ARIMMORA

Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment

Coordinatore	Foundation for Research on Information Technologies in Society    more  Organization address address: Zeughausstrasse 43 city: Zurich postcode: 8004 contact info Titolo: Dr. Nome: Iris Cognome: Szankowski Email: send email Telefono: 41442459686 Fax: 41442459699
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	4˙577˙320 €
EC contributo	3˙249˙970 €
Programma	FP7-ENVIRONMENT Specific Programme "Cooperation": Environment (including Climate Change)
Code Call	FP7-ENV-2011
Funding Scheme	CP-FP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-01   -   2015-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	Foundation for Research on Information Technologies in Society  Organization address address: Zeughausstrasse 43 city: Zurich postcode: 8004 contact info Titolo: Dr. Nome: Iris Cognome: Szankowski Email: send email Telefono: 41442459686 Fax: 41442459699	CH (Zurich)	coordinator	231˙958.00
2	UNIVERSITAET BASEL  Organization address address: Petersplatz 1 city: BASEL postcode: 4003 contact info Titolo: Prof. Nome: Primo Cognome: Schär Email: send email Telefono: +41 61 2670767 Fax: +41 61 2673566	CH (BASEL)	participant	725˙244.80
3	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Eusebio Cognome: Jiménez Arroyo Email: send email Telefono: +34 91 566 8852 Fax: +34 91 566 89 13	ES (MADRID)	participant	666˙529.50
4	Schmid & Partner Engineering AG  Organization address address: Zeughausstrasse 43 city: Zurich postcode: 8004 contact info Titolo: Dr. Nome: Katja Cognome: Pokovic Email: send email Telefono: 41442459707 Fax: 41442459779	CH (Zurich)	participant	490˙489.20
5	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V  Organization address address: Hansastrasse 27C city: MUENCHEN postcode: 80686 contact info Titolo: Ms. Nome: Andrea Cognome: Zeumann Email: send email Telefono: +49 89 1205 2723 Fax: +49 89 1205 7534	DE (MUENCHEN)	participant	433˙245.00
6	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Talia Cognome: Tzahor Email: send email Telefono: +972 8 934 4026 Fax: +972 8934 4165	IL (REHOVOT)	participant	277˙049.60
7	CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER  Organization address address: Cours Albert-Thomas 150 city: LYON CEDEX 08 postcode: 69372 contact info Titolo: Dr. Nome: Olaf Cognome: Kelm Email: send email Telefono: +33 4 727 384 94 Fax: +33 4 727 385 75	FR (LYON CEDEX 08)	participant	173˙766.00
8	STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER  Organization address address: BUNTEWEG 2 city: HANNOVER postcode: 30559 contact info Titolo: Mr. Nome: Peter Cognome: Joppe Email: send email Telefono: +49 511 953 8020 Fax: +49 511 953 828020	DE (HANNOVER)	participant	156˙153.60
9	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Paolo Cognome: Ravazzani Email: send email Telefono: +39 02 23993344 Fax: +39 02 23993367	IT (ROMA)	participant	95˙535.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Based on epidemiological evidence supporting an ssociation between residential exposure to extremely low frequency magnetic fields (ELF MF) and childhood leukaemia, ELF MF have been classified as possibly carcinogenic to humans. The proposed project aims to scrutinize the underlying biophysical mechanisms and to clarify a possible causal relationship between ELF MF exposure and cancer, especially childhood leukaemia. This will be achieved by 1) developing and applying novel experimental and computational techniques to close knowledge gaps in the exposure assessment to ELF MF and 2) applying advanced biological in vitro, ex vivo and in vivo models and techniques under well-defined exposure conditions to test likely interaction mechanisms. The selected experimental approach is based on epidemiological evidence and current knowledge about the molecular processes underlying acute leukaemia in children. It aims to investigate the possible impact of ELF-MF exposure: 1) on the epigenetic dynamics associated with hematopoietic cell lineage commitment and differentiation; epigenetic signatures will be monitored genome-wide, and mechanisms underlying eventual “misprogramming” will be addressed in gene promoter models; 2) on the alteration of signalling processes in cells; 3) on the induction of possible cytotoxic effects on CD8 positive T cells; and 4) on the genesis or evolution of childhood leukaemia by generating genetically modified advanced animal models. Advanced biophysical simulations with efficient numerical solvers combined with the latest tissue and cellular models will be implemented to support the bioexperiments. A risk assessment will be performed at the end based on studies conducted within the project and correlated to recent studies conducted outside the consortium by adapting and applying procedures as outlined by the International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Risks to Humans.'

Introduzione (Teaser)

The link between extremely-low-frequency magnetic fields (ELF-MFs) and cancer is still unproven. An EU-funded project is working to assess the risks of childhood leukaemia in association with exposure to ELF-MFs.