NLRs
Mechanisms of natural auto immunity triggered by plant NLR immune receptors
Total Cost €
0EC-Contrib. €
0Partnership
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0NLRs project word cloud
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Project "NLRs" data sheet
The following table provides information about the project.
| Coordinator |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | http://www.weigelworld.org/research/hybrid-performance-and-immunity.html |
| Total cost | 159˙460 € |
| EC max contribution | 159˙460 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2017-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV | DE (MUENCHEN) | coordinator | 159˙460.00 |
Map
Project objective
Resistance (R) loci with nucleotide binding/leucine rich repeat (NB-LRR or NLR) domains have been identified as the major causal genes for hybrid necrosis, which presents an extreme example of the trade-off between plant growth and the activation of immune system. This is an exciting finding both for plant breeders and plant pathologists. However, how these NLR proteins or even the whole NLR family lead to hybrid necrosis, how they contribute to fitness under natural conditions, and how this is reflected in their extreme sequence variation remain largely unknown. In this proposal, I plan to exhaustively explore their function by systematically knocking out the NLR loci from genome of different Arabidopsis accessions using genome editing, and testing their fitness performance in the natural habitat. I will also reveal the cellular and biochemical mechanisms by which NLR proteins inappropriately interact with other cellular proteins to cause hybrid necrosis and compare the hybrid necrosis activity with pathogen induced immunity.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Xiuli Bi, Ying-Juan Cheng, Bo Hu, Xiaoli Ma, Rui Wu, Jia-Wei Wang, Chang Liu Nonrandom domain organization of the Arabidopsis genome at the nuclear periphery published pages: 1162-1173, ISSN: 1088-9051, DOI: 10.1101/gr.215186.116 |
Genome Research 27/7 | 2019-07-23 |
| 2017 |
Giovanna Capovilla, Efthymia Symeonidi, Rui Wu, Markus Schmid Contribution of major FLM isoforms to temperature-dependent flowering in Arabidopsis thaliana published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/erx328 |
Journal of Experimental Botany | 2019-07-23 |
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