHD. The project includes specific training in “Translational Developmental Neuroscience,” with a focus on brain imaging, at the Institute for Pediatric Neuroscience, New York University, NY, and training in neurophysiology at the Child Neuropsychiatry Unit, Verona University, Italy. The expected results have the potential to confirm the role of ID in ADHD, providing a strong rationale for large trials of iron supplementation. Considering the low cost of iron therapy and the high prevalence of ADHD, the proposal exhibits high public health relevance'

Introduzione (Teaser)

Brain iron levels in ADHD patients