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NANOFACTURING

The Development of Medium- and Large-Scale Sustainable Manufacturing Process Platforms for Clinically Compliant Solid Core Nanopharmaceuticals

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NANOFACTURING project word cloud

Explore the words cloud of the NANOFACTURING project. It provides you a very rough idea of what is the project "NANOFACTURING" about.

gnps limited milligram regulatory protected date self enabled hold synthetic scaling nanopharmaceuticals nanoparticles midatech glycan biogune coated platform quantities batches considerable proof lines sub translating inherent facilities translation pilot forming nanomedicine toxic treatments nanomaterials private class therapeutic commercial man formulations trials standards gaps transfer specifications practices inability advantages industrial good infrastructures engineer nanofacturing first interventions expertise manufacture clinical functional successfully patent interfacing efficient smes assays mid developmental qc analytical gmp stakeholders gold shown bottleneck excellence discovery levels progress kilogram multiple manufacturing centres create researched qa

Project "NANOFACTURING" data sheet

The following table provides information about the project.

Coordinator	MIDATECH PHARMA ESPANA SL Organization address address: PARQUE TECNOLOGICO DE BIZKAIA EDIFICIO 800 2A PLANTA city: DERIO postcode: 48160 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://nanofacturing.eu/
Total cost	8˙758˙519 €
EC max contribution	7˙898˙781 € (90%)
Programme	1. H2020-EU.2.1.2.1. (Developing next generation nanomaterials, nanodevices and nanosystems)
Code Call	H2020-NMP-PILOTS-2014
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-02-01 to 2019-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MIDATECH PHARMA ESPANA SL MIDATECH PHARMA ESPANA SL Organization address address: PARQUE TECNOLOGICO DE BIZKAIA EDIFICIO 800 2A PLANTA city: DERIO postcode: 48160 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (DERIO)	coordinator	2˙516˙593.00
2	CENTRE FOR PROCESS INNOVATION LIMITED LBG CENTRE FOR PROCESS INNOVATION LIMITED LBG Organization address address: WILTON CENTRE WILTON city: REDCAR CLEVELAND postcode: TS10 4RF website: www.uk-cpi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (REDCAR CLEVELAND)	participant	2˙080˙420.00
3	MIDATECH LTD MIDATECH LTD Organization address address: ODDFELLOWS HOUSE 19 NEWPORT ROAD city: CARDIFF postcode: CF24 0AA website: www.midatechgroup.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CARDIFF)	participant	866˙958.00
4	GALCHIMIA SA GALCHIMIA SA Organization address address: LUGAR DE CEBREIRO SN city: O PINO A CORUNA postcode: 15823 website: www.galchimia.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (O PINO A CORUNA)	participant	675˙553.00
5	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	612˙921.00
6	PROCHIMIA SURFACES SP. Z O.O. PROCHIMIA SURFACES SP. Z O.O. Organization address address: ZACISZE 2 city: SOPOT postcode: 81823 website: www.prochimia.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (SOPOT)	participant	472˙875.00
7	LGAI TECHNOLOGICAL CENTER SA LGAI TECHNOLOGICAL CENTER SA Organization address address: RONDA DE LA FONT DEL CARME SN BELLATERRA CAMPUS DE LA UNIVERSITAT AUTONOMA DE BARCELONA city: CERDANYOLA DEL VALLES BARCELONA postcode: 8193 website: www.applus.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (CERDANYOLA DEL VALLES BARCELONA)	participant	409˙708.00
8	"INSTITUTO TUMORI ""GIOVANNI PAOLO II""" "INSTITUTO TUMORI ""GIOVANNI PAOLO II""" Organization address address: VIA ORAZIO FLACCO 65 city: BARI postcode: 70126 website: www.oncologico.bari.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BARI)	participant	187˙131.00
9	IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE Organization address address: VIA ADAMELLO 16 city: MILANO postcode: 20139 website: www.ifom-firc.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	76˙618.00
10	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00

Map

Project objective

A number of nanomedicine formulations have enabled, or been shown to hold considerable potential for enabling more effective and less toxic therapeutic interventions. However, progress to date in translating these initiatives to commercial success has been limited. One of the main reasons for this bottleneck is due to the inability of researchers and stakeholders to manufacture batches of the nanomedicine product at the required scale and according to Good Manufacturing Practice (GMP) requirements. The NANOFACTURING project will focus on - facilitating access to required infrastructures and expertise - creating GMP pilot lines for up-scaling manufacturing - addressing the current developmental and production gaps - taking nanomaterials already successfully produced at proof-of-concept/milligram levels and facilitating their scale-up to sub-kilogram quantities - providing large-scale and GMP production for clinical trials and nanomedicine translation. The NANOFACTURING project, through a consortium of 9 partners, will develop the synthetic processes, process control methods, analytical assays for QA/QC, functional specifications, and best practices, interfacing existing R&D centres of excellence, transfer organisations and private GMP manufacturing facilities (including SMEs) to ensure efficient translation from discovery through to first in man, proof-of-concept studies and beyond to Phase III according to industrial and regulatory standards. Specifically, the NANOFACTURING project aims to create a platform process for early, mid- and large-scale manufacturing of glycan-coated gold nanoparticles (GNPs), a widely researched and developed class of self-forming nanoparticles. The ability to engineer new nanopharmaceuticals based on this patent protected platform technology, developed by Midatech Biogune S.L. (Project Coordinator), will have inherent advantages over existing treatments for multiple therapeutic areas.

Deliverables

List of deliverables.
Final project report	Documents, reports	2019-11-22 17:48:27
Updated dissemination and exploitation plan	Documents, reports	2019-11-22 17:48:26
NANOFACTURING logo, brochure and leaflets	Documents, reports	2019-11-22 17:48:26
Launch of NANOFACTURING Website	Websites, patent fillings, videos etc.	2019-11-22 17:48:26
Outline dissemination plan	Documents, reports	2019-11-22 17:48:26

Take a look to the deliverables list in detail: detailed list of NANOFACTURING deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	V. Castagnola, W. Zhao, L. Boselli, M. C. Lo Giudice, F. Meder, E. Polo, K. R. Paton, C. Backes, J. N. Coleman, K. A. Dawson Biological recognition of graphene nanoflakes published pages: 1577 (2018), ISSN: 2041-1723, DOI: 10.1038/s41467-018-04009-x	Nature Communications 9/1	2019-11-22
2017	Laura Talamini, Martina B. Violatto, Qi Cai, Marco P. Monopoli, Karsten Kantner, Å½eljka KrpetiÄ‡, AndrÃ© Perez-Potti, Jennifer Cookman, David Garry, Camila P. Silveira, Luca Boselli, Beatriz Pelaz, Tommaso Serchi, SÃ©bastien Cambier, Arno C. Gutleb, Neus Feliu, Yan Yan, Mario Salmona, Wolfgang J. Parak, Kenneth A. Dawson, Paolo Bigini Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles published pages: 5519-5529, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b00497	ACS Nano 11/6	2019-11-22
2019	Fatima Alnasser, Valentina Castagnola, Luca Boselli, Margarita Esquivel-Gaon, Esen Efeoglu, Jennifer McIntyre, Hugh J. Byrne, Kenneth A. Dawson Graphene Nanoflake Uptake Mediated by Scavenger Receptors published pages: 1260-1268, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b04820	Nano Letters 19/2	2019-11-22
2017	Luca Boselli, Ester Polo, Valentina Castagnola, Kenneth A. Dawson Regimes of Biomolecular Ultrasmall Nanoparticle Interactions published pages: 4279-4282, ISSN: 0044-8249, DOI: 10.1002/ange.201700343	Angewandte Chemie 129/15	2019-11-22
2017	V. Castagnola, J. Cookman, J. M. de AraÃºjo, E. Polo, Q. Cai, C. P. Silveira, Å½. KrpetiÄ‡, Y. Yan, L. Boselli, K. A. Dawson Towards a classification strategy for complex nanostructures published pages: 187-198, ISSN: 2055-6756, DOI: 10.1039/C6NH00219F	Nanoscale Horizons 2/4	2019-11-22
2017	Riccardo Balzaretti, Fabian Meder, Marco P. Monopoli, Luca Boselli, Ilaria Armenia, Loredano Pollegioni, Giovanni Bernardini, Rosalba Gornati Synthesis, characterization and programmable toxicity of iron oxide nanoparticles conjugated with d -amino acid oxidase published pages: 1439-1442, ISSN: 2046-2069, DOI: 10.1039/c6ra25349k	RSC Advances 7/3	2019-11-22
2017	Zhi Luo, Jing Hou, Laure Menin, Quy Khac Ong, Francesco Stellacci Evolution of the Ligand Shell Morphology during Ligand Exchange Reactions on Gold Nanoparticles published pages: 13521-13525, ISSN: 1433-7851, DOI: 10.1002/anie.201708190	Angewandte Chemie International Edition 56/43	2019-11-22
2017	Quy Ong, Zhi Luo, Francesco Stellacci Characterization of Ligand Shell for Mixed-Ligand Coated Gold Nanoparticles published pages: 1911-1919, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.7b00165	Accounts of Chemical Research 50/8	2019-11-22
2016	Ahmet Bekdemir, Francesco Stellacci A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles published pages: , ISSN: 2041-1723, DOI: 10.1038/ncomms13121	Nature Communications 7/1	2019-11-22
2016	Kristof Zarschler, Louise Rocks, Nadia Licciardello, Luca Boselli, Ester Polo, Karina Pombo Garcia, Luisa De Cola, Holger Stephan, Kenneth A. Dawson Ultrasmall inorganic nanoparticles: State-of-the-art and perspectives for biomedical applications published pages: 1663-1701, ISSN: 1549-9634, DOI: 10.1016/j.nano.2016.02.019	Nanomedicine: Nanotechnology, Biology and Medicine 12/6	2019-11-22

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