#	Pagina
attuale pagina	/open-h2020/projects/193313/index.html
-1	/open-h2020/projects/200403/index.html
-2	/open-h2020/projects/211103/index.html
-3	/open-h2020/projects/198375/index.html
-4	/open-h2020/projects/214664/index.html
-5	/open-h2020/projects/193748/index.html
-6	/open-h2020/projects/218262/index.html
-7	/open-h2020/projects/214670/index.html
-8	/open-h2020/projects/194975/index.html
-9	/open-h2020/projects/210293/index.html
-10	/open-h2020/projects/209101/index.html

Opendata, web and dolomites

REGAIN SIGNED

REgeneration of inner ear hair cells with GAmma-secretase INhibitors to regain hearing in patients with sensorineural hearing loss

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

REGAIN project word cloud

Explore the words cloud of the REGAIN project. It provides you a very rough idea of what is the project "REGAIN" about.

adults secretase onset auditory small causes pharmaceutical treatment ethical demonstrated actual gsis locally efficacy meet stone ambition inner demonstration hair capacity disabling biological implants clinical provides indication inhibition ear lasting therapeutic administered safety disease shifting patients first children safe validation dosing approval molecule animal restore hearing systemic break trial millions pharmacological therapy 32 gsi chronic underlying local regenerative effect gamma cells upscaling proof irreversible regeneration notch generation aids regain drugs sensorineural receptors thought candidate worldwide repurpose million preclinical cochlear medical signalling 328 benefits involve limited rely communicable gmp inhibitors regenerate data cell stepping

Project "REGAIN" data sheet

The following table provides information about the project.

Coordinator	AUDION THERAPEUTICS BV Organization address address: LINNAEUSPARKWEG 10-2 city: AMSTERDAM postcode: 1098 EA website: www.audiontherapeutics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://yourhearing.eu
Total cost	5˙834˙340 €
EC max contribution	5˙834˙340 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AUDION THERAPEUTICS BV AUDION THERAPEUTICS BV Organization address address: LINNAEUSPARKWEG 10-2 city: AMSTERDAM postcode: 1098 EA website: www.audiontherapeutics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	1˙821˙330.00
2	Eli Lilly and Company Limited Eli Lilly and Company Limited Organization address address: Lilly House, Priestley Road city: Basingstoke postcode: RG24 9NL website: www.lilly.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Basingstoke)	participant	1˙347˙362.00
3	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	1˙051˙188.00
4	NORDIC BIOSCIENCE CLINICAL DEVELOPMENT A/S NORDIC BIOSCIENCE CLINICAL DEVELOPMENT A/S Organization address address: HERLEV HOVEDGADE 207 city: HERLEV postcode: 2730 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HERLEV)	participant	715˙818.00
5	EBERHARD KARLS UNIVERSITAET TUEBINGEN EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 website: www.uni-tuebingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	participant	331˙250.00
6	ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Organization address address: 6 CHRISTOU LADA STR city: ATHINA postcode: 10561 website: www.elke.uoa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	287˙466.00
7	UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST Organization address address: EUSTON ROAD 250 city: LONDON postcode: NW1 2PG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	153˙151.00
8	TTOPSTART BV TTOPSTART BV Organization address address: EUCLIDESLAAN 1 city: UTRECHT postcode: 3584 BL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	125˙000.00
9	ACCELOVANCE EUROPE BV ACCELOVANCE EUROPE BV Organization address address: VICTORIALAAN 15 city: 'S-HERTOGENBOSCH postcode: 5213 JG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL ('S-HERTOGENBOSCH)	participant	1˙771.00

Map

Project objective

Hearing loss is a chronic non-communicable disease disabling over 328 million adults, and 32 million children worldwide. Sensorineural hearing loss due to loss of auditory hair cells was long thought to be irreversible. However, recent animal studies have demonstrated that pharmacological inhibition of cell signalling via Notch receptors using gamma-secretase inhibitors (GSIs) can regenerate hair cells and partially restore hearing capacity. This novel therapeutic concept provides the first promising lead for actual treatment of hearing loss. Clinical validation of these findings is the next crucial stepping stone in the development of a regenerative therapy for hearing loss. The ambition of REGAIN is to repurpose a GSI molecule for this indication by shifting from systemic to local treatment. The objective of the REGAIN project is to demonstrate and exploit the efficacy of locally administered GSIs to improve hearing through regeneration of inner ear hair cells with a lasting effect. The project will involve 1) the upscaling of GMP production of the clinical GSI candidate, 2) the generation of preclinical data on GSI dosing and local safety, 3) medical ethical clinical trial approval and 4) the demonstration of proof of concept for GSI for treatment of patients with recent onset sensorineural hearing loss. Small molecule drugs targeting the underlying biological causes of hearing loss in a safe way are expected to meet a real medical need for millions of patients, who currently rely on the limited benefits provided by hearing aids or cochlear implants. The partners involved in REGAIN represent the current state of the art in regenerative hearing loss research in the EU. REGAIN will break through that current state of the art, and will advance the first highly promising pharmaceutical treatment of hearing loss through clinical testing.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REGAIN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "REGAIN" are provided by the European Opendata Portal: CORDIS opendata.