BRAINSTATES

"Brain states, synapses and behaviour"

Coordinatore	MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙463˙125 €
EC contributo	1˙463˙125 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-StG_20091118
Funding Scheme	ERC-SG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-02-01   -   2016-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT  Organization address address: ROBERT ROSSLE STRASSE 10 city: BERLIN postcode: 13125 contact info Titolo: Dr. Nome: Ioannis Cognome: Legouras Email: send email Telefono: +49 30 94064247 Fax: +49 30 94062700	DE (BERLIN)	hostInstitution	1˙463˙125.00
2	MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT  Organization address address: ROBERT ROSSLE STRASSE 10 city: BERLIN postcode: 13125 contact info Titolo: Dr. Nome: James Cognome: Poulet Email: send email Telefono: +49 30 450 528077	DE (BERLIN)	hostInstitution	1˙463˙125.00

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 Obiettivo del progetto (Objective)

'Global changes in patterns of neuronal activity or brain state are the first phenomenon recorded in the awake human brain (1). Changes in brain state are present in recordings of neocortical activity from mouse to man. It is now thought that changes in brain state are fundamental to normal brain function and neuronal computation. Despite their importance, we have very little idea about the underlying neuronal mechanisms that generate them or their precise impact on neuronal processing and behaviour. In previous work we have characterised brain state changes in a well characterised model for neuroscience research the mouse whisker system. We have recorded changes in the brain state in mouse cortex during whisker movements (2). In this proposal, we aim to use the mouse whisker system further to investigate the mechanisms and functions of changes in brain state. First we will use state of the art techniques to record and manipulate neuronal activity in the awake, behaving mouse to investigate the network and cellular mechanisms involved in generating brain state. Second we will use 2-photon microscopy to investigate the impact of brain state on excitatory and inhibitory synaptic integration in vivo. Finally we will use behaviourally trained mice to measure the impact of brain state changes on sensory perception and behaviour. This proposal will therefore provide fundamental insights into brain function at every step: mechanisms of changes in brain state, how neurons communicate with eachother and how the brain controls sensory perception and behaviour. References 1 Berger H (1929) Archiv für Psychiatrie und Nervenkrankheiten 87:527-570. 2 Poulet JFA, Petersen CC (2008) Nature 454:881-885.'