ASSIMILES SIGNED
Advanced Spectroscopy and Spectrometry for Imaging Metabolism using Isotopically-Labeled Endogenous Substrates
Total Cost €
0EC-Contrib. €
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Project "ASSIMILES" data sheet
The following table provides information about the project.
| Coordinator |
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | https://crukcambridgecentre.org.uk/users/arnaud-comment |
| Total cost | 2˙199˙145 € |
| EC max contribution | 2˙199˙145 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2021-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE | UK (CAMBRIDGE) | coordinator | 2˙199˙145.00 |
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Project objective
A technological revolution is currently taking place making it possible to noninvasively study metabolism in mammals (incl. humans) in vivo with unprecedented temporal and spatial resolution. Central to these developments is the phenomenon of hyperpolarization, which transiently enhances the magnetic resonance (MR) signals so much that real-time metabolic imaging and spectroscopy becomes possible. The first clinical translation of hyperpolarization MR technology has recently been demonstrated with prostate cancer patients. I have played an active role in these exciting developments, through design and construction of hyperpolarization MR setups that are defining the cutting-edge for in vivo preclinical metabolic studies. However, important obstacles still exist for the technology to fulfill its enormous potential. With this highly interdisciplinary proposal, I will overcome the principal drawbacks of current hyperpolarization technology, namely: 1) A limited time window for hyperpolarized MR detection; 2) The conventional use of potentially toxic polarizing agents; 3) The necessity to use supra-physiological doses of metabolic substrates to reach detectable MR signal I will develop a novel hyperpolarization instrument making use of photoexcited compounds as polarizing agents to produce hyperpolarized solutions containing exclusively endogenous compounds. It will become possible to deliver hyperpolarized solutions in a quasi-continuous manner, permitting infusion of physiological doses and greatly increasing sensitivity. I will also use a complementary isotope imaging technique, the so-called CryoNanoSIMS (developed at my institution over the last year), which can image isotopic distributions in frozen tissue sections and reveal the localization of injected substrates and their metabolites with subcellular spatial resolution. Case studies will include liver and brain cancer mouse models. This work is pioneering and will create a new frontier in molecular imaging.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Yuhei Takado, Tian Cheng, Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Bernard Lanz, Mor Mishkovsky, Sylvain Lengacher, Arnaud Comment Hyperpolarized 13 C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood–Brain Barrier in the Cerebral Uptake and Metabolism of l -Lactate in Vivo published pages: 2554-2562, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00066 |
ACS Chemical Neuroscience 9/11 | 2020-01-22 |
| 2018 |
Irene Marco-Rius, Tian Cheng, Adam P. Gaunt, Saket Patel, Felix Kreis, Andrea Capozzi, Alan J. Wright, Kevin M. Brindle, Olivier Ouari, Arnaud Comment Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13 C MR with Photosensitive Metabolic Substrates published pages: 14455-14463, ISSN: 0002-7863, DOI: 10.1021/jacs.8b09326 |
Journal of the American Chemical Society 140/43 | 2020-01-22 |
| 2018 |
Irene Marcoâ€Rius and Arnaud Comment In Vivo Hyperpolarized 13C MRS and MRI Applications published pages: 167-177, ISSN: , DOI: |
eMagRes Volume 7 | 2020-01-22 |
| 2018 |
Jessica A. M. Bastiaansen, Hikari A. I. Yoshihara, Andrea Capozzi, Juerg Schwitter, Rolf Gruetter, Matthew E. Merritt, Arnaud Comment Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo-induced nonpersistent radicals published pages: 2451-2459, ISSN: 0740-3194, DOI: 10.1002/mrm.27122 |
Magnetic Resonance in Medicine 79/5 | 2020-01-22 |
| 2019 |
Andrea Capozzi, Saket Patel, Christine Pepke Gunnarsson, Irene Marco-Rius, Arnaud Comment, Magnus Karlsson, Mathilde H. Lerche, Olivier Ouari, Jan Henrik Ardenkjaer-Larsen Efficient Hyperpolarization of U- 13 C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals published pages: 1334-1339, ISSN: 1433-7851, DOI: 10.1002/anie.201810522 |
Angewandte Chemie International Edition 58/5 | 2020-01-22 |
| 2017 |
Andrea Capozzi, Tian Cheng, Giovanni Boero, Christophe Roussel, Arnaud Comment Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates published pages: 15757, ISSN: 2041-1723, DOI: 10.1038/ncomms15757 |
Nature Communications 8 | 2020-01-22 |
| 2017 |
Mor Mishkovsky, Brian Anderson, Magnus Karlsson, Mathilde H. Lerche, A. Dean Sherry, Rolf Gruetter, Zoltan Kovacs, Arnaud Comment Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized 13C magnetic resonance published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12086-z |
Scientific Reports 7/1 | 2020-01-22 |
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