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BIOGEL

Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

BIOGEL project word cloud

Explore the words cloud of the BIOGEL project. It provides you a very rough idea of what is the project "BIOGEL" about.

undergo 2d interdisciplinary medical coatings implants regeneration temporal focussed interwoven structural topographical templates viability extracellular direct biomedical subunits precursors innovative repair biohybridisation skills biointegrative 3d flexible therapeutic cartilage situ units education diagnostic bone training synthetic translatable incorporation hydrogels body interlink orchestrate international cells chemistries gelation resemble young bioactivities tools rounded spatial biohybrid minimal tissue educate efficient platform interface hydrogel engineer first functional components biogel serve bioactive tailor directed packages living scientists macromolecules nerve matrix mechanical engineering respectively intersectoral invasive clinically follows phd stimuli interaction cell responsive behavior dynamic emphasis efficacy receptor stimulate parts cardiovascular translational integration career

Project "BIOGEL" data sheet

The following table provides information about the project.

Coordinator	DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV Organization address address: FORCKENBECKSTRASSE 50 city: AACHEN postcode: 52074 website: www.dwi.rwth-aachen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.biogel-mariecurie.eu
Total cost	3˙522˙760 €
EC max contribution	3˙522˙760 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2014
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV Organization address address: FORCKENBECKSTRASSE 50 city: AACHEN postcode: 52074 website: www.dwi.rwth-aachen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	coordinator	1˙032˙448.00
2	AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH Organization address address: GIEFINGGASSE 4 city: WIEN postcode: 1210 website: http://www.ait.ac.at/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	511˙868.00
3	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	510˙748.00
4	LIFETEC GROUP BV LIFETEC GROUP BV Organization address address: KENNEDYPLEIN 11 city: EINDHOVEN postcode: 5611 ZS website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	participant	255˙374.00
5	NovioSense BV NovioSense BV Organization address address: TRANSISTORWEG 5 city: Nijmegen postcode: 6534 AT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Nijmegen)	participant	255˙374.00
6	PEPSCAN THERAPEUTICS BV PEPSCAN THERAPEUTICS BV Organization address address: ZUIDERSLUISWEG 2 city: LELYSTAD postcode: 8243 RC website: www.pepscan.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LELYSTAD)	participant	255˙374.00
7	TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL Organization address address: PASEO DE BELEN 11 city: VALLADOLID postcode: 47011 website: www.tpnbt.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALLADOLID)	participant	247˙872.00
8	UNIVERSIDAD DE VALLADOLID UNIVERSIDAD DE VALLADOLID Organization address address: PLAZA SANTA CRUZ 8 PALACIO DE SANTA CRUZ city: VALLADOLID postcode: 47002 website: www.uva.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALLADOLID)	participant	247˙872.00
9	ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS Organization address address: CHARILAOU THERMI ROAD 6 KM city: THERMI THESSALONIKI postcode: 57001 website: www.certh.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (THERMI THESSALONIKI)	participant	205˙826.00
10	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	partner	0.00
11	OSAKA UNIVERSITY OSAKA UNIVERSITY Organization address address: 1-1 Yamadaoka Suita city: OSAKA postcode: 565-0871 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	JP (OSAKA)	partner	0.00
12	Synolyne Pharma Synolyne Pharma Organization address address: RUE HAUTE CLAIRE 4 city: HERSTAL postcode: 4040 website: www.synolyne-pharma.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (HERSTAL)	partner	0.00
13	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP Organization address address: 3451 WALNUT STREET ROOM P 221 city: PHILADELPHIA postcode: 19104 website: www.upenn.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (PHILADELPHIA)	partner	0.00

Map

Project objective

BIOGEL is set up to educate young scientists to develop innovative hydrogel chemistries and systems for biomedical applications. The first objective is to provide a platform for young researchers to undergo a well-rounded PhD education, particularly focussed on translational skills for a career focused in biomedical research and medical technology development. The second objective is to engineer functional and responsive hydrogels, which resemble specific properties of the extracellular matrix. The third objective is (i) to enhance the efficacy of medical devices by 2D biointegrative coatings that direct and orchestrate the interface to living cells and tissue and enable improved integration within the body, (ii) to advance therapeutic measures by 3D templates for tissue repair, and (iii) to enable new diagnostic tools by responsive diagnostic hydrogels. BIOGEL follows an international, interdisciplinary, and intersectoral approach organized in 9 and 8 interwoven work and training packages respectively. The training and research parts are focused on synthetic and biohybrid macromolecules to build clinically translatable hydrogels with specific, application directed bioactivities. In order to enable efficient biohybridisation and minimal invasive application, emphasis is set on in situ gelation of precursors that do not affect the viability of cells and living tissue and that can interlink bioactive subunits to stimulate tissue regeneration, and serve as a functional component in biomedical devices. Structural incorporation of such units must be flexible, dynamic, and responsive to stimuli. This is directed to enhance cell behavior and receptor interaction, tailor the mechanical properties, and enable spatial, temporal, and topographical control of functional components. Translational aspects focus on coatings of medical devices, diagnostic hydrogels, cartilage and bone repair, tissue engineering for cardiovascular implants, and nerve regeneration.

Deliverables

List of deliverables.
Workshop 6	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Newsletters	Documents, reports	2019-09-06 09:59:10
Open ITN day	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Optical characterization methods	Demonstrators, pilots, prototypes	2019-09-06 09:59:09
Workshop 7	Websites, patent fillings, videos etc.	2019-09-06 09:59:10
International conference	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
14 (anticipated) PhD diplomas	Documents, reports	2019-09-06 09:59:10
A Blogspot into the BIOGEL website	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Ambassador Day	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Bicyclic peptides	Demonstrators, pilots, prototypes	2019-09-06 09:59:09
Workshop 4	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Workshop 1	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Workshop 3	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Workshop 2	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Completion of Recruitment	Other	2019-09-06 09:59:09
Summer School	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Workshop 5	Websites, patent fillings, videos etc.	2019-09-06 09:59:09
Design BIOGEL Website	Websites, patent fillings, videos etc.	2019-09-06 09:59:09

Take a look to the deliverables list in detail: detailed list of BIOGEL deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Dominik Bernhagen, Laura De Laporte, Peter Timmerman High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to Î± v Î² 3 , Î± v Î² 5 , and Î± 5 Î² 1 Integrin Receptors published pages: 5991-5997, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b00554	Analytical Chemistry 89/11	2019-09-06
2019	Filippo Cipriani, Dominik Bernhagen, Carmen Garcia-ArÃ©valo, Israel GonzÃ¡lez de Torre, Peter Timmerman, Jose Carlos Rodriguez-Cabello Bicyclic RGD peptides with high integrin Î±_vÎ²₃ and Î±₅Î²₁ affinity promote cell adhesion on elastin-like recombinamers published pages: , ISSN: 1748-6041, DOI: 10.1088/1748-605x/aafd83	Biomedical Materials	2019-09-06
2018	Filippo Cipriani, Melanie KrÃ¼ger, Israel Gonzalez de Torre, Luis Quintanilla Sierra, Matilde Alonso Rodrigo, Linda Kock, JosÃ© Carlos Rodriguez-Cabello Cartilage Regeneration in Preannealed Silk Elastin-Like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform published pages: 4333-4347, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01211	Biomacromolecules 19/11	2019-09-06
2018	Adrian Moreno, Tong Liu, Liang Ding, Irene Buzzacchera, Marina GaliÃ , Martin MÃ¶ller, Christopher J. Wilson, Gerard Lligadas, Virgil Percec SET-LRP in biphasic mixtures of fluorinated alcohols with water published pages: 2313-2327, ISSN: 1759-9954, DOI: 10.1039/c8py00062j	Polymer Chemistry 9/17	2019-09-06
2018	Alicja E. Kownacka, Dovile Vegelyte, Maurits Joosse, Nicoleta Anton, B. Jelle Toebes, Jan Lauko, Irene Buzzacchera, Katarzyna Lipinska, Daniela A. Wilson, Nel Geelhoed-Duijvestijn, Christopher J. Wilson Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating published pages: 4504-4511, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01429	Biomacromolecules 19/11	2019-09-06
2019	Irene Buzzacchera, Qi Xiao, Hong Han, Khosrow Rahimi, Shangda Li, Nina Yu. Kostina, B. Jelle Toebes, Samantha E. Wilner, Martin MÃ¶ller, Cesar Rodriguez-Emmenegger, Tobias Baumgart, Daniela A. Wilson, Christopher J. Wilson, Michael L. Klein, Virgil Percec Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes published pages: 712-727, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01405	Biomacromolecules 20/2	2019-09-06
2018	Nestor Gisbert Quilis, MÃ©dÃ©ric Lequeux, Priyamvada Venugopalan, Imran Khan, Wolfgang Knoll, Souhir Boujday, Marc Lamy de la Chapelle, Jakub Dostalek Tunable laser interference lithography preparation of plasmonic nanoparticle arrays tailored for SERS published pages: 10268-10276, ISSN: 2040-3364, DOI: 10.1039/c7nr08905h	Nanoscale 10/21	2019-09-06
2017	Cesar Rodriguez-Emmenegger, Qi Xiao, Nina Yu. Kostina, Samuel E. Sherman, Khosrow Rahimi, Benjamin E. Partridge, Shangda Li, Dipankar Sahoo, Aracelee M. Reveron Perez, Irene Buzzacchera, Hong Han, Meir Kerzner, Ishita Malhotra, Martin MÃ¶ller, Christopher J. Wilson, Matthew C. Good, Mark Goulian, Tobias Baumgart, Michael L. Klein, Virgil Percec Encoding biological recognition in a bicomponent cell-membrane mimic published pages: 201821924, ISSN: 0027-8424, DOI: 10.1073/pnas.1821924116	Proceedings of the National Academy of Sciences	2019-09-06
2017	Luis P. B. Guerzoni, Jan Bohl, Alexander Jans, Jonas C. Rose, Jens Koehler, Alexander J. C. Kuehne, Laura De Laporte Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules published pages: 1549-1557, ISSN: 2047-4830, DOI: 10.1039/c7bm00322f	Biomaterials Science 5/8	2019-09-06
2017	Irene Buzzacchera, Mariia Vorobii, Nina Yu. Kostina, Andres de los Santos Pereira, TomÃ¡Å¡ Riedel, Michael Bruns, Wojciech Ogieglo, Martin MÃ¶ller, Christopher J. Wilson, Cesar Rodriguez-Emmenegger Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings published pages: 1983-1992, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00516	Biomacromolecules 18/6	2019-09-06
2019	Evgenia Tsanaktsidou, Olga Kammona, Costas Kiparissides On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions published pages: 47-56, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2019.02.024	European Polymer Journal 114	2019-09-06
2018	Qi Xiao, Anna-Kristin Ludwig, Cecilia RomanÃ², Irene Buzzacchera, Samuel E. Sherman, Maria Vetro, Sabine VÃ©rtesy, Herbert Kaltner, Ellen H. Reed, Martin MÃ¶ller, Christopher J. Wilson, Daniel A. Hammer, Stefan Oscarson, Michael L. Klein, Hans-Joachim Gabius, Virgil Percec Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes published pages: E2509-E2518, ISSN: 0027-8424, DOI: 10.1073/pnas.1720055115	Proceedings of the National Academy of Sciences 115/11	2019-09-06
2018	Paul H.J. Kouwer, Paula de Almeida, Onno ven den Boomen, Zaskia H. Eksteen-Akeroyd, Roel Hammink, Maarten Jaspers, Stijn Kragt, Mathijs F.J. Mabesoone, Roeland J.M. Nolte, Alan E. Rowan, Martin G.T.A. Rutten, Vincent A.A. Le Sage, DaniÃ«l C. Schoenmakers, Chengfen Xing, Jialiang Xu Controlling the gelation temperature of biomimetic polyisocyanides published pages: 281-284, ISSN: 1001-8417, DOI: 10.1016/j.cclet.2017.11.002	Chinese Chemical Letters 29/2	2019-09-06
2019	Kaizheng Liu, Silvia M. Mihaila, Alan Rowan, Egbert Oosterwijk, Paul H. J. Kouwer Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization published pages: 826-834, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01445	Biomacromolecules 20/2	2019-09-06
2019	Paula de Almeida, Maarten Jaspers, Sarah Vaessen, Oya Tagit, Giuseppe Portale, Alan E. Rowan, Paul H. J. Kouwer Cytoskeletal stiffening in synthetic hydrogels published pages: 609, ISSN: 2041-1723, DOI: 10.1038/s41467-019-08569-4	Nature Communications 10/1	2019-09-06
2016	Mila I. Svechtarova, Irene Buzzacchera, B. Jelle Toebes, Jan Lauko, Nicoleta Anton, Christopher J. Wilson Sensor Devices Inspired by the Five Senses: A Review published pages: , ISSN: 1040-0397, DOI: 10.1002/elan.201600047	Electroanalysis	2019-09-06

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