Explore the words cloud of the ClickGene project. It provides you a very rough idea of what is the project "ClickGene" about.
The following table provides information about the project.
Coordinator |
DUBLIN CITY UNIVERSITY
Organization address contact info |
Coordinator Country | Ireland [IE] |
Project website | http://www.clickgene.eu |
Total cost | 3˙556˙990 € |
EC max contribution | 3˙556˙990 € (100%) |
Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
Code Call | H2020-MSCA-ITN-2014 |
Funding Scheme | MSCA-ITN-ETN |
Starting year | 2015 |
Duration (year-month-day) | from 2015-01-01 to 2018-12-31 |
Take a look of project's partnership.
Gene therapy is expected to play a key role in next-generation medicine by correcting the underlying genetic causes of disease, thereby facilitating personalised medicine. Current gene therapy methods possess undesirable side effects, including insertional mutagenesis, toxicity, low efficiency and off-target cutting. Questions also remain regarding the optimal methods for delivering nucleases into cells and tissues. These limitations will be addressed through the original and innovative approach of the ClickGene network.
ClickGene’s research objectives are to train 14 ESRs in the field of biomaterials development with specific focus on, i.) site-selective genetic engineering, ii.) liposomal nanoparticle drug delivery, and iii.) optogenetic diagnostic probes for epigenetic base detection. Most of our academic partners are key members of COST Action CM1201: Biomimetic Radical Chemistry and all have outstanding international reputations as scientific leaders in their field. This COST Action will play a vital role in both networking and training elements of ClickGene, and in combination with transferable skills training, intersectorial and cross-disciplinary secondment, and industry targeted workshops, the education of biomaterials chemists with expertise in click-chemistry and cutting edge application areas of gene therapy, nanotechnology and biological diagnostics will be achieved.
The training provided will match the skills required by next-generation research leaders in biopharmaceutical, nanotechnology, biodiagnostic and other industries. Allied to academic strength in this network, ClickGene features highlycompetitive industry partners with expertise in commercialisation of nucleic acid click-chemistry (baseclick, ATDBio) and liposomal and lipidome technology (LipiNutraGen). Thus, synergy between both commercial and academic partners will enable ESRs to develop gene-targeted technology within a highly productive, engaging, and exciting training network.
Summer School “Enzymatic Chemical Nucleases†| Other | 2019-06-06 15:52:33 |
SCNAC conference in Ceske Krumlov 2018 | Other | 2019-06-06 15:52:37 |
Video | Websites, patent fillings, videos etc. | 2019-06-06 15:52:34 |
 FAQ sessions in schools | Websites, patent fillings, videos etc. | 2019-06-06 15:52:34 |
Website | Websites, patent fillings, videos etc. | 2019-03-04 11:00:29 |
Social media | Websites, patent fillings, videos etc. | 2019-02-12 12:35:33 |
Take a look to the deliverables list in detail: detailed list of ClickGene deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Alessandro Panattoni, Radek Pohl, Michal Hocek Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne–Azide 1,3-Dipolar Cycloaddition published pages: 3962-3965, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b01533 |
Organic Letters 20/13 | 2019-03-11 |
2018 |
Ilenia Manuguerra, Stefano Croce, Afaf H. El-Sagheer, Abhichart Krissanaprasit, Tom Brown, Kurt V. Gothelf, Antonio Manetto Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures published pages: 4529-4532, ISSN: 1359-7345, DOI: 10.1039/c8cc00738a |
Chemical Communications 54/36 | 2019-03-11 |
2018 |
Gianluca Toniolo, Maria Louka, Georgia Menounou, Nicolò Zuin Fantoni, George Mitrikas, Eleni K. Efthimiadou, Annalisa Masi, Massimo Bortolotti, Letizia Polito, Andrea Bolognesi, Andrew Kellett, Carla Ferreri, Chryssostomos Chatgilialoglu [Cu(TPMA)(Phen)](ClO 4 ) 2 : Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity published pages: 15952-15965, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b02526 |
ACS Omega 3/11 | 2019-03-11 |
2018 |
Michael Stadlmeier, Jana Bogena, Miriam Wallner, Martin Wühr, Thomas Carell A Sulfoxide-Based Isobaric Labelling Reagent for Accurate Quantitative Mass Spectrometry published pages: 2958-2962, ISSN: 1433-7851, DOI: 10.1002/anie.201708867 |
Angewandte Chemie International Edition 57/11 | 2019-03-11 |
2018 |
Ilenia Manuguerra, Stefano Croce, Afaf H. El-Sagheer, Abhichart Krissanaprasit, Tom Brown, Kurt V. Gothelf, Antonio Manetto Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures published pages: 4529-4532, ISSN: 1359-7345, DOI: 10.1039/c8cc00738a |
Chemical Communications 54/36 | 2019-03-20 |
2017 |
Raddaoui, Nada; Stazzoni, Samuele; Möckl, Leonhard; Viverge, Bastien; Geiger, Florian; Engelke, Hanna; Bräuchle, Christoph; Carell, Thomas Dendrimer-based signal amplification of click-labelled DNA in situ published pages: 1716-1720, ISSN: 1439-4227, DOI: 10.5282/ubm/epub.60576 |
Chembiochem 18/17 | 2019-03-20 |
2018 |
Creina Slator, Zara Molphy, Vickie McKee, Conor Long, Tom Brown, Andrew Kellett Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination published pages: 2733-2750, ISSN: 0305-1048, DOI: 10.1093/nar/gky105 |
Nucleic Acids Research 46/6 | 2019-03-13 |
2017 |
Giorgia Giacometti, Marina Marini, Kyriakos Papadopoulos, Carla Ferreri, Chryssostomos Chatgilialoglu trans-Double Bond-Containing Liposomes as Potential Carriers for Drug Delivery published pages: 2082, ISSN: 1420-3049, DOI: 10.3390/molecules22122082 |
Molecules 22/12 | 2019-03-11 |
2017 |
Nada Raddaoui, Samuele Stazzoni, Leonhard Möckl, Bastien Viverge, Florian Geiger, Hanna Engelke, Christoph Bräuchle, Thomas Carell Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ published pages: 1716-1720, ISSN: 1439-4227, DOI: 10.1002/cbic.201700209 |
ChemBioChem 18/17 | 2019-03-13 |
2017 |
Paraskevi Prasinou, Ioannis Dafnis, Giorgia Giacometti, Carla Ferreri, Angeliki Chroni, Chryssostomos Chatgilialoglu Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells published pages: 1967-1973, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2017.07.001 |
Biochimica et Biophysica Acta (BBA) - Biomembranes 1859/10 | 2019-03-13 |
2018 |
Javier Amézaga, Sara Arranz, Ander Urruticoechea, Gurutze Ugartemendia, Aitziber Larraioz, Maria Louka, Matxalen Uriarte, Carla Ferreri, Itziar Tueros Altered Red Blood Cell Membrane Fatty Acid Profile in Cancer Patients published pages: 1853, ISSN: 2072-6643, DOI: 10.3390/nu10121853 |
Nutrients 10/12 | 2019-03-13 |
2018 |
Gianluca Toniolo, Eleni K. Efthimiadou, George Kordas, Chryssostomos Chatgilialoglu Development of multi-layered and multi-sensitive polymeric nanocontainers for cancer therapy: in vitro evaluation published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32890-5 |
Scientific Reports 8/1 | 2019-03-11 |
2017 |
Giorgia Giacometti, Carla Ferreri, Anna Sansone, Chryssostomos Chatgilialoglu, Carla Marzetti, Ellas Spyratou, Alexandros G. Georgakilas, Marina Marini, Provvidenza M. Abruzzo, Alessandra Bolotta, Alessandro Ghezzo, Renato Minguzzi, Annio Posar, Paola Visconti High predictive values of RBC membrane-based diagnostics by biophotonics in an integrated approach for Autism Spectrum Disorders published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-10361-7 |
Scientific Reports 7/1 | 2019-03-11 |
2018 |
Natasha McStay, Anthony M. Reilly, Nicholas Gathergood, Andrew Kellett Efficient DNA Condensation by a C 3 â€Symmetric Codeine Scaffold published pages: 38-42, ISSN: 2192-6506, DOI: 10.1002/cplu.201800480 |
ChemPlusChem 84 | 2019-03-11 |
2019 |
Nicoló Zuin Fantoni, Zara Molphy, Creina Slator, Georgia Menounou, Gianluca Toniolo, George Mitrikas, Vickie McKee, Chryssostomos Chatgilialoglu, Andrew Kellett Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease published pages: 221-237, ISSN: 0947-6539, DOI: 10.1002/chem.201804084 |
Chemistry - A European Journal 25/1 | 2019-03-11 |
2016 |
Su, Meng ; Kirchner, Angie ; Stazzoni, Samuele; Müller, Markus ; Wagner, Mirko; Schröder, Arne; Carell, Thomas 5-Formylcytosin ist vermutlich eine semi-permanente Base an definierten Genompositionen published pages: 11974-11978, ISSN: 1521-3757, DOI: 10.5282/ubm/epub.60565 |
Angewandte Chemie 128/39 | 2019-03-20 |
2018 |
Michael Stadlmeier, Jana Bogena, Miriam Wallner, Martin Wühr, Thomas Carell Ein auf Sulfoxid basierendes, isobares Derivatisierungsreagens für die präzise quantitative Massenspektrometrie published pages: 3008-3013, ISSN: 0044-8249, DOI: 10.1002/ange.201708867 |
Angewandte Chemie 130/11 | 2019-03-18 |
2018 |
Sarah Walsh, Afaf Helmy El-Sagheer, Tom Brown Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above published pages: 7681-7687, ISSN: 2041-6520, DOI: 10.1039/c8sc02418a |
Chemical Science 9/39 | 2019-03-11 |
2016 |
Anna Sansone, Evanthia Tolika, Maria Louka, Valentina Sunda, Simone Deplano, Michele Melchiorre, Dimitrios Anagnostopoulos, Chryssostomos Chatgilialoglu, Cesare Formisano, Rosa Di Micco, Maria Rosaria Faraone Mennella, Carla Ferreri Hexadecenoic Fatty Acid Isomers in Human Blood Lipids and Their Relevance for the Interpretation of Lipidomic Profiles published pages: e0152378, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0152378 |
PLOS ONE 11/4 | 2019-05-28 |
2015 |
A. Kellett, N. Fantoni, T. Lauria Genome Engineering with Synthetic Copper Nucleases published pages: 2623-2626, ISSN: 0936-5214, DOI: 10.1055/s-0035-1560709 |
Synlett 26/19 | 2019-05-28 |
2016 |
Ján MatyaÅ¡ovský, Pavla PerlÃková, Vincent Malnuit, Radek Pohl, Michal Hocek 2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove published pages: 15856-15859, ISSN: 1433-7851, DOI: 10.1002/anie.201609007 |
Angewandte Chemie International Edition 55/51 | 2019-05-28 |
2017 |
Creina Slator, Zara Molphy, Vickie McKee, Andrew Kellett Triggering autophagic cell death with a di-manganese(II) developmental therapeutic published pages: 150-161, ISSN: 2213-2317, DOI: 10.1016/j.redox.2017.01.024 |
Redox Biology 12 | 2018-10-24 |
2017 |
Carla Ferreri, Annalisa Masi, Anna Sansone, Giorgia Giacometti, Anna Larocca, Georgia Menounou, Roberta Scanferlato, Silvia Tortorella, Domenico Rota, Marco Conti, Simone Deplano, Maria Louka, Anna Maranini, Arianna Salati, Valentina Sunda, Chryssostomos Chatgilialoglu Fatty Acids in Membranes as Homeostatic, Metabolic and Nutritional Biomarkers: Recent Advancements in Analytics and Diagnostics published pages: 1, ISSN: 2075-4418, DOI: 10.3390/diagnostics7010001 |
Diagnostics 7/1 | 2019-05-28 |
2016 |
Dmytro Dziuba, Petr PospÃÅ¡il, Ján MatyaÅ¡ovský, Jiřà Brynda, Dana Nachtigallová, LubomÃr RulÃÅ¡ek, Radek Pohl, Martin Hof, Michal Hocek Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions published pages: 5775-5785, ISSN: 2041-6520, DOI: 10.1039/C6SC02548J |
Chem. Sci. 7/9 | 2019-05-28 |
2018 |
Gianluca Toniolo, Maria Louka, Georgia Menounou, Nicolò Zuin Fantoni, George Mitrikas, Eleni K. Efthimiadou, Annalisa Masi, Massimo Bortolotti, Letizia Polito, Andrea Bolognesi, Andrew Kellett, Carla Ferreri, Chryssostomos Chatgilialoglu [Cu(TPMA)(Phen)](ClO 4 ) 2 : Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity published pages: 15952-15965, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b02526 |
ACS Omega 3/11 | 2019-05-28 |
2019 |
Nicoló Zuin Fantoni, Zara Molphy, Creina Slator, Georgia Menounou, Gianluca Toniolo, George Mitrikas, Vickie McKee, Chryssostomos Chatgilialoglu, Andrew Kellett Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease published pages: 221-237, ISSN: 0947-6539, DOI: 10.1002/chem.201804084 |
Chemistry - A European Journal 25/1 | 2019-05-28 |
2016 |
Marco Conti, Roberta Scanferlato, Maria Louka, Anna Sansone, Carla Marzetti, Carla Ferreri Building up spectral libraries for mapping erythrocytes by hyperspectral dark field microscopy published pages: 175-184, ISSN: 2212-8808, DOI: 10.3233/BSI-160133 |
Biomedical Spectroscopy and Imaging 5/2 | 2019-05-28 |
2016 |
Ján MatyaÅ¡ovský, Pavla PerlÃková, Vincent Malnuit, Radek Pohl, Michal Hocek 2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove published pages: 16088–16091, ISSN: 1521-3757, DOI: 10.1002/ange.201609007 |
Angewandte Chemie 128/51 | 2019-05-28 |
2016 |
Meng Su, Angie Kirchner, Samuele Stazzoni, Markus Müller, Mirko Wagner, Arne Schröder, Thomas Carell 5-Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites published pages: 11797-11800, ISSN: 1433-7851, DOI: 10.1002/anie.201605994 |
Angewandte Chemie International Edition 55/39 | 2019-05-28 |
2016 |
Hana Cahová, Alessandro Panattoni, Pavel Kielkowski, JindÅ™ich FanfrlÃk, Michal Hocek 5-Substituted Pyrimidine and 7-Substituted 7-Deazapurine dNTPs as Substrates for DNA Polymerases in Competitive Primer Extension in the Presence of Natural dNTPs published pages: 3165-3171, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b00714 |
ACS Chemical Biology 11/11 | 2019-05-28 |
2018 |
Sarah Walsh, Afaf Helmy El-Sagheer, Tom Brown Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above published pages: 7681-7687, ISSN: 2041-6520, DOI: 10.1039/c8sc02418a |
Chemical Science 9/39 | 2019-05-28 |
2018 |
Gianluca Toniolo, Eleni K. Efthimiadou, George Kordas, Chryssostomos Chatgilialoglu Development of multi-layered and multi-sensitive polymeric nanocontainers for cancer therapy: in vitro evaluation published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32890-5 |
Scientific Reports 8/1 | 2019-05-28 |
2018 |
Alessandro Panattoni, Radek Pohl, Michal Hocek Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne–Azide 1,3-Dipolar Cycloaddition published pages: 3962-3965, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b01533 |
Organic Letters 20/13 | 2019-05-28 |
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