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LARP4MOT

Structural and functional studies of LARP4, a new RNA binding protein involved in mRNA stabilisation and cell migration

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LARP4MOT project word cloud

Explore the words cloud of the LARP4MOT project. It provides you a very rough idea of what is the project "LARP4MOT" about.

concerted morphology biochemistry pabp regulation mechanisms screen excellent impacts disease biology turnover decay structural levels models rnai localisation polya central cell splicing intriguingly regulates act larp4 diseases rna binding health little binds chronic protein contributes mrna coordinated regulator rbps efficiency discovered invasion prostate polyadenylation translational molecular multiple aberrant stability human context atherosclerosis biophysics cellular cancer regulate gene lines rbp multidisciplinary understand translation migration precise expression inflammation combining proteins uncovered

Project "LARP4MOT" data sheet

The following table provides information about the project.

Coordinator	KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.kcl.ac.uk/lsm/research/divisions/randall/research/sections/structural/conte/index.aspx
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-09-01 to 2018-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

RNA-binding proteins (RBPs) act at multiple levels to regulate gene expression, including mRNA splicing, polyadenylation, localisation, stability, decay and translational efficiency and, although central to health and disease, much of this precise concerted regulation remains to be uncovered. The recently discovered LARP4 is an RBP that affects mRNA stability and binds to polyA as well as the polyA-binding protein (PABP). Intriguingly, LARP4 has recently been identified as a regulator of cell morphology and migration in an RNAi screen, but little is known about how control of gene expression at the translational level is coordinated during cell migration and invasion. Since aberrant cell migration contributes to the development of human diseases including cancer, chronic inflammation and atherosclerosis, LARP4 represents an excellent RBP to advance our understanding of key cellular mechanisms relating to mRNA processing and turnover. The overall aim of the project is to understand at a molecular level how LARP4 regulates mRNA translation and how this impacts on cell migration, especially in the context of cancer cell biology, using human prostate cancer cell lines as models. For this, a multidisciplinary approach combining biochemistry, biophysics, structural and cell biology will be used.

Publications

List of publications.
year	authors and title	journal	last update
2017	Richard J. Maraia, Sandy Mattijssen, Isabel Cruz-Gallardo, Maria R. Conte The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives published pages: e1430, ISSN: 1757-7004, DOI: 10.1002/wrna.1430	Wiley Interdisciplinary Reviews: RNA 8/6	2019-04-18
2019	Isabel Cruz-Gallardo, Luigi Martino, Roberta Trotta, Stefano De Tito, Geoff Kelly, R. Andrew Atkinson, Antonio Randazzo, Maria R. Conte Resonance assignment of human LARP4A La module published pages: , ISSN: 1874-2718, DOI: 10.1007/s12104-019-09871-4	Biomolecular NMR Assignments	2019-02-27
2019	Isabel Cruz-Gallardo, Luigi Martino, Geoff Kelly, RÂ Andrew Atkinson, Roberta Trotta, Stefano DeÂ Tito, Pierre Coleman, Zainab Ahdash, Yifei Gu, Tam T T Bui, Maria R Conte LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA published pages: 4272-4291, ISSN: 0305-1048, DOI: 10.1093/nar/gkz144	Nucleic Acids Research 47/8	2019-09-13

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