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TANYFEEDNEURONS

Gliotransmission and shuttling of metabolic signals to feeding neuronal circuits by tanycytes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TANYFEEDNEURONS project word cloud

Explore the words cloud of the TANYFEEDNEURONS project. It provides you a very rough idea of what is the project "TANYFEEDNEURONS" about.

electrophysiological    selective    glia    death    hypothalamic    specialized    designed    therapeutic    captured    brain    electrical    metabolite    glial    obesity    genetic    diseases    disorders    triphosphate    age    answering    tanyfeedneurons    questions    strategies    energy    functional    cerebrospinal    tools    release    neurons    insights    neuronal    intercellular    little    potentially    manipulations    transport    redistribute    additionally    arh    communication    signaling    physiological    csf    tanycytes    interface    influence    newly    context    mouse    series    arcuate    leptin    located    presented    sense    fluid    parenchyma    cellular    lactate    food    glucose    status    indicate    peptide    nucleus    slices    intake    neuron    atp    experiments    therapy    treating    cells    adenosine    blood    techniques    purinergic    network    homeostasis    anorexigenic    messenger    acute    modulate    interact    direct    extracellular    borne    mechanisms    hypothalamus    critical    tanycyte    roles    metabolic   

Project "TANYFEEDNEURONS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://hypothalamus.eu/fr/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Tanycytes are specialized hypothalamic glial cells located at the interface between blood, cerebrospinal fluid (CSF) and brain areas that control food intake. Little is known about their physiological roles. Recent studies indicate that tanycytes sense the extracellular glucose, release the intercellular messenger adenosine triphosphate (ATP) and the energy metabolite lactate, both of which can potentially modulate neuronal activity. Tanycytes also transport the blood-borne anorexigenic peptide leptin from the blood to the CSF and brain parenchyma. Understanding how this glia may be able to interact with neurons from the arcuate nucleus of the hypothalamus (ARH) that control food intake is critical to identify new cellular targets for the development of therapeutic strategies for treating metabolic disorders. Therefore, the series of experiments presented in the proposal are designed to determine how tanycytes may influence electrical activity of ARH neurons. More specifically, the project is based on answering the following questions: i) Does purinergic signaling in tanycytes modulate activity of ARH neurons? ii) Do tanycytes interact with ARH neurons through a metabolic network? iii) How do tanycytes redistribute captured leptin towards ARH neurons? Towards this end, I will use electrophysiological techniques in acute mouse brain slices and newly-developed genetic tools that allow selective manipulations of tanycyte signaling. Additionally, I propose to investigate how changes in metabolic status (e.g. obesity) may influence tanycyte-ARH neuron communication, providing new insights into functional mechanisms contributing to metabolic disorders. The TANYFEEDNEURONS project will provide direct evidence for tanycyte-neuron communication in the context of energy homeostasis and will identify tanycytes as potential therapy for metabolic disorders, which are age-related diseases and lead cause of death in Europe.

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