REVERSIBLE COGNITION

Prefrontal and cingulate interactions in cognitive control: reversible inactivation and electrocorticograms

Coordinatore	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)    more  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Mr. Nome: Dominique Cognome: Pella Email: send email Telefono: +33 4 72 13 88 00 Fax: +33 4 72 13 88 01
Nazionalità Coordinatore	France [FR]
Totale costo	185˙748 €
EC contributo	185˙748 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-01   -   2014-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Mr. Nome: Dominique Cognome: Pella Email: send email Telefono: +33 4 72 13 88 00 Fax: +33 4 72 13 88 01	FR (PARIS)	coordinator	185˙748.00

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 Obiettivo del progetto (Objective)

'An important feature of human cognition is its remarkable flexibility. Cognitive control refers to processes that allow behaviour to vary adaptively depending on current goals. Understanding it is therefore fundamental to knowing how our behaviour can be adapted and flexible. Deficits in cognitive control, and imbalances in related neurotransmitters such as dopamine, are associated with a number of psychological and neurological conditions, including schizophrenia and the cognitive symptoms of Parkinson’s disease. Both prefrontal cortex (PFC) and anterior cingulate cortex (ACC) are known to have important roles in cognitive control, but the details of how they achieve this, how they interact, and the roles of those neurotransmitters are unclear. An important way to discover this is to record the effects of inactivating those regions and neurotransmitter systems, as this reveals how these systems are critical to cognition.

This project will reveal the nature of the frontal lobe interactions that subserve cognitive control, and their neurochemical basis, by combining inactivation and neurophysiological techniques.

In macaque monkeys performing a well-established test of multiple elements of cognitive control, we will reversibly inactivate targeted regions of ACC and PFC whilst simultaneously recording continuous neurophysiological data using chronically implanted electroencephalography. We will go on to record the same data during reversible localized blockade of targeted neurotransmitter systems, beginning with dopamine, and then to functionally disconnect ACC and PFC.

The project will have significant benefits for both fundamental and clinical research, and represents a rare combination of techniques made possible by mobility between laboratories. It will substantially enhance the career of the researcher.'

Introduzione (Teaser)

Primates have a wide range of cognitive abilities. An EU project conducted extensive research with macaque monkeys to find out how advanced primates learn.