SEQ-MCR

New Sequential Multicomponent Reactions

Coordinatore	UNIVERSITE BORDEAUX I    more  Organization address address: 351 Cours de la Liberation city: TALENCE postcode: 33405 contact info Titolo: Prof. Nome: Yannick Cognome: Landais Email: send email Telefono: -40002261 Fax: -40006324
Nazionalità Coordinatore	France [FR]
Totale costo	166˙645 €
EC contributo	166˙645 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IIF
Funding Scheme	MC-IIF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-10-01   -   2012-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE BORDEAUX I  Organization address address: 351 Cours de la Liberation city: TALENCE postcode: 33405 contact info Titolo: Prof. Nome: Yannick Cognome: Landais Email: send email Telefono: -40002261 Fax: -40006324	FR (TALENCE)	coordinator	166˙645.60

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 Obiettivo del progetto (Objective)

'Multicomponent reactions (MCR) have recently attracted a great deal of attention as they are considered as a kind of “holy grail” for organic chemists. Although new examples are constantly flourishing in the literature, there are a limited number of processes that allow multiple components to react together in a single operation. We propose to develop new processes involving two consecutive multicomponent reactions that would open a rapid access to biologically relevant 6-membered ring lactones and lactams. The carbon backbone will be generated using a three-component radical cascade between a xanthate, an olefin and a sulfinyl oxime, followed by the hydrolysis of the resident oxime into an aldehyde, which will be one of the partners in the subsequent multicomponent reaction. 3, 4 and 5CR-radical-, /Aldol, /Mannich and /Petasis reactions will thus be studied that should provide a large variety of lactams and lactones in a diastereocontrolled manner. An application of this strategy to the synthesis of relevant alkaloids is also proposed that should illustrate the power of sequential multicomponent reactions in organic synthesis. This conceptually novel approach should lead to valuable intermediates for organic synthesis, with high bond forming efficiency. The project is based on atom and step economy concepts, two of the most important principles of “green and sustainable chemistry”. Although yet at a fundamental level, this research has potent applications in new technologies, including synthesis automation, which is of high industrial interest. This project is also aimed at training a promising organic chemist from an emerging country, in sustainable chemistry, a fundamental objective in chemical sciences. The researcher that should develop this project has been educated in one of the best chemical institute in India, and possesses an excellent scientific background with seven years experience in total synthesis, having led to remarkable achievements.'