MORPHO-SIGNALING

Quantitative analysis of the interplay between cellular signaling and cell morphology during development

Coordinatore	TEL AVIV UNIVERSITY    more  Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 contact info Titolo: Ms. Nome: Lea Cognome: Pais Email: send email Telefono: 97236408774 Fax: 97236409697
Nazionalità Coordinatore	Israel [IL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-RG
Funding Scheme	MC-IRG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-03-01   -   2015-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TEL AVIV UNIVERSITY  Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 contact info Titolo: Ms. Nome: Lea Cognome: Pais Email: send email Telefono: 97236408774 Fax: 97236409697	IL (TEL AVIV)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'During development, cells differentiate into well defined patterns through an orchestrated program in space and time. This differentiation into different cell states is coordinated by intercellular signaling and is interpreted via intracellular genetic circuits. However, many developmental processes also involve changes in cell morphology that occur concurrently with the differentiation process. How such morphological changes affect intercellular signaling? How cell morphology changes are controlled by intercellular signaling? And how the dynamic interplay between intercellular signaling, intracellular genetic circuits and regulation of cellular morphology generate the observed differentiation patterns? We will address these questions in the context of the Notch signaling pathway and Notch dependent pattern formation processes. Using a combination of micropatterning devices and quantitative time lapse microscopy, we will first measure the dependence of Notch signaling on the properties of the boundary between pairs of cells (e.g. length of boundary, molecular and mechanical properties). We will then use the information obtained from these measurements to construct mathematical models of Notch dependent pattern formation processes combining cell-cell signaling, intracellular circuitry and cell morphology in a unified manner. Such a combined experimental and theoretical approach will not only provide new insights into the Notch signaling pathway but will also provide a new framework for a whole class of developmental patterning processes involving morphological changes during differentiation.'

Introduzione (Teaser)

During development, various signalling pathways are activated or silenced directing cell differentiation in space and time. An EU-funded study is investigating the relationship between signalling and cell morphology in determining cell fate decisions.