Opendata, web and dolomites

SUGARCODING SIGNED

The neuroenergetics of memory consolidation – hybrid PET/MR imaging of the default mode network

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SUGARCODING project word cloud

Explore the words cloud of the SUGARCODING project. It provides you a very rough idea of what is the project "SUGARCODING" about.

interrupted    mind    orchestrate    anxiety    invasive    connectivity    emission    function    imaging    mr    retrieval    ago    plasticity    paradox    deactivations    deactivates    once    uncovering    complementary    hybrid    functional    integrating    deviations    episodic    pet    tomography    subjects    memories    sugarcoding    stimulation    revealed    option    baseline    psychiatric    glucose    disease    resemble    disorders    alzheimer    directional    neuronal    discovery    since    fmri    regions    resonance    simultaneously    consumes    massively    encoding    pathological    signaling    resting    track    mode    hypothesize    human    energy    network    default    metabolic    reported    directed    unknown    hundreds    brain    disturbed    decade    consolidated    memory    critically    hypothesis    active    first    demand    dmn    synaptic    metabolism    therapeutic    mainly    magnetic    engage    seems    modulate    cognitive    behavior    affective    universal    positron    consolidation   

Project "SUGARCODING" data sheet

The following table provides information about the project.

Coordinator
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN 

Organization address
address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675
website: http://www.med.tu.muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙403 €
 EC max contribution 1˙499˙403 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE (MUENCHEN) coordinator 1˙499˙403.00

Map

 Project objective

Since its discovery more than a decade ago, the most studied network in the human brain remains a paradox. The default mode network (DMN) is most active during the resting state and deactivates once subjects engage in goal directed behavior. Although reported in hundreds of studies using functional magnetic resonance imaging (fMRI), the function of the DMN is still unknown. I hypothesize that memories are consolidated in the DMN during resting state, a process that is interrupted once we engage in cognitive processing. This hypothesis is based on two complementary and recent findings. First, brain regions involved in encoding of novel or retrieval of consolidated memories strongly resemble regions of the DMN. Second, the DMN consumes most glucose during resting state as revealed by positron emission tomography (PET). Importantly, energy in the brain is mainly dedicated to neuronal signaling and synaptic plasticity related to memory consolidation. To test my hypothesis, I will use hybrid PET/MR imaging to simultaneously study fMRI activity and energy metabolism of the DMN during episodic memory processing. Integrating this novel imaging approach with my recently developed brain connectivity methods, I will (i) identify the metabolic baseline of fMRI-deactivations in the DMN, (ii) track the metabolic demand and directional connectivity in the DMN during memory consolidation, and (iii) evaluate non-invasive brain stimulation as a therapeutic option to modulate memory consolidation. The DMN is massively disturbed in psychiatric disorders such as Alzheimer’s disease, anxiety and affective disorders. SUGARCODING aims at uncovering memory consolidation as a universal function of the DMN that seems to critically orchestrate the human mind and its pathological deviations. ...

 Publications

year authors and title journal last update
List of publications.
2020 Gabriel Castrillon, Nico Sollmann, Katarzyna Kurcyus, Adeel Razi, Sandro M. Krieg, Valentin Riedl
The physiological effects of noninvasive brain stimulation fundamentally differ across the human cortex
published pages: eaay2739, ISSN: 2375-2548, DOI: 10.1126/sciadv.aay2739
Science Advances 6/5 2020-03-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SUGARCODING" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SUGARCODING" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KineTic (2020)

New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Read More  

NEUTRAMENTH (2018)

A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol

Read More  

E-DURA (2018)

Commercialization of novel soft neural interfaces

Read More