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SCORA SIGNED

A systematic characterization of human regulatory architectures and their determinants of regulatory activity

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SCORA project word cloud

Explore the words cloud of the SCORA project. It provides you a very rough idea of what is the project "SCORA" about.

careful genes characterization phenotypic dynamic modeling disease genome time unknown transcription confound coding alone transcriptional correct inference unprecedented single conformations computational insights systematically function genetic spatio expression ultimately outcomes model activation appropriate delineate flexibility knowing gene differentiation mostly robustness homeostasis link co data levels date despite temporal functional enhancers understand kinds dna chromatin classifier cell variation regulate experimental modes interpretation fragmented regulation specificity regulatory permits shown determines mechanisms architectures linking enhancer variations output clear distinguishing promoter assays dysregulation restricted accurate susceptibility

Project "SCORA" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://anderssonlab.org
Total cost	1˙436˙292 €
EC max contribution	1˙436˙292 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	1˙249˙225.00
2	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	103˙590.00
3	ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY Organization address address: 845 SHERBROOKE STREET WEST city: MONTREAL postcode: H3A0G4 website: www.mcgill.ca contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CA (MONTREAL)	participant	60˙352.00
4	KLINIKUM DER UNIVERSITAET ZU KOELN KLINIKUM DER UNIVERSITAET ZU KOELN Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 website: www.uk-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	23˙125.00

Map

Project objective

Enhancers control the correct spatio-temporal activation of gene expression. A comprehensive characterization of the properties and regulatory activities of enhancers as well as their target genes is therefore crucial to understand the regulation and dysregulation of differentiation, homeostasis and cell type specificity. Genome-wide chromatin assays have provided insight into the properties and complex architectures by which enhancers regulate genes, but the understanding of their mechanisms is fragmented and their regulatory targets are mostly unknown. Several factors may confound the inference and interpretation of regulatory enhancer activity. There are likely many kinds of regulatory architectures with distinct levels of output and flexibility. Despite this, most state-of-the-art genome-wide studies only consider a single model. In addition, chromatin-based analysis alone does not provide clear insight into function or activity. This project aims to systematically characterize enhancer architectures and delineate what determines their: (1) restricted spatio-temporal activity; (2) robustness to regulatory genetic variation; and (3) dynamic activities over time. My work has shown enhancer transcription to be the most accurate classifier of enhancer activity to date. This data permits unprecedented modeling of regulatory architectures via enhancer-promoter co-expression linking. Careful computational analysis of such data from appropriate experimental systems has a great potential for distinguishing the different modes of regulation and their functional impact. The outcomes have great potential for providing us with new insights into mechanisms of transcriptional regulation. The results will be particularly relevant to interpretation of regulatory genetic variations. Ultimately, knowing the characteristics and conformations of enhancer architectures will increase our ability to link variation in non-coding DNA to phenotypic outcomes like disease susceptibility.

Publications

List of publications.
year	authors and title	journal	last update
2018	Nataliya Petryk, Maria Dalby, Alice Wenger, Caroline B. Stromme, Anne Strandsby, Robin Andersson, Anja Groth MCM2 promotes symmetric inheritance of modified histones during DNA replication published pages: 1389-1392, ISSN: 0036-8075, DOI: 10.1126/science.aau0294	Science 361/6409	2020-04-14
2018	Mette Boyd, Malte Thodberg, Morana Vitezic, Jette Bornholdt, Kristoffer Vitting-Seerup, Yun Chen, Mehmet Coskun, Yuan Li, Bobby Zhao Sheng Lo, Pia Klausen, Pawel Jan Schweiger, Anders Gorm Pedersen, Nicolas Rapin, Kerstin Skovgaard, Katja Dahlgaard, Robin Andersson, Thilde Bagger Terkelsen, Berit Lilje, Jesper Thorvald Troelsen, Andreas Munk Petersen, Kim Bak Jensen, Ismail GÃ¶genur, Peter Thielsen, Jakob Benedict Seidelin, Ole Haagen Nielsen, Jacob Tveiten Bjerrum, Albin Sandelin Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03766-z	Nature Communications 9/1	2020-04-14
2018	Niels Grarup, Ida Moltke, Mette K. Andersen, Maria Dalby, Kristoffer Vitting-Seerup, Timo Kern, Yuvaraj Mahendran, Emil JÃ¸rsboe, Christina V. L. Larsen, Inger K. Dahl-Petersen, Arthur Gilly, Daniel Suveges, George Dedoussis, Eleftheria Zeggini, Oluf Pedersen, Robin Andersson, Peter Bjerregaard, Marit E. JÃ¸rgensen, Anders Albrechtsen, Torben Hansen Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes published pages: 172-174, ISSN: 1061-4036, DOI: 10.1038/s41588-017-0022-7	Nature Genetics 50/2	2020-04-14
2016	Jenna Persson, Babett Steglich, Agata Smialowska, Mette Boyd, Jette Bornholdt, Robin Andersson, Catherine Schurra, Benoit Arcangioli, Albin Sandelin, Olaf Nielsen, Karl Ekwall Regulating retrotransposon activity through the use of alternative transcription start sites published pages: 753-768, ISSN: 1469-221X, DOI: 10.15252/embr.201541866	EMBO reports 17/5	2020-04-14
2018	Sarah Rennie, Maria Dalby, Marta Lloret-Llinares, Stylianos Bakoulis, Christian DalagerÂ VaagensÃ¸, Torben HeickÂ Jensen, Robin Andersson Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky244	Nucleic Acids Research	2020-04-14
2018	J. Kenneth Baillie, Andrew Bretherick, Christopher S. Haley, Sara Clohisey, Alan Gray, Lucile P. A. Neyton, Jeffrey Barrett, Eli A. Stahl, Albert Tenesa, Robin Andersson, J. Ben Brown, Geoffrey J. Faulkner, Marina Lizio, Ulf Schaefer, Carsten Daub, Masayoshi Itoh, Naoto Kondo, Timo Lassmann, Jun Kawai, Damian Mole, Vladimir B. Bajic, Peter Heutink, Michael Rehli, Hideya Kawaji, Albin Sandelin, Harukazu Suzuki, Jack Satsangi, Christine A. Wells, Nir Hacohen, Thomas C. Freeman, Yoshihide Hayashizaki, Piero Carninci, Alistair R. R. Forrest, David A. Hume Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease published pages: e1005934, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1005934	PLOS Computational Biology 14/3	2020-04-14
2018	Sarah Rennie, Maria Dalby, Lucas van Duin, Robin Andersson Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02798-1	Nature Communications 9/1	2020-04-14
2015	Robin Andersson, Yun Chen, Leighton Core, JohnÂ T. Lis, Albin Sandelin, TorbenÂ Heick Jensen Human Gene Promoters Are Intrinsically Bidirectional published pages: 346-347, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2015.10.015	Molecular Cell 60/3	2020-04-14
2016	Yun Chen, Athma A Pai, Jan Herudek, Michal Lubas, Nicola Meola, Aino I JÃ¤rvelin, Robin Andersson, Vicent Pelechano, Lars M Steinmetz, Torben Heick Jensen, Albin Sandelin Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters published pages: 984-994, ISSN: 1061-4036, DOI: 10.1038/ng.3616	Nature Genetics 48/9	2020-04-14
2015	Robin Andersson, Albin Sandelin, Charles G. Danko A unified architecture of transcriptional regulatory elements published pages: 426-433, ISSN: 0168-9525, DOI: 10.1016/j.tig.2015.05.007	Trends in Genetics 31/8	2020-04-14

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