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ChloroQuality

Dissecting chloroplast protein quality control specificity for rational plant reprogramming

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ChloroQuality project word cloud

Explore the words cloud of the ChloroQuality project. It provides you a very rough idea of what is the project "ChloroQuality" about.

proteins    little    substrates    organisms    lack    discovering    scientist    synergistically    regulated    heat    constitute    demand    survival    undesirable    biology    receiving    cope    quality    stresses    enzymes    environmental    demands    ing    chloroplastic    background    recycling    levels    losses    adverse    flexible    society    chloroplast    toxic    determined    strategies    specificity    interactors    photosynthesis    stress    expertise    refolding    recognize    damage    crop    fundamental    transfer    unfolded    protein    metabolism    candidate    rational    validating    sessile    plant    act    chaperone    death    alter    aggregated    plants    network    signaling    economy    hsp70    independent    posttranslationally    coordinately    productivity    engineering    molecular    food    cover    line    damaged    transgenic    shed    light    improvement    adaptors    regulate    resistance    improving    group    chloroplasts    salt    drought    misfolding    fitness    cold    action    investigation    proteases    degraded    aggregation    cellular    chaperones    gap   

Project "ChloroQuality" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://plantmolecularbiology.bio.lmu.de/research/plant-acclimation/chloroplast-protein/index.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

Improving food quality, crop productivity and plant resistance to stresses are major demands of Europe’s society and economy. Plants are sessile organisms that have developed very flexible strategies to cope with adverse environmental conditions as heat, cold, drought and salt stress. These stresses cause protein misfolding and aggregation resulting in plant damage/death and productivity losses. Recycling of damaged proteins is achieved by the action of molecular chaperones. But when recycling is not possible, toxic aggregated proteins have to be degraded by the action of proteases to avoid cellular damage. Chaperones and proteases act coordinately and constitute the protein quality control system that is essential for plant survival. In plant chloroplasts, the chaperone Hsp70 is known to posttranslationally regulate important processes like photosynthesis. It is known that the specificity of Hsp70 is determined by its J-protein partners, adaptors that recognize unfolded substrates and transfer them to the chaperone for refolding. However, little is known about the target proteins of Hsp70, such that there is a large lack of information about how chloroplastic enzymes are regulated at protein levels. This knowledge is crucial for rational engineering of specific molecular pathways and plant fitness improvement. The ability to specifically alter plant metabolism without undesirable effects is a fundamental demand of European society and addresses current concerns about transgenic plants. This proposal aims to cover this gap by discovering and validating interactors of chloroplastic J-proteins. The strong background of the applicant in protein quality control and the expertise in chloroplast biology of the receiving group will synergistically contribute to shed light on the chloroplast signaling network. In addition, this project aims to develop the candidate into an independent scientist and open his own line of investigation.

 Publications

year authors and title journal last update
List of publications.
2017 Nicola Zagari, Omar Sandoval-Ibañez, Niels Sandal, Junyi Su, Manuel Rodriguez-Concepcion, Jens Stougaard, Mathias Pribil, Dario Leister, Pablo Pulido
SNOWY COTYLEDON 2 Promotes Chloroplast Development and Has a Role in Leaf Variegation in Both Lotus japonicus and Arabidopsis thaliana
published pages: 721-734, ISSN: 1674-2052, DOI: 10.1016/j.molp.2017.02.009
Molecular Plant 10/5 2019-06-13
2018 Pablo Pulido, Dario Leister
Novel DNAJ-related proteins in Arabidopsis thaliana
published pages: 480-490, ISSN: 0028-646X, DOI: 10.1111/nph.14827
New Phytologist 217/2 2019-06-13

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