Opendata, web and dolomites

HAT-MOZ-sphere

Identification of genes and pathways regulated by the HAT activity of MOZ

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 HAT-MOZ-sphere project word cloud

Explore the words cloud of the HAT-MOZ-sphere project. It provides you a very rough idea of what is the project "HAT-MOZ-sphere" about.

acetyl    technique    translocations    crucially    comprise    fusion    multidisciplinary    cancer    marrow    dr    variety    bone    immunoprecipitation    cells    histone    transferase    zinc    haematopoietic    abrogate    performed    silac    polymerase    loci    retrovirus    myeloblastic    moz    largeot    haematopoiesis    institute    expertise    seq    regulated    uk    murine    tif2    marks    transferable    training    genes    function    calibre    proteins    manchester    skills    survey    acute    chromatin    epigenetic    modifications    player    maintenance    finger    sequencing    anne    powerful    obtain    tool    model    position    line    recruitment    determined    encoding    followed    enzymatic    hat    landscape    mouse    monocytic    genome    deletion    chip    rna    supervisor    relying    laboratory    competitive    leukaemic    exceptionally    obtaining    critical    host    leadership    mutated    understand    leukaemia    transduction    programs    leukaemogenesis    protein   

Project "HAT-MOZ-sphere" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.cruk.manchester.ac.uk/Research/CRUK-MI-Groups/Stem-Cell-Biology/Home
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 195˙454.00

Map

 Project objective

The research programme will comprise the study of the Histone acetyl transferase (HAT) MOZ (Monocytic leukaemia Zinc finger) a critical player in the development and maintenance of the haematopoietic system. In addition, translocations of MOZ are associated with Acute Myeloblastic Leukaemia. Given the importance of this protein in haematopoiesis and leukaemogenesis, it would be essential to further understand the function of MOZ and in particular to identify the genes regulated by its HAT activity of MOZ. A mouse line specifically mutated to abrogate the HAT enzymatic activity of MOZ has been developed in the host laboratory, and represents a powerful and unique tool for the study of MOZ HAT activity. Using Chromatin ImmunoPrecipitation followed by sequencing (ChIP-seq), genome wide targets of MOZ will be determined and the consequences of the deletion of its HAT activity on the epigenetic landscape will be investigated through the survey of several histone modifications and RNA polymerase II recruitment. The non-histone targets of MOZ will be identified through the SILAC technique. Finally a MOZ murine leukaemic model has been developed, based on the transduction of bone marrow cells with a retrovirus encoding MOZ-TIF2, one of the fusion proteins involving MOZ. ChIP-seq will be performed in these leukaemic cells to identify genes targeted by MOZ-TIF2 and changes in epigenetic marks at these loci. Overall, this project will provide a better understanding of MOZ HAT activity in haematopoiesis and leukaemogenesis. Crucially, this project will enable Dr Anne Largeot to obtain and develop a wide range of new and transferable skills through a variety of multidisciplinary training programs. Relying on the knowledge and expertise of her supervisor and the exceptionally high calibre of the Cancer Research UK Manchester Institute, this project will enable Dr Anne Largeot to achieve her long-term objective of obtaining a leadership position in a competitive European Institute

 Publications

year authors and title journal last update
List of publications.
2016 Andrew J. Lilly, Guilherme Costa, Anne Largeot, Muhammad Z. H. Fadlullah, Michael Lie-A-Ling, Georges Lacaud, Valerie Kouskoff
Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac
published pages: 4341-4351, ISSN: 0950-1991, DOI: 10.1242/dev.140970
Development 143/23 2019-06-14
2016 Anne Largeot, Flor Maria Perez-Campo, Elli Marinopoulou, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud
Expression of the MOZ-TIF2 oncoprotein in mice represses senescence
published pages: 231-237.e4, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2015.12.006
Experimental Hematology 44/4 2019-06-14

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HAT-MOZ-SPHERE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HAT-MOZ-SPHERE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

OSeaIce (2019)

Two-way interactions between ocean heat transport and Arctic sea ice

Read More  

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  

EcoSpy (2018)

Leveraging the potential of historical spy satellite photography for ecology and conservation

Read More