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INTRAHETEROSEQ SIGNED

Molecular characterization of the role of intra-tumor heterogeneity in cancer progression and metastasis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INTRAHETEROSEQ project word cloud

Explore the words cloud of the INTRAHETEROSEQ project. It provides you a very rough idea of what is the project "INTRAHETEROSEQ" about.

cells heterogeneity somatically impossible caused advantage mutant remarkable characterizing made modified behavior identification modification patients cell finely clonal anti progress sequencing metastasis decades generation genetically mouse tumors technologies transcriptomic posterior genetic samples treatment genomes genome cancer extremely tissue responsible malignancies carry genomic time characterization pancreatic respect specificity conferring strategies human molecular metastatic followed genes biology alleles vital selective purify systematic evolution uncertain functional advent predisposition exact significance populations model resistance first dna primary efficient offers therapies complete assays mice progression seems diagnosis somatic fall correct tumor last acquired

Project "INTRAHETEROSEQ" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE CANTABRIA Organization address address: AVENIDA DE LOS CASTROS S/N city: SANTANDER postcode: 39005 website: www.unican.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	1˙498˙850 €
EC max contribution	1˙498˙850 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE CANTABRIA UNIVERSIDAD DE CANTABRIA Organization address address: AVENIDA DE LOS CASTROS S/N city: SANTANDER postcode: 39005 website: www.unican.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTANDER)	coordinator	1˙498˙850.00

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Project objective

Cancer is caused by somatically acquired changes in the DNA. Some of these changes fall in “cancer genes”, conferring clonal selective advantage to the cells that carry the mutant alleles. Identifying these genes/pathways is of vital importance for a correct understanding of cancer biology as well as for the diagnosis and treatment of human malignancies. In this respect, the use of genetically modified mice has been extremely useful in the past for characterizing the molecular pathways involved in cancer progression. The remarkable progress made during the last two decades on the genetic modification of mouse genomes offers unique opportunities to investigate different aspects of tumor molecular behavior, impossible to study on human samples. Recently, the advent of next-generation sequencing technologies has provided new strategies for the systematic genome-wide identification of somatic changes in cancer cell genomes. Using these technologies, we and others have characterized the high intra-tumor heterogeneity observed in some human tumors. Although the exact significance of this heterogeneity is uncertain, it seems to be responsible for key aspects in the management of cancer patients such as metastasis predisposition and tissue specificity or treatment resistance. Taking advantage of next-generation sequencing, we propose to finely characterize the intra-tumor heterogeneity evolution during the progression of tumors induced in a mouse model of pancreatic cancer, as well as, for the first time, to purify the different cell populations these primary tumors are composed of. A complete genomic and transcriptomic characterization of these populations followed by posterior functional assays will help us to identify the genes/pathways involved in tumor progression as well as metastatic potential and its tissue specificity. This new knowledge could finally contribute to a better understanding of cancer and to the design of more efficient anti-tumor therapies

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The information about "INTRAHETEROSEQ" are provided by the European Opendata Portal: CORDIS opendata.