ARIMMORA
Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment
| Coordinatore | Foundation for Research on Information Technologies in Society
Organization address
address: Zeughausstrasse 43 contact info |
| Nazionalità Coordinatore | Switzerland [CH] |
| Totale costo | 4˙577˙320 € |
| EC contributo | 3˙249˙970 € |
| Programma | FP7-ENVIRONMENT
Specific Programme "Cooperation": Environment (including Climate Change) |
| Code Call | FP7-ENV-2011 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-10-01 - 2015-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
Foundation for Research on Information Technologies in Society
Organization address
address: Zeughausstrasse 43 contact info |
CH (Zurich) | coordinator | 231˙958.00 |
| 2 |
UNIVERSITAET BASEL
Organization address
address: Petersplatz 1 contact info |
CH (BASEL) | participant | 725˙244.80 |
| 3 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 666˙529.50 |
| 4 |
Schmid & Partner Engineering AG
Organization address
address: Zeughausstrasse 43 contact info |
CH (Zurich) | participant | 490˙489.20 |
| 5 |
FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V
Organization address
address: Hansastrasse 27C contact info |
DE (MUENCHEN) | participant | 433˙245.00 |
| 6 |
WEIZMANN INSTITUTE OF SCIENCE
Organization address
address: HERZL STREET 234 contact info |
IL (REHOVOT) | participant | 277˙049.60 |
| 7 |
CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
Organization address
address: Cours Albert-Thomas 150 contact info |
FR (LYON CEDEX 08) | participant | 173˙766.00 |
| 8 |
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Organization address
address: BUNTEWEG 2 contact info |
DE (HANNOVER) | participant | 156˙153.60 |
| 9 |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address
address: Piazzale Aldo Moro 7 contact info |
IT (ROMA) | participant | 95˙535.00 |
Mappa
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Obiettivo del progetto (Objective)
'Based on epidemiological evidence supporting an ssociation between residential exposure to extremely low frequency magnetic fields (ELF MF) and childhood leukaemia, ELF MF have been classified as possibly carcinogenic to humans. The proposed project aims to scrutinize the underlying biophysical mechanisms and to clarify a possible causal relationship between ELF MF exposure and cancer, especially childhood leukaemia. This will be achieved by 1) developing and applying novel experimental and computational techniques to close knowledge gaps in the exposure assessment to ELF MF and 2) applying advanced biological in vitro, ex vivo and in vivo models and techniques under well-defined exposure conditions to test likely interaction mechanisms. The selected experimental approach is based on epidemiological evidence and current knowledge about the molecular processes underlying acute leukaemia in children. It aims to investigate the possible impact of ELF-MF exposure: 1) on the epigenetic dynamics associated with hematopoietic cell lineage commitment and differentiation; epigenetic signatures will be monitored genome-wide, and mechanisms underlying eventual “misprogramming” will be addressed in gene promoter models; 2) on the alteration of signalling processes in cells; 3) on the induction of possible cytotoxic effects on CD8 positive T cells; and 4) on the genesis or evolution of childhood leukaemia by generating genetically modified advanced animal models. Advanced biophysical simulations with efficient numerical solvers combined with the latest tissue and cellular models will be implemented to support the bioexperiments. A risk assessment will be performed at the end based on studies conducted within the project and correlated to recent studies conducted outside the consortium by adapting and applying procedures as outlined by the International Agency for Research on Cancer (IARC) Monographs on the Evaluation of Carcinogenic Risks to Humans.'
Introduzione (Teaser)
The link between extremely-low-frequency magnetic fields (ELF-MFs) and cancer is still unproven. An EU-funded project is working to assess the risks of childhood leukaemia in association with exposure to ELF-MFs.