TIMCAT

Novel catalytic function in a TIM-barrel scaffold

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Mr. Nome: Keith Cognome: Cann Email: send email Telefono: +44 1223 333 543 Fax: +44 1223 332 988
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	174˙240 €
EC contributo	174˙240 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IIF
Funding Scheme	MC-IIF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-06-01   -   2012-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Mr. Nome: Keith Cognome: Cann Email: send email Telefono: +44 1223 333 543 Fax: +44 1223 332 988	UK (CAMBRIDGE)	coordinator	174˙240.80

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 Obiettivo del progetto (Objective)

'The TIM-barrel fold is the most widely found in nature, making up about 6% of the structures in the Protein Data Bank, and has been found in nature to catalyse reactions from five of the six EC classes. These facts all indicate the extraordinary capacity of the TIM-barrel as a reaction container, and suggest that it may be a versatile starting scaffold into which new catalytic capability can be engineered. In this research programme we will use directed evolution approaches, including state-of-the-art gene shuffling techniques developed in the Hollfelder lab at the University of Cambridge to tengineer novel catalytic function into a TIM-barrel scaffold.'