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TANYFEEDNEURONS

Gliotransmission and shuttling of metabolic signals to feeding neuronal circuits by tanycytes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TANYFEEDNEURONS project word cloud

Explore the words cloud of the TANYFEEDNEURONS project. It provides you a very rough idea of what is the project "TANYFEEDNEURONS" about.

leptin    techniques    food    anorexigenic    context    metabolic    transport    age    answering    physiological    tanycytes    mechanisms    direct    intake    electrophysiological    homeostasis    captured    electrical    adenosine    series    cellular    glia    roles    specialized    acute    genetic    slices    questions    obesity    diseases    experiments    blood    extracellular    disorders    nucleus    energy    tanyfeedneurons    atp    tools    interact    peptide    death    therapeutic    potentially    sense    neuron    intercellular    arh    lactate    redistribute    indicate    purinergic    neuronal    messenger    influence    fluid    release    triphosphate    mouse    little    modulate    parenchyma    interface    network    functional    status    selective    cerebrospinal    newly    designed    therapy    hypothalamus    cells    presented    arcuate    metabolite    located    hypothalamic    brain    treating    borne    signaling    csf    communication    tanycyte    neurons    critical    insights    glial    additionally    glucose    strategies    manipulations   

Project "TANYFEEDNEURONS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://hypothalamus.eu/fr/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Tanycytes are specialized hypothalamic glial cells located at the interface between blood, cerebrospinal fluid (CSF) and brain areas that control food intake. Little is known about their physiological roles. Recent studies indicate that tanycytes sense the extracellular glucose, release the intercellular messenger adenosine triphosphate (ATP) and the energy metabolite lactate, both of which can potentially modulate neuronal activity. Tanycytes also transport the blood-borne anorexigenic peptide leptin from the blood to the CSF and brain parenchyma. Understanding how this glia may be able to interact with neurons from the arcuate nucleus of the hypothalamus (ARH) that control food intake is critical to identify new cellular targets for the development of therapeutic strategies for treating metabolic disorders. Therefore, the series of experiments presented in the proposal are designed to determine how tanycytes may influence electrical activity of ARH neurons. More specifically, the project is based on answering the following questions: i) Does purinergic signaling in tanycytes modulate activity of ARH neurons? ii) Do tanycytes interact with ARH neurons through a metabolic network? iii) How do tanycytes redistribute captured leptin towards ARH neurons? Towards this end, I will use electrophysiological techniques in acute mouse brain slices and newly-developed genetic tools that allow selective manipulations of tanycyte signaling. Additionally, I propose to investigate how changes in metabolic status (e.g. obesity) may influence tanycyte-ARH neuron communication, providing new insights into functional mechanisms contributing to metabolic disorders. The TANYFEEDNEURONS project will provide direct evidence for tanycyte-neuron communication in the context of energy homeostasis and will identify tanycytes as potential therapy for metabolic disorders, which are age-related diseases and lead cause of death in Europe.

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