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GENOLACT

Consolidating a genomic framework for exploiting lactobacilli

Total Cost €

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EC-Contrib. €

0

Partnership

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 GENOLACT project word cloud

Explore the words cloud of the GENOLACT project. It provides you a very rough idea of what is the project "GENOLACT" about.

safety    bacteria    genes    genetic    academic    species    meeting    create    beneficial    industry    actual    characterization    chemical    manufacturers    moulded    difficulties    lack    genus    claim    safe    genomic    regulatory    transfer    approval    risk    guidelines    mechanisms    lactobacilli    market    link    acquisition    difficult    fermented    textile    claims    gene    live    companies    delineate    probiotics    probiotic    unravel    broad    despite    industrial    efficient    majority    ways    successful    underpin    dietary    perform    ambitions    conversion    environmentally    phenotypes    suitability    belong    strain    food    forensically    decay    preservatives    scientific    compliance    solutions    healthier    scientists    transferred    strains    lactobacillus    molecular    synthesis    proved    genome    health    validating    microorganisms    surge    deeper    chance    gras    placing    backbone    supplementary    proposals    proper    friendlier    data    history    lactate    efsa   

Project "GENOLACT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://apc.ucc.ie/
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 187˙866.00

Map

 Project objective

Probiotics are defined as live microorganisms with a long history of safe use and a robust evidence for providing beneficial effects to the consumer. The majority of probiotic bacteria belong to Lactobacillus genus, which includes a large number of GRAS species, essential in fermented food production and for use as food preservatives. Lactobacilli have also a range of non-food applications, such as industrial production of lactate for the textile industry in environmentally friendlier ways than chemical synthesis. Despite their broad use, health claims approval by EFSA for probiotics is challenging due to scientific difficulties in validating probiotic mechanisms and a lack of proper strain characterization. Although there has been a surge in research into probiotics, the conversion into actual claims and compliance with the regulatory requirements has proved difficult. The aim of the project is to perform forensically detailed comparative genomic analysis of Lactobacillus species to i) unravel the genetic backbone that has been moulded by genome decay and gene acquisition ii) delineate the genetic features and molecular mechanisms that underpin their health-promoting effects and suitability for use, and iii) identify genes associated with the phenotypes for new food applications. A deeper insight into the safety-related issues for food strains will provide a comprehensive assessment on risk factors to be transferred to companies as supplementary safety guidelines for successful health claim proposals. Data obtained will be used to develop new dietary solutions and safe non-food applications, thus increasing manufacturers’ interest in placing beneficial products on the market and meeting the consumer’s ambitions to live healthier. Within the project, the applicant will have the chance to perform high-level research with leading scientists and create a link between academic institutions and companies for efficient technology transfer and novel industrial solutions.

 Publications

year authors and title journal last update
List of publications.
2017 Elisa Salvetti, Paul W. O’Toole
The Genomic Basis of Lactobacilli as Health-Promoting Organisms
published pages: , ISSN: 2165-0497, DOI: 10.1128/microbiolspec.BAD-0011-2016
Microbiology Spectrum 5/3 2019-07-24
2017 Elisa Salvetti, Paul W. O\'Toole
When regulation challenges innovation: The case of the genus Lactobacillus
published pages: 187-194, ISSN: 0924-2244, DOI: 10.1016/j.tifs.2017.05.009
Trends in Food Science & Technology 66 2019-07-24

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