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POSEIDON TERMINATED

novel bioreactor Platform for reprOducible, Scalable ExpansIonand cardiac DifferentiatiON of hiPSC in suspension culture

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 POSEIDON project word cloud

Explore the words cloud of the POSEIDON project. It provides you a very rough idea of what is the project "POSEIDON" about.

standardised    heterogeneity    mass    expansion    suspension    cultured    professional    stem    perspectives    benefit    industrial    skills    world    differentiation    talented    therapeutic    hipsc    efficiency    impose    pluripotent    expertise    supervisor    stresses    engineering    competitiveness    excellence    fellowship    utility    bioprocessing    bioreactor    hipscs    purposely    scalable    purpose    leadership    bioreactors    ing    effectiveness    shear    outcomes    scalability    enhanced    researcher    track    cells    biomedicine    excellent    sciences    hubs    significantly    post    tremendous    cell    aggregates    pioneering    group    dependent    pharmaceutical    culture    designed    hydrodynamic    standardisation    leader    bioengineering    human    bioprocess    life    cardiomyogenic    detrimental    doc    career    sectors    interdisciplinary    reproducibility    tank    revolutionize    fundamental    indispensable    impeller    valuable    platform    stirred    poseidon    automated    types    biomedical    regenerative    record    limited    quality    widening    generation   

Project "POSEIDON" data sheet

The following table provides information about the project.

Coordinator		 MEDIZINISCHE HOCHSCHULE HANNOVER 

Organization address
address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625
website: www.mh-hannover.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website https://www.researchgate.net/project/Novel-bioreactor-platform-for-reproducible-scalable-expansion-and-cardiac-differentiation-of-hiPSC-in-suspension-culture-POSEIDON
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE HOCHSCHULE HANNOVER DE (HANNOVER) coordinator 159˙460.00

Map

 Project objective

Human induced pluripotent stem cells (hiPSCs) have the potential to revolutionize biomedical sciences, however the standardised mass production, indispensable for their industrial and therapeutic use, is still a major challenge. Impeller stirred-tank bioreactors, currently used for hiPSC bioprocessing, impose detrimental stresses on cultured hiPSCs, resulting in heterogeneity of cells and cell-aggregates, limited bioprocess reproducibility, and low hiPSC expansion efficiency at high costs. The ambitious purpose of the POSEIDON project is the development of a next-generation automated bioreactor platform to significantly improve reproducibility, efficiency and cost-effectiveness of scalable hiPSC expansion. To demonstrate the utility of the method for the production of valuable human cell types, a novel process for hiPSC-cardiomyogenic differentiation will also be established. This pioneering bioreactor will be developed by advanced engineering design methods and will enable controlled hiPSC suspension culture by non-impeller-dependent low-shear hydrodynamic conditions. Purposely designed automated systems will lead to bioprocess standardisation with enhanced reproducibility, efficiency and scalability beyond the state in the art. The proposed Fellowship will enable a highly interdisciplinary collaboration between the Researcher, a talented post-doc with a significant track record in bioengineering, and the supervisor, a world leader in stem cell bioprocessing, whose group is embedded in one of Europe’s leading hubs for regenerative biomedicine. These working conditions will effectively promote the Researcher’s professional development, providing her with excellent new expertise in stem cell bioprocessing and fundamental leadership skills, significantly widening her career perspectives. The project outcomes will be of tremendous benefit to the European biomedical and pharmaceutical sectors, contributing to the European excellence, competitiveness and quality of life.

 Publications

year authors and title journal last update
List of publications.
2017 Diana Massai, Emiliano Bolesani, Diana Robles Diaz, Christina Kropp, Henning Kempf, Caroline Halloin, Ulrich Martin, Tudor Braniste, Giuseppe Isu, Vanessa Harms, Umberto Morbiducci, Gerald Dräger, Robert Zweigerdt
Sensitivity of human pluripotent stem cells to insulin precipitation induced by peristaltic pump-based medium circulation: considerations on process development
published pages: 1-15, ISSN: 2045-2322, DOI: 10.1038/s41598-017-04158-x 		Scientific Reports 7/1 2019-06-18
2017 Isotta Chimenti, Diana Massai, Umberto Morbiducci, Antonio Paolo Beltrami, Maurizio Pesce, Elisa Messina
Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up
published pages: 150-166, ISSN: 1937-5387, DOI: 10.1007/s12265-017-9741-5 		Journal of Cardiovascular Translational Research 10/2 2019-06-18
2017 Christina Kropp, Diana Massai, Robert Zweigerdt
Progress and challenges in large-scale expansion of human pluripotent stem cells
published pages: 244-254, ISSN: 1359-5113, DOI: 10.1016/j.procbio.2016.09.032 		Process Biochemistry 59 2019-06-18

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The information about "POSEIDON" are provided by the European Opendata Portal: CORDIS opendata.

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