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SpoKiGen SIGNED

Spore killer genomics: elucidating causes and consequences of a fungal meiotic drive element

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SpoKiGen project word cloud

Explore the words cloud of the SpoKiGen project. It provides you a very rough idea of what is the project "SpoKiGen" about.

introduce foundation profoundly preliminary hierarchy tool accepted acting evolutionary antagonistically force alternative speciation killer basic largely lacking killing transitions distorters hence view successful nevertheless genetic evolution decades driving conflicting eukaryote fungus primary analyze history meiotic sexual segregation significance genomic insights data fundamental network parts intrinsically gene found innovation pioneering emerged coevolve drive model caused presented neurospora mating spore empirical individual suggests plan drivers biological association coordinated genome cytological levels manifest biology conceptually selfish encoding unravel natural strength kit driver containing multitudinal experimental conflicts

Project "SpoKiGen" data sheet

The following table provides information about the project.

Coordinator	UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://www.iob.uu.se/research/systematic-biology/johannesson/research-areas/
Total cost	2˙000˙000 €
EC max contribution	2˙000˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	coordinator	2˙000˙000.00

Map

Project objective

The traditional view of the genome is that of a highly coordinated network that has evolved to produce a successful individual. However, the alternative view of the genome as containing intrinsically conflicting parts that coevolve antagonistically, has recently emerged. Today, it is widely accepted that conflicts caused by selfish genetic elements is a driving force for evolutionary innovation, and hence, is of fundamental importance for all aspects of evolution. Nevertheless, empirical data on the topic is largely lacking. Here, I introduce the fungus Neurospora as a novel study system of the evolutionary significance of meiotic drive. In this sexual eukaryote model system, the meiotic drive element Spore killer is found. The cytological properties and natural distribution of Spore killing in Neurospora has been investigated for several decades, and preliminary data suggests that it is an important driver of both genome evolution and of higher-order evolutionary processes. The existing knowledge and resources of this system provide a foundation for the proposed research program, in which I plan to build a tool-kit of genomic and experimental resources to I) identify and characterize the gene(s) encoding Spore killer elements, II) assess the strength of Spore killer as a meiotic drive, III) unravel the evolutionary history of the Spore killer complex in Neurospora, IV) investigate the association between Spore killer and genome evolution, and V) analyze the role of Spore killer as a driver of speciation and mating system transitions. This research program will manifest the Spore killer as a primary and pioneering model for the study of meiotic drive, and profoundly impact our understanding of segregation distorters as drivers of eukaryote genome evolution. Furthermore, insights emerging from the project presented are conceptually important for basic evolutionary biology, in the study of natural selection acting at multitudinal levels in a biological hierarchy.

Publications

List of publications.
year	authors and title	journal	last update
2017	Jesper Svedberg Catching the Spore killers. Genomic conflict and genome evolution in Neurospora. published pages: , ISSN: , DOI:		2019-06-06
2017	Yu Sun, Jesper Svedberg, Markus Hiltunen, PÃ¡draic Corcoran, Hanna Johannesson Large-scale suppression of recombination predates genomic rearrangements in Neurospora tetrasperma published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01317-6	Nature Communications 8/1	2019-06-06

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