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CSDP

Construction of Self-Dividing Protocells

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CSDP project word cloud

Explore the words cloud of the CSDP project. It provides you a very rough idea of what is the project "CSDP" about.

cells platform incorporated biochemistry gene chemical believe prepare cell skills create liposomes multiple divisome droplets provides avenues extensive reaction microfluidics energy networks cellular expression construction aqueous monodisperse fundamental ring reconstituted examples radboud bacterial utilized functions self construct compartments revolutionary behavior biophysical synthetic chemistry deeper dividing preparation droplet ru generation mimic protocells natural replication biology combines materials principles expertise vitro valuable reconstitution picoliter biomimetic emulsions division university artificial obtain

Project "CSDP" data sheet

The following table provides information about the project.

Coordinator	STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.ru.nl/physicalorganicchemistry/
Total cost	177˙598 €
EC max contribution	177˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-08-01 to 2017-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	coordinator	177˙598.00

Map

Project objective

Artificial cells are synthetic compartments that are able to mimic one or more properties of natural cells and provide valuable avenues for the study of fundamental cellular functions. However, thus far there are no examples of synthetic systems/materials that can achieve self-replication. Therefore the key aim of this project is to create artificial self-dividing protocells. I will build a platform that combines synthetic chemistry, cell biology and microfluidics to prepare cell-like systems. Monodisperse picoliter multiple all-aqueous droplet systems (e.g., liposomes) generated by microfluidics will be utilized to construct self-dividing protocells. To achieve division, the so-called Z-ring of the bacterial divisome will be incorporated in droplets, together with an energy-generation system. I have extensive experience in microfluidics research and especially in the preparation of multiple emulsions with complex compartments, which I will exploit in this project. At Radboud University (RU), I will obtain new skills and expertise in biochemistry and biology such as in vitro gene expression, chemical reaction networks, and bottom-up synthetic biology. Importantly, the reconstitution of an artificial cell divisome would lead to a deeper understanding of the biophysical principles of cellular behavior and will be the most fundamental step towards construction of artificial cells. I believe this in vitro reconstituted system provides a revolutionary new platform for biomimetic research.

Publications

List of publications.
year	authors and title	journal	last update
2017	Fei Peng, Nan-Nan Deng, Yingfeng Tu, Jan C. M. van Hest, Daniela A. Wilson Continuous fabrication of polymeric vesicles and nanotubes with fluidic channels published pages: 4875-4880, ISSN: 2040-3364, DOI: 10.1039/C7NR00142H	Nanoscale 9/15	2019-06-18
2017	Nan-Nan Deng, Wilhelm T. S. Huck Microfluidic Formation of Monodisperse Coacervate Organelles in Liposomes published pages: 9736-9740, ISSN: 1433-7851, DOI: 10.1002/anie.201703145	Angewandte Chemie International Edition 56/33	2019-06-18
2016	Nan-Nan Deng, Maaruthy Yelleswarapu, Wilhelm T. S. Huck Monodisperse Uni- and Multicompartment Liposomes published pages: 7584-7591, ISSN: 0002-7863, DOI: 10.1021/jacs.6b02107	Journal of the American Chemical Society 138/24	2019-06-18
2017	Nan-Nan Deng, Maaruthy Yelleswarapu, Lifei Zheng, and Wilhelm T. S. Huck Microfluidic Assembly of Monodisperse Vesosomes as Artificial Cell Models published pages: 587-590, ISSN: 0002-7863, DOI: 10.1021/jacs.6b10977	Journal of the American Chemical Society 139/2	2019-06-18

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The information about "CSDP" are provided by the European Opendata Portal: CORDIS opendata.