Opendata, web and dolomites

HAT-MOZ-sphere

Identification of genes and pathways regulated by the HAT activity of MOZ

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 HAT-MOZ-sphere project word cloud

Explore the words cloud of the HAT-MOZ-sphere project. It provides you a very rough idea of what is the project "HAT-MOZ-sphere" about.

multidisciplinary    model    haematopoietic    technique    line    cancer    chromatin    expertise    acute    marks    transferable    obtain    deletion    proteins    exceptionally    understand    enzymatic    epigenetic    powerful    crucially    maintenance    critical    comprise    transduction    silac    institute    encoding    mutated    tool    moz    abrogate    rna    leukaemic    zinc    murine    landscape    followed    determined    seq    marrow    laboratory    manchester    polymerase    host    haematopoiesis    monocytic    player    leukaemogenesis    chip    supervisor    acetyl    skills    transferase    programs    recruitment    regulated    performed    function    histone    immunoprecipitation    sequencing    mouse    largeot    translocations    hat    training    genes    dr    calibre    genome    anne    variety    retrovirus    leukaemia    obtaining    tif2    finger    uk    myeloblastic    fusion    competitive    protein    modifications    position    relying    leadership    loci    cells    bone    survey   

Project "HAT-MOZ-sphere" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.cruk.manchester.ac.uk/Research/CRUK-MI-Groups/Stem-Cell-Biology/Home
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 195˙454.00

Map

 Project objective

The research programme will comprise the study of the Histone acetyl transferase (HAT) MOZ (Monocytic leukaemia Zinc finger) a critical player in the development and maintenance of the haematopoietic system. In addition, translocations of MOZ are associated with Acute Myeloblastic Leukaemia. Given the importance of this protein in haematopoiesis and leukaemogenesis, it would be essential to further understand the function of MOZ and in particular to identify the genes regulated by its HAT activity of MOZ. A mouse line specifically mutated to abrogate the HAT enzymatic activity of MOZ has been developed in the host laboratory, and represents a powerful and unique tool for the study of MOZ HAT activity. Using Chromatin ImmunoPrecipitation followed by sequencing (ChIP-seq), genome wide targets of MOZ will be determined and the consequences of the deletion of its HAT activity on the epigenetic landscape will be investigated through the survey of several histone modifications and RNA polymerase II recruitment. The non-histone targets of MOZ will be identified through the SILAC technique. Finally a MOZ murine leukaemic model has been developed, based on the transduction of bone marrow cells with a retrovirus encoding MOZ-TIF2, one of the fusion proteins involving MOZ. ChIP-seq will be performed in these leukaemic cells to identify genes targeted by MOZ-TIF2 and changes in epigenetic marks at these loci. Overall, this project will provide a better understanding of MOZ HAT activity in haematopoiesis and leukaemogenesis. Crucially, this project will enable Dr Anne Largeot to obtain and develop a wide range of new and transferable skills through a variety of multidisciplinary training programs. Relying on the knowledge and expertise of her supervisor and the exceptionally high calibre of the Cancer Research UK Manchester Institute, this project will enable Dr Anne Largeot to achieve her long-term objective of obtaining a leadership position in a competitive European Institute

 Publications

year authors and title journal last update
List of publications.
2016 Andrew J. Lilly, Guilherme Costa, Anne Largeot, Muhammad Z. H. Fadlullah, Michael Lie-A-Ling, Georges Lacaud, Valerie Kouskoff
Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac
published pages: 4341-4351, ISSN: 0950-1991, DOI: 10.1242/dev.140970
Development 143/23 2019-06-14
2016 Anne Largeot, Flor Maria Perez-Campo, Elli Marinopoulou, Michael Lie-a-Ling, Valerie Kouskoff, Georges Lacaud
Expression of the MOZ-TIF2 oncoprotein in mice represses senescence
published pages: 231-237.e4, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2015.12.006
Experimental Hematology 44/4 2019-06-14

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HAT-MOZ-SPHERE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HAT-MOZ-SPHERE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EcoSpy (2018)

Leveraging the potential of historical spy satellite photography for ecology and conservation

Read More  

OSeaIce (2019)

Two-way interactions between ocean heat transport and Arctic sea ice

Read More  

LYSOKIN (2020)

Architecture and regulation of PI3KC2β lipid kinase complex for nutrient signaling at the lysosome

Read More