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CLOSPORE SIGNED

UNDERSTANDING THE CLOSTRIDIUM SPORE, A PREREQUISTE FOR DISEASE INTERVENTIONS AND EXPLOITATION

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CLOSPORE project word cloud

Explore the words cloud of the CLOSPORE project. It provides you a very rough idea of what is the project "CLOSPORE" about.

companies perfringens toxins linked bacterial entirely vegetative little pivotal life interdisciplinary innovative botulinum training capacity fuels despite developmental endotoxins endospores toxin crucially benign return chemical heart spores treating forms cells intimately difficile cytotoxins pathogenesis deficiency genus infection cancer diseases facetted clostridium spread producing spore industrially germination points intersectorial manner foodstuff neurotoxins ascribed single chemicals tackle food efforts intervention accordingly earth pooling universities coherence sporulation poisoning leaders resistant notorious eg species world contamination create devastating pathogens fragmented play lies dormant sustainably clostridial clospore big whilst regulation majority pathogenic societal clostridia

Project "CLOSPORE" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF NOTTINGHAM Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD website: www.nottingham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.clostridia.net/clospore/
Total cost	3˙910˙777 €
EC max contribution	3˙910˙777 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF NOTTINGHAM THE UNIVERSITY OF NOTTINGHAM Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD website: www.nottingham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	coordinator	819˙863.00
2	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	538˙290.00
3	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	525˙751.00
4	NIZO FOOD RESEARCH BV NIZO FOOD RESEARCH BV Organization address address: KERNHEMSEWEG 2 city: EDE GLD postcode: 6718 ZB website: www.nizo.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EDE GLD)	participant	510˙748.00
5	PURAC BIOCHEM BV PURAC BIOCHEM BV Organization address address: ARKELSEDIJK 46 city: GORINCHEM postcode: 4206AC website: www.puracbiomaterials.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GORINCHEM)	participant	510˙748.00
6	UNIVERSIDADE NOVA DE LISBOA UNIVERSIDADE NOVA DE LISBOA Organization address address: CAMPUS DE CAMPOLIDE city: LISBOA postcode: 1099 085 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	476˙712.00
7	Green Biologics Ltd. Green Biologics Ltd. Organization address address: 45A Western Avenue, Milton Park city: Abingdon postcode: OX144RU website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Abingdon)	participant	273˙287.00
8	STICHTING WAGENINGEN RESEARCH STICHTING WAGENINGEN RESEARCH Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	participant	255˙374.00
9	INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA Organization address address: Avenida da Republica, Estacao Agronomica Nacional city: OEIRAS postcode: 2784-505 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (OEIRAS)	participant	0.00
10	ASTELLAS PHARMA EUROPE LTD ASTELLAS PHARMA EUROPE LTD Organization address address: 2000 HILLSWOOD DRIVE city: CHERTSEY postcode: KT16 0RS website: www.astellas.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CHERTSEY)	partner	0.00
11	Atria Finland Ltd Atria Finland Ltd Organization address address: Atriantie 1 city: Kuopio postcode: 60060 ATRIA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Kuopio)	partner	0.00
12	BIOMERIEUX SA BIOMERIEUX SA Organization address address: Chemin de l'Orme city: Marcy l'Etoile postcode: 69280 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Marcy l'Etoile)	partner	0.00
13	HKScan Ltd HKScan Ltd Organization address address: n.a. city: Turku postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Turku)	partner	0.00
14	Ipsen Pharmaceuticals Ipsen Pharmaceuticals Organization address address: n.a. city: Oxford postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Oxford)	partner	0.00
15	LANZATECH UK LTD LANZATECH UK LTD Organization address address: HORNDEAN ROAD FOREST HOUSE 3 5 city: BRACKNELL postcode: RG12 0XQ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRACKNELL)	partner	0.00
16	METABOLIC EXPLORER SA METABOLIC EXPLORER SA Organization address address: BIOPOLE CLERMONT LIMAGNE city: SAINT BEAUZIRE postcode: 63360 website: www.metabolic-explorer.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SAINT BEAUZIRE)	partner	0.00
17	Saarioinen Saarioinen Organization address address: Järvensivuntie 1 city: TAMPERE postcode: FI-33101 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TAMPERE)	partner	0.00
18	Snellmanin Lihanjalostus Oy Snellmanin Lihanjalostus Oy Organization address address: n.a. city: Pietarsaari postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Pietarsaari)	partner	0.00

Map

Project objective

Bacterial endospores are the most resistant life-forms on earth and the most important single feature of the genus Clostridium. Thus, whilst the pathogenesis of its notorious pathogens (C. botulinum, C. perfringens and C. difficile) is ascribed to the devastating toxins produced (neurotoxins, endotoxins and cytotoxins), it is their capacity to produce spores that lies at the heart of the diseases they cause. This is because spores play the pivotal role in the spread of infection (eg, C. difficile) and in foodstuff contamination and food poisoning (eg, C. botulinum and C. perfringens). The processes of spore formation (sporulation) and germination (return of the dormant spore to toxin-producing, vegetative cells), therefore, represent key intervention points. On the other hand, the majority of clostridia are entirely benign and can sustainably produce all manner of useful chemicals and fuels. Crucially, the regulation of chemical production is intimately linked to that of sporulation. Spores of benign species may also be used as a delivery system for treating cancer. Yet, despite the spore’s importance, little is known of the developmental processes of sporulation and germination. This is because research and training efforts on Clostridium spores are fragmented and there is no coherence between researchers working on pathogenic and industrially important species. CLOSPORE will address this deficiency by pooling the resources of Europe’s leading universities, research organisations and companies, to create an intersectorial Research and Training Programme that is multi-facetted, interdisciplinary and focused on clostridial spores. Accordingly, CLOSPORE will produce the innovative, applied research leaders of the future, able to tackle the big societal challenges facing Europe and the world.

Deliverables

List of deliverables.
Conditionally CDEPTsporulating strain	Other	2019-07-30 15:26:45
Final Report	Documents, reports	2019-07-30 15:26:45
Final Conference Proceedings	Other	2019-07-30 15:26:45
Increased understanding of disease	Other	2019-07-30 15:26:45
Characterised sporulation genes	Other	2019-07-30 15:26:45
Submission of Doctorate Thesis	Other	2019-07-30 15:26:45
Spore regulators common to toxins	Other	2019-07-30 15:26:45
Ethics	Other	2019-07-30 15:26:45
Promotional material distributed	Other	2019-07-30 15:26:45
CLOSPORE website	Websites, patent fillings, videos etc.	2019-07-30 15:26:44
Mid-term Conference	Other	2019-07-30 15:26:44
New sporulation/germination genes	Other	2019-07-30 15:26:44
First ESR scientific presentation	Other	2019-07-30 15:26:44
Sporulation Mutants Isolated	Other	2019-07-30 15:26:44
ESRs recruited	Other	2019-07-30 15:26:45
Decision-making at single cell level	Other	2019-07-30 15:26:44
Exemplification of ACE technology	Other	2019-07-30 15:26:44
Asporogenous butanol producers	Other	2019-07-30 15:26:44
Social Media Established	Websites, patent fillings, videos etc.	2019-07-30 15:26:45
Germination Mutants Isolated	Other	2019-07-30 15:26:44
Appointment of Supervisory Board	Other	2019-07-30 15:26:45
Universal transposon exemplified	Other	2019-07-30 15:26:44

Take a look to the deliverables list in detail: detailed list of CLOSPORE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	InÃ©s C. CaÃ±adas, Daphne Groothuis, Maria Zygouropoulou, Raquel Rodrigues, Nigel P. Minton RiboCas: A Universal CRISPR-Based Editing Tool for Clostridium published pages: , ISSN: 2161-5063, DOI: 10.1021/acssynbio.9b00075	ACS Synthetic Biology	2019-08-05
2019	Patrick Ingle, Daphne Groothuis, Peter Rowe, He Huang, Alan Cockayne, Sarah A. Kuehne, Weihong Jiang, Yang Gu, Christopher M. Humphreys, Nigel P. Minton Generation of a fully erythromycin-sensitive strain of Clostridioides difficile using a novel CRISPR-Cas9 genome editing system published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-44458-y	Scientific Reports 9/1	2019-08-05
2018	Jeroen Girwar Koendjbiharie, Kilian Wiersma, Richard van Kranenburg Investigating the Central Metabolism of Clostridium thermosuccinogenes published pages: e00363-18, ISSN: 0099-2240, DOI: 10.1128/AEM.00363-18	Applied and Environmental Microbiology 84/13	2019-07-30
2018	Ioannis Mougiakos, Elleke F Bosma, Joyshree Ganguly, John van der Oost, Richard van Kranenburg Hijacking CRISPR-Cas for high-throughput bacterial metabolic engineering: advances and prospects published pages: 146-157, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2018.01.002	Current Opinion in Biotechnology 50	2019-07-30

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