FLATOUT
From Flat to Chiral: A unified approach to converting achiral aromatic compounds to optically active valuable building blocks
| Coordinatore | UNIVERSITAT WIEN
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | Austria [AT] |
| Totale costo | 1˙487˙000 € |
| EC contributo | 1˙487˙000 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2011-StG_20101014 |
| Funding Scheme | ERC-SG |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-01-01 - 2016-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Organization address
address: KAISER WILHELM PLATZ 1 contact info |
DE (MUELHEIM AN DER RUHR) | beneficiary | 252˙000.00 |
| 2 |
UNIVERSITAT WIEN
Organization address
address: UNIVERSITATSRING 1 contact info |
AT (WIEN) | hostInstitution | 1˙235˙000.00 |
| 3 |
UNIVERSITAT WIEN
Organization address
address: UNIVERSITATSRING 1 contact info |
AT (WIEN) | hostInstitution | 1˙235˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
'The stereoselective preparation of enantioenriched organic compounds of high structural complexity and synthetic value, in an economically viable and expeditious manner, is one of the most important goals in contemporary Organic Synthesis. In this proposal, I present a unified and conceptually novel approach for the conversion of flat, aromatic heterocycles into highly valuable compounds for a variety of applications. This approach hinges upon a synergistic combination of the dramatic power of organic photochemical transformations combined with the exceedingly high selectivity and atom-economy of efficient catalytic processes. Indeed, the use of probably the cheapest reagent (light) combined with a catalytic transformation ensures near perfect atom-economy in this journey from flat and inexpensive substructures to chiral added-value products. Conceptually, the photochemical operation is envisaged as a energy-loading step whereas the catalytic transformation functions as an energy-release where asymmetric information is inscribed into the products. The chemistry proposed herein will open up new vistas in enantioselective synthesis. Furthermore, groundbreaking and unprecedented methodology in the field of catalytic allylic alkylation is proposed that significantly expands (and goes beyond) the currently accepted “dogmas” for these textbook reactions. These include (but are not limited to) systematic violations of well-established rules “by design”, new contexts for application, new activation modes and innovative leaving groups. Finally, the comprehensive body of synthetic technology presented will be applied to pressing target-oriented problems in Organic Synthesis. It shall result in a landmark, highly efficient total synthesis of Tamiflu, as well as in application to an environmentally important target (Fomannosin), allowing the easy production of analogues for biological testing.'