FI2P4TUM
Fluorescence intraoperative imaging platform for tumor margin delineation
| Coordinatore | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 162˙742 € |
| EC contributo | 162˙742 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2010-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-07-01 - 2013-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
DE (MUENCHEN) | coordinator | 162˙742.40 |
Mappa
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Obiettivo del progetto (Objective)
'According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. Among the distinct types of cancer treatments, surgery, which is the oldest modality, is still often confronted with difficulties in the identification of cancer spread and the accurate delineation of tumor margins. This is of uttermost importance in order to infer the lowest harm to the organ where the tumor originated but without leaving residual tumor. This proposal is intended to improve the surgical outcome, employing a highly sensitive fluorescence imaging approach, which holds a strong potential to become a key technology in intraoperative imaging. The primary goal is to employ realâ€time multiâ€spectral fluorescence imaging for sensitive and quantitative molecular visualization of infiltrating cancer, which can enable realâ€time surgical feedback and improved surgical outcome over the current state of the art and clinical practice. For this goal an advanced multiâ€spectral fluorescence imaging system that can significantly improve quantification and the observation accuracy over simple fluorescence video systems considered in the past, will be developed. Further promising new fluorescence probes will be utilized and their ability to offer high detection sensitivity and specificity of tumor margins will be investigated. The performance of this approach will be examined in controlled phantoms and inâ€vivo in breast cancer and abdominal cancer in animal models. Moreover, the method will be examined in relation to offering realâ€time pathology of lymphâ€nodes inâ€vivo. If this proposal is successful, it will lead to the development of an accurate imaging platform that can enhance surgical vision while seamlessly integrating in the operating surgical room. Due to the direct relation of the surgeon’s vision to optical methods and the relatively low cost and nonâ€ionizing energies used, a high dissemination potential into the surgical healthcare is expected.'
Introduzione (Teaser)
Imaging technologies have become standard for cancer tumour detection, staging and treatment evaluation. However, bringing them to operation and endoscopy suites for the accurate estimation of tumour and lesion margins remains a challenge.