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BIOCASCADES SIGNED

BIOCASCADES- Sustainable and Scalable Biocatalytic Cascade Reactions Training Network

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BIOCASCADES project word cloud

Explore the words cloud of the BIOCASCADES project. It provides you a very rough idea of what is the project "BIOCASCADES" about.

minimize biotechnology explore qualified pot enterprises international versatile ideas enzymatic combines create workshops graduates form energy rely purification academia chemo young sized secondments industry move interdisciplinary joint benign doctorate reaction creates alone environment nine intermediate tailor protein waste drivers skills engineering ventures environmentally biocascades outsourcing made dynamic companies isolated downstream philosophy esrs chemistry scientific reactions networks green efficient biocatalysis stage sustainable medium expertise stand contribution demand combining careers smes small academic training compartmentalization avoiding formed laboratories biotech entrepreneurship network commercially cascade innovative transferable collaborative techniques more

Project "BIOCASCADES" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITAET GRAZ Organization address address: RECHBAUERSTRASSE 12 city: GRAZ postcode: 8010 website: www.tugraz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Project website	http://www.biocascades.eu/
Total cost	2˙787˙956 €
EC max contribution	2˙787˙956 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-EID
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET GRAZ TECHNISCHE UNIVERSITAET GRAZ Organization address address: RECHBAUERSTRASSE 12 city: GRAZ postcode: 8010 website: www.tugraz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	coordinator	255˙934.00
2	KUNGLIGA TEKNISKA HOEGSKOLAN KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	263˙659.00
3	SAROMICS BIOSTRUCTURES AB SAROMICS BIOSTRUCTURES AB Organization address address: MEDICON VILLAGE city: Lund postcode: 223 81 website: www.saromics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (Lund)	participant	263˙659.00
4	VIAZYM BV VIAZYM BV Organization address address: MOLENGRAAFFSINGEL 10 city: DELFT postcode: 2629 JD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	255˙374.00
5	ENZYMICALS AG ENZYMICALS AG Organization address address: WALTHER-RATHENAU-STRASSE 49A city: GREIFSWALD postcode: 17489 website: www.enzymicals.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GREIFSWALD)	participant	249˙216.00
6	RUHR-UNIVERSITAET BOCHUM RUHR-UNIVERSITAET BOCHUM Organization address address: UNIVERSITAETSSTRASSE 150 city: BOCHUM postcode: 44801 website: www.rub.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BOCHUM)	participant	249˙216.00
7	TECHNISCHE UNIVERSITAET BRAUNSCHWEIG TECHNISCHE UNIVERSITAET BRAUNSCHWEIG Organization address address: UNIVERSITAETSPLATZ 2 city: BRAUNSCHWEIG postcode: 38106 website: www.tu-braunschweig.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	participant	249˙216.00
8	UNIVERSITAET BIELEFELD UNIVERSITAET BIELEFELD Organization address address: UNIVERSITAETSSTRASSE 25 city: BIELEFELD postcode: 33615 website: www.uni-bielefeld.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BIELEFELD)	participant	249˙216.00
9	UNIVERSITAET GREIFSWALD UNIVERSITAET GREIFSWALD Organization address address: DOMSTRASSE 11 city: GREIFSWALD postcode: 17489 website: www.uni-greifswald.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GREIFSWALD)	participant	249˙216.00
10	DSM CHEMICAL TECHNOLOGY R & D BV DSM CHEMICAL TECHNOLOGY R & D BV Organization address address: POSTSTRAAT 1 city: SITTARD postcode: 6135 KR website: www.dsm.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (SITTARD)	participant	134˙780.00
11	ENTRECHEM SL ENTRECHEM SL Organization address address: EDIFICIO CIENTIFICO TECNOLOGICO CAMPUS EL CRISTO city: OVIEDO postcode: 33006 website: www.entrechem.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (OVIEDO)	participant	123˙936.00
12	UNIVERSIDAD DE OVIEDO UNIVERSIDAD DE OVIEDO Organization address address: CALLE SAN FRANCISCO 3 city: OVIEDO postcode: 33003 website: www.uniovi.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (OVIEDO)	participant	123˙936.00
13	INNOSYN BV INNOSYN BV Organization address address: URMONDERBAAN 22 city: GELEEN postcode: 6167 RD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GELEEN)	participant	120˙593.00
14	TECHNISCHE UNIVERSITEIT DELFT TECHNISCHE UNIVERSITEIT DELFT Organization address address: STEVINWEG 1 city: DELFT postcode: 2628 CN website: www.tudelft.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	partner	0.00

Map

Project objective

In BIOCASCADES, nine early-stage researchers (ESRs) will investigate the development of sustainable (chemo)enzymatic cascade reactions under the ‘green chemistry’ philosophy. The proposed BIOCASCADES project combines different techniques such as compartmentalization, protein engineering and reaction engineering in order to develop commercially viable and environmentally benign one pot reactions. By avoiding intermediate downstream- and purification-steps, cascade reactions minimize production costs, energy demand and waste production and are thus expected to make a major contribution for the development of sustainable and efficient production processes.

Small- and medium sized enterprises (SMEs) are emerging as main drivers of European Research. They are dynamic, explore new areas and create new ideas, while large companies rely more and more on outsourcing research or involving SMEs by joint ventures. However, small companies are not strong enough as stand-alone enterprises, which requires them to form networks with other SMEs and academia. This creates a strong demand for young researchers who can move freely in an international and interdisciplinary environment. In a tailor-made training program BIOCASCADES aims to provide the nine early stage researchers with specific scientific and transferable skills for careers in the highly dynamic European biotechnology sector. Training at leading laboratories of biocatalysis will develop their scientific skills, while secondments to the industry and specific workshops will develop their entrepreneurship. The graduates of this doctorate program will be highly qualified for collaborative research between European academia and industry.

The consortium is formed by leading academic laboratories from biocatalysis and protein engineering together with a network of four innovative biotech companies. By combining their versatile expertise, the consortium can achieve a success that would not be possible in isolated projects.

Deliverables

List of deliverables.
Summer school & training events	Documents, reports	2019-07-22 14:33:07
Dissemination and public engagement report	Documents, reports	2019-07-22 14:33:07
Website	Websites, patent fillings, videos etc.	2019-07-22 14:33:07
Committees	Documents, reports	2019-07-22 14:33:07

Take a look to the deliverables list in detail: detailed list of BIOCASCADES deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Sandy Schmidt, Harald GrÃ¶ger, Robert Kourist Durch Trennen verbinden published pages: 985-988, ISSN: 1439-9598, DOI: 10.1002/nadc.20174058532	Nachrichten aus der Chemie 65/10	2019-07-22
2017	Elisa Liardo, NicolÃ¡s RÃos-LombardÃa, Francisco MorÃs, Francisca Rebolledo, Javier GonzÃ¡lez-SabÃn Hybrid Organo- and Biocatalytic Process for the Asymmetric Transformation of Alcohols into Amines in Aqueous Medium published pages: 4768-4774, ISSN: 2155-5435, DOI: 10.1021/acscatal.7b01543	ACS Catalysis 7/7	2019-07-22
2019	Aline Telzerow, Juraj Paris, Maria HÃ¥kansson, Javier GonzÃ¡lez-SabÃn, NicolÃ¡s RÃos-LombardÃa, Martin SchÃ¼rmann, Harald GrÃ¶ger, Francisco MorÃs, Robert Kourist, Helmut Schwab, Kerstin Steiner Amine Transaminase from Exophiala Xenobiotica â€”Crystal Structure and Engineering of a Fold IV Transaminase that Naturally Converts Biaryl Ketones published pages: 1140-1148, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b04524	ACS Catalysis 9/2	2019-07-22
2019	Juraj Paris, Aline Telzerow, NicolÃ¡s RÃos-LombardÃa, Kerstin Steiner, Helmut Schwab, Francisco MorÃs, Harald GrÃ¶ger, Javier GonzÃ¡lez-SabÃn Enantioselective One-Pot Synthesis of Biaryl-Substituted Amines by Combining Palladium and Enzyme Catalysis in Deep Eutectic Solvents published pages: , ISSN: 2168-0485, DOI: 10.1021/acssuschemeng.8b06715	ACS Sustainable Chemistry & Engineering	2019-07-22
2018	Juraj Paris, NicolÃ¡s RÃosâ€LombardÃa, Francisco MorÃs, Harald GrÃ¶ger, Javier GonzÃ¡lezâ€SabÃn Novel Insights into the Combination of Metalâ€ and Biocatalysis: Cascade Oneâ€Pot Synthesis of Enantiomerically Pure Biaryl Alcohols in Deep Eutectic Solvents published pages: 4417-4423, ISSN: 1867-3880, DOI: 10.1002/cctc.201800768	ChemCatChem 10/19	2019-07-22
2017	Robert Kourist, Javier GonzÃ¡lez-SabÃn, Bettina Siebers, Mattijs Julsing Editorial: Applied Microbiology for Chemical Syntheses published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.01931	Frontiers in Microbiology 8	2019-07-22
2018	Raquel S. Correia Cordeiro, Junichi Enoki, Florian Busch, Carolin MÃ¼gge, Robert Kourist Cloning and characterization of a new delta-specific l-leucine dioxygenase from Anabaena variabilis published pages: 68-74, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2018.07.038	Journal of Biotechnology 284	2019-07-22
2019	Raquel S. Correiaâ€…Cordeiro, NicolÃ¡s RÃos-LombardÃa, Francisco MorÃs, Robert Kourist, Javier GonzÃ¡lez-SabÃn One-Pot Transformation of Ketoximes into Optically Active Alcohols and Amines by Sequential Action of Laccases and Ketoreductases or Ï‰-Transaminases published pages: 1272-1277, ISSN: 1867-3880, DOI: 10.1002/cctc.201801900	ChemCatChem 11/4	2019-07-22
2018	Lisa Marx, NicolÃ¡s RÃos-LombardÃa, Judith F. Farnberger, Wolfgang Kroutil, Ana I. BenÃtez-Mateos, Fernando LÃ³pez-Gallego, Francisco MorÃs, Javier GonzÃ¡lez-SabÃn, Per Berglund Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases published pages: 2157-2165, ISSN: 1615-4150, DOI: 10.1002/adsc.201701485	Advanced Synthesis & Catalysis 360/11	2019-07-22
2018	Federica Ruggieri, Luuk M. vanâ€…Langen, Derek T. Logan, BjÃ¶rn Walse, Per Berglund Transaminase-Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions published pages: 5012-5018, ISSN: 1867-3880, DOI: 10.1002/cctc.201801049	ChemCatChem 10/21	2019-07-22
2019	Wuyuan Zhang, Elena Fernandez Fueyo, Frank Hollmann, Laura Leemans Martin, Milja Pesic, Rainer Wardenga, Matthias HÃ¶hne, Sandy Schmidt Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization published pages: 80-84, ISSN: 1434-193X, DOI: 10.1002/ejoc.201801692	European Journal of Organic Chemistry 2019/1	2019-07-22
2019	Elia Calderini, Julia Wessel, Philipp SÃ¼ss, Patrick Schrepfer, Rainer Wardenga, Anett Schallmey Selective Ring-Opening of Di-substituted Epoxides Catalysed by Halohydrin Dehalogenases published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201900103	ChemCatChem	2019-07-22
2016	NicolÃ¡s RÃos-LombardÃa, Cristian Vidal, Elisa Liardo, Francisco MorÃs, JoaquÃn GarcÃa-Ãlvarez, Javier GonzÃ¡lez-SabÃn From a Sequential to a Concurrent Reaction in Aqueous Medium: Ruthenium-Catalyzed Allylic Alcohol Isomerization and Asymmetric Bioreduction published pages: 8691-8695, ISSN: 1433-7851, DOI: 10.1002/anie.201601840	Angewandte Chemie International Edition 55/30	2019-07-22
2018	Elisa Liardo, NicolÃ¡s RÃos-LombardÃa, Francisco MorÃs, Javier GonzÃ¡lez-SabÃn, Francisca Rebolledo A Straightforward Deracemization of sec -Alcohols Combining Organocatalytic Oxidation and Biocatalytic Reduction published pages: 3031-3035, ISSN: 1434-193X, DOI: 10.1002/ejoc.201800569	European Journal of Organic Chemistry 2018/23	2019-07-22
2018	Harald GrÃ¶ger, Robert Kourist, Anett Schallmey Achte CeBiTec Research Conference published pages: 904-904, ISSN: 1439-9598, DOI: 10.1002/nadc.20184077274	Nachrichten aus der Chemie 66/9	2019-07-22
2018	Elisa Liardo, Rebeca GonzÃ¡lez-FernÃ¡ndez, NicolÃ¡s RÃos-LombardÃa, Francisco MorÃs, JoaquÃn GarcÃa-Ãlvarez, Victorio Cadierno, Pascale Crochet, Francisca Rebolledo, Javier GonzÃ¡lez-SabÃn Strengthening the Combination between Enzymes and Metals in Aqueous Medium: Concurrent Ruthenium-Catalyzed Nitrile Hydration - Asymmetric Ketone Bioreduction published pages: 4676-4682, ISSN: 1867-3880, DOI: 10.1002/cctc.201801005	ChemCatChem 10/20	2019-07-22
2016	Elisa Liardo, NicolÃ¡s RÃos-LombardÃa, Francisco MorÃs, Javier GonzÃ¡lez-SabÃn, Francisca Rebolledo Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles published pages: 3366-3369, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b01510	Organic Letters 18/14	2019-07-22

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