ENDOFOOD

Neurocircuitry of endocannabinoid regulation of food intake

Coordinatore	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	France [FR]
Totale costo	1˙500˙000 €
EC contributo	1˙500˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-StG_20091118
Funding Scheme	ERC-SG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-02-01   -   2016-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Dr. Nome: Giovanni Cognome: Marsicano Email: send email Telefono: +33 5 57573756 Fax: +33 5 57573642	FR (PARIS)	hostInstitution	1˙500˙000.00
2	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Mr. Nome: Philippe Cognome: Leconte Email: send email Telefono: +33 5 57573600 Fax: +33 5 57573655	FR (PARIS)	hostInstitution	1˙500˙000.00

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 Obiettivo del progetto (Objective)

'Few tasks executed by the brain hold greater survival and adaptive value than keeping us fed and in adequate nutritional state. The regulation of energy metabolism represents a prototypical homeostatic system, with the brain acting as the central coordinator. Any alteration of these mechanisms can lead to pathological states threatening the survival of the individual. The main brain region regulating food intake behaviour is the hypothalamus. The endocannabinoid system (ECS), formed by cannabinoid receptors, their endogenous ligands (endocannabinoids) and the enzymatic machinery for the synthesis and degradation of endocannabinoids is centrally involved in the regulation of food intake. This project aims at defining the mechanisms of the ECS-mediated control of food intake. We will reach the following goals:

1.We will generate advanced genetic tools allowing conditional deletion, rescue and overexpression of ECS elements. The integrated use of these tools will lead to the detailed mapping of the brain neurocircuitries where the ECS controls food intake. 2.We will provide strong evidence pointing to differential functions of the ECS in food intake, depending on the specific circuits activated. 3.We will determine which endocannabinoid(s) are involved in specific aspects of food intake. 4.We will detail the electrophysiological impact of the ECS on the hypothalamic neuronal network regulating food intake. 5.We will identify novel biochemical mechanisms, linking the ECS to hypothalamic neuronal activity, mitochondrial functions and regulation of food intake. This project has the ambitious aim to explore new scientific avenues and to provide “in depth” knowledge on the neuronal mechanisms regulating ingestive behaviour in mammals. The results of this project will pave the way to novel lines of research for the physiology and pharmacology of the ECS in the control of energy balance.'