POSEIDON TERMINATED
novel bioreactor Platform for reprOducible, Scalable ExpansIonand cardiac DifferentiatiON of hiPSC in suspension culture
Total Cost €
0EC-Contrib. €
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Project "POSEIDON" data sheet
The following table provides information about the project.
| Coordinator |
MEDIZINISCHE HOCHSCHULE HANNOVER
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | https://www.researchgate.net/project/Novel-bioreactor-platform-for-reproducible-scalable-expansion-and-cardiac-differentiation-of-hiPSC-in-suspension-culture-POSEIDON |
| Total cost | 159˙460 € |
| EC max contribution | 159˙460 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-10-01 to 2017-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | MEDIZINISCHE HOCHSCHULE HANNOVER | DE (HANNOVER) | coordinator | 159˙460.00 |
Map
Project objective
Human induced pluripotent stem cells (hiPSCs) have the potential to revolutionize biomedical sciences, however the standardised mass production, indispensable for their industrial and therapeutic use, is still a major challenge. Impeller stirred-tank bioreactors, currently used for hiPSC bioprocessing, impose detrimental stresses on cultured hiPSCs, resulting in heterogeneity of cells and cell-aggregates, limited bioprocess reproducibility, and low hiPSC expansion efficiency at high costs. The ambitious purpose of the POSEIDON project is the development of a next-generation automated bioreactor platform to significantly improve reproducibility, efficiency and cost-effectiveness of scalable hiPSC expansion. To demonstrate the utility of the method for the production of valuable human cell types, a novel process for hiPSC-cardiomyogenic differentiation will also be established. This pioneering bioreactor will be developed by advanced engineering design methods and will enable controlled hiPSC suspension culture by non-impeller-dependent low-shear hydrodynamic conditions. Purposely designed automated systems will lead to bioprocess standardisation with enhanced reproducibility, efficiency and scalability beyond the state in the art. The proposed Fellowship will enable a highly interdisciplinary collaboration between the Researcher, a talented post-doc with a significant track record in bioengineering, and the supervisor, a world leader in stem cell bioprocessing, whose group is embedded in one of Europe’s leading hubs for regenerative biomedicine. These working conditions will effectively promote the Researcher’s professional development, providing her with excellent new expertise in stem cell bioprocessing and fundamental leadership skills, significantly widening her career perspectives. The project outcomes will be of tremendous benefit to the European biomedical and pharmaceutical sectors, contributing to the European excellence, competitiveness and quality of life.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Diana Massai, Emiliano Bolesani, Diana Robles Diaz, Christina Kropp, Henning Kempf, Caroline Halloin, Ulrich Martin, Tudor Braniste, Giuseppe Isu, Vanessa Harms, Umberto Morbiducci, Gerald Dräger, Robert Zweigerdt Sensitivity of human pluripotent stem cells to insulin precipitation induced by peristaltic pump-based medium circulation: considerations on process development published pages: 1-15, ISSN: 2045-2322, DOI: 10.1038/s41598-017-04158-x |
Scientific Reports 7/1 | 2019-06-18 |
| 2017 |
Isotta Chimenti, Diana Massai, Umberto Morbiducci, Antonio Paolo Beltrami, Maurizio Pesce, Elisa Messina Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up published pages: 150-166, ISSN: 1937-5387, DOI: 10.1007/s12265-017-9741-5 |
Journal of Cardiovascular Translational Research 10/2 | 2019-06-18 |
| 2017 |
Christina Kropp, Diana Massai, Robert Zweigerdt Progress and challenges in large-scale expansion of human pluripotent stem cells published pages: 244-254, ISSN: 1359-5113, DOI: 10.1016/j.procbio.2016.09.032 |
Process Biochemistry 59 | 2019-06-18 |
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