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INPACT

Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INPACT project word cloud

Explore the words cloud of the INPACT project. It provides you a very rough idea of what is the project "INPACT" about.

peptide consolidated perfect judicious hoje de planktonic turn societal clinical resistant anticancer school penetrating specialised perspective iese proteins brazil virus international learning business innovative integrative acquire viral entrepreneurship pro cancers communication biotech trans spain media cyclic stanford effort smes aureus eg actively bacterial killing prostate rio ultra cancer science skills education proprietary highest barrier universities transferred bacteria academic janeiro peptides technologies formulations tailor economic ciencia cell drugs young itself dengue experts australia university biofilms industrial pathogenic life expertise contribution specialized environment drug inpact exchange allies chimeras supercharged portugal barcelona career

Project "INPACT" data sheet

The following table provides information about the project.

Coordinator	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	https://rise-inpact.com/
Total cost	1˙390˙500 €
EC max contribution	850˙500 € (61%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2014
Funding Scheme	MSCA-RISE
Starting year	2015
Duration (year-month-day)	from 2015-02-01 to 2019-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	463˙500.00
2	UNIVERSIDAD POMPEU FABRA UNIVERSIDAD POMPEU FABRA Organization address address: PLACA DE LA MERCE, 10-12 city: BARCELONA postcode: 8002 website: www.upf.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	180˙000.00
3	PROTEODESIGN SL PROTEODESIGN SL Organization address address: BALDIRI REIXAC 10-12 city: BARCELONA postcode: 8028 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	72˙000.00
4	UNIVERSIDAD DE NAVARRA UNIVERSIDAD DE NAVARRA Organization address address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL city: PAMPLONA postcode: 31080 website: www.unav.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PAMPLONA)	participant	49˙500.00
5	CENTRO ATLANTICO DEL MEDICAMENTO, SA CENTRO ATLANTICO DEL MEDICAMENTO, SA Organization address address: AVDA TRINIDAD 61 LA S/N PLANTA 7 AULARIO TORRE PROF AGUSTIN AREVALO city: SAN CRISTOBAL DE LA LAGUNA TENERIFE postcode: 38204 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SAN CRISTOBAL DE LA LAGUNA TENERIFE)	participant	45˙000.00
6	TECHNOPHAGE INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA SA TECHNOPHAGE INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA SA Organization address address: AVENIDA PROFESSOR EGAS MONIZ EDIFICIO EGAS MONIZ PISO 2 SALA A8 city: LISBOA postcode: 1649 028 website: www.technophage.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	40˙500.00
7	BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Organization address address: SERRA MALL 450 city: STANFORD postcode: 94305 2004 website: www.stanford.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (STANFORD)	partner	0.00
8	INSTITUTO CIENCIA HOJE-ICH INSTITUTO CIENCIA HOJE-ICH Organization address address: AV VENCESLAU BRAS 71 CASA 27 E PAVI LHAO MA BOTAFOGO city: RIO DE JANEIRO postcode: 22290 140 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BR (RIO DE JANEIRO)	partner	0.00
9	THE UNIVERSITY OF QUEENSLAND THE UNIVERSITY OF QUEENSLAND Organization address address: ST LUCIA city: BRISBANE postcode: 4072 website: http://www.uq.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (BRISBANE)	partner	0.00
10	UNIVERSIDADE FEDERAL DO RIO DE JANEIRO UNIVERSIDADE FEDERAL DO RIO DE JANEIRO Organization address address: AV BRIGADEIRO TROMPOWSKI SN 2 city: RIO DE JANEIRO postcode: 21941 590 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BR (RIO DE JANEIRO)	partner	0.00

Map

Project objective

INPACT aims at the pre-clinical development of innovative drugs and drug formulations against selected cancers (eg prostate cancer) and pathogenic bacteria (eg S. aureus). The INPACT consortium allies the expertise of both academic and industrial R&D partners that contribute with their own unique technologies to achieve new drugs that are only possible to develop in an integrative effort. Academic partners have unique knowledge and technologies on supercharged viral proteins-derived cell-penetrating peptides (eg from Dengue virus) and ultra-resistant cyclic peptides that may be transferred to the industrial partners, which in turn have specialized proprietary technologies on anticancer and/or peptide drugs’ technologies. The judicious exchange of knowledge among partners will lead to new resistant peptides for trans-barrier delivery of drugs (eg cyclic peptide-drug chimeras) and bacterial killing (both planktonic and biofilms). INPACT includes four leading academic partners (from Portugal, Spain, Australia, and Brazil) and three consolidated biotech SMEs (one from Portugal and two Spain). In addition to the R&D project itself, INPACT involves at the highest possible level a top business school in Europe (IESE, Barcelona, Spain), a consolidated media partner specialised in science communication (Ciencia Hoje, Rio de Janeiro, Brazil) and experts in international science funding from one of the top US universities (University of Stanford). The consortium will be the perfect environment for young researchers to acquire knowledge and skills in science, technology, entrepreneurship, business, and communication so they can pro-actively tailor their career path in a life-long learning perspective. This is a contribution towards the advancement of Europe through the use of research and education for societal development and economic growth.

Deliverables

List of deliverables.
Training and career development	Other	2019-09-02 14:01:24
Outreaching Outputs	Other	2019-09-02 14:01:24
Products	Other	2019-09-02 14:01:24
Dissemination Outputs	Other	2019-09-02 14:01:24

Take a look to the deliverables list in detail: detailed list of INPACT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	BÃ¡rbara Gomes, Marcelo T. Augusto, MÃ¡rio R. FelÃcio, Axel Hollmann, OctÃ¡vio L. Franco, SÃ³nia GonÃ§alves, Nuno C. Santos Designing improved active peptides for therapeutic approaches against infectious diseases published pages: 415-429, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2018.01.004	Biotechnology Advances 36/2	2019-09-02
2018	Marco Cavaco, Miguel A. R. B. Castanho, Vera Neves Peptibodies: An elegant solution for a long-standing problem published pages: e23095, ISSN: 2475-8817, DOI: 10.1002/bip.23095	Peptide Science 110/1	2019-09-02
2019	Luz N. Irazazabal, William F. Porto, Isabel C.M. Fensterseifer, Eliane S.F. Alves, Carolina O. Matos, AntÃ´nio C.S. Menezes, MÃ¡rio R. FelÃcio, SÃ³nia GonÃ§alves, Nuno C. Santos, Suzana M. Ribeiro, Vincent Humblot, Luciano M. LiÃ£o, Ali Ladram, Octavio L. Franco Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide published pages: 178-190, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2018.08.001	Biochimica et Biophysica Acta (BBA) - Biomembranes 1861/1	2019-09-02
2018	Clara PÃ©rez-Peinado, Susana Almeida Dias, Marco M. Domingues, AurÃ©lie H. Benfield, JoÃ£o Miguel Freire, Gandhi RÃ¡dis-Baptista, Diana Gaspar, Miguel A. R. B. Castanho, David J. Craik, SÃ³nia Troeira Henriques, Ana SalomÃ© Veiga, David Andreu Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15â€“34), antimicrobial peptides from rattlesnake venom published pages: 1536-1549, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.000125	Journal of Biological Chemistry 293/5	2019-09-02
2017	Juliana Perazzo, Miguel A. R. B. Castanho, SÃ³nia SÃ¡ Santos Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2016.00530	Frontiers in Pharmacology 7	2019-09-02
2017	Sara Neves-Coelho, Rute EleutÃ©rio, Francisco Enguita, Vera Neves, Miguel Castanho A New Noncanonical Anionic Peptide That Translocates a Cellular Bloodâ€“Brain Barrier Model published pages: 1753, ISSN: 1420-3049, DOI: 10.3390/molecules22101753	Molecules 22/10	2019-09-02
2016	Vera Neves, Frederico Aires-da-Silva, Sofia Corte-Real, Miguel A.R.B. Castanho Antibody Approaches To Treat Brain Diseases published pages: 36-48, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2015.10.005	Trends in Biotechnology 34/1	2019-09-02
2015	JoÃ£o M. Freire, Nuno C. Santos, Ana SalomÃ© Veiga, Andrea T. Da Poian, Miguel A. R. B. Castanho Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection published pages: 2267-2278, ISSN: 1742-464X, DOI: 10.1111/febs.13274	FEBS Journal 282/12	2019-09-02
2015	JoÃ£o M. Freire, Diana Gaspar, Ana SalomÃ© Veiga, Miguel A. R. B. Castanho Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells published pages: 178-185, ISSN: 1075-2617, DOI: 10.1002/psc.2741	Journal of Peptide Science 21/3	2019-09-02
2016	Suzana M. Ribeiro, MÃ¡rio R. FelÃcio, Esther Vilas Boas, SÃ³nia GonÃ§alves, FabrÃcio F. Costa, Ramar Perumal Samy, Nuno C. Santos, OctÃ¡vio L. Franco New frontiers for anti-biofilm drug development published pages: 133-144, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2016.02.006	Pharmacology & Therapeutics 160	2019-09-02
2016	Ludovico Migliolo, MÃ¡rio R. FelÃcio, Marlon H. Cardoso, Osmar N. Silva, Mary-Ann E. Xavier, Diego O. Nolasco, Adeliana Silva de Oliveira, Ignasi Roca-Subira, Jordi Vila Estape, Leandro D. Teixeira, Sonia M. Freitas, Anselmo J. Otero-Gonzalez, SÃ³nia GonÃ§alves, Nuno C. Santos, Octavio L. Franco Structural and functional evaluation of the palindromic alanine-rich antimicrobial peptide Pa-MAP2 published pages: 1488-1498, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2016.04.003	Biochimica et Biophysica Acta (BBA) - Biomembranes 1858/7	2019-09-02
2017	Vera Neves , Frederico Aires-da-Silva, MaurÃcio Morais, Lurdes Gano, Elisabete Ribeiro, AntÃ³nia Pinto, Sandra Aguiar, Diana Gaspar, CÃ©lia Fernandes, JoÃ£o D. G. Correia, and Miguel A. R. B. Castanho Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Bloodâ€“Brain Barrier through a Receptor-Free Mechanism published pages: , ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00087	ACS Chemical Biology	2019-09-02
2016	Marlon H. Cardoso, Suzana M. Ribeiro, Diego O. Nolasco, CÃ©sar de la Fuente-NÃºÃ±ez, MÃ¡rio R. FelÃcio, SÃ³nia GonÃ§alves, Carolina O. Matos, Luciano M. Liao, Nuno C. Santos, Robert E. W. Hancock, OctÃ¡vio L. Franco, Ludovico Migliolo A polyalanine peptide derived from polar fish with anti-infectious activities published pages: 21385, ISSN: 2045-2322, DOI: 10.1038/srep21385	Scientific Reports 6	2019-09-02
2017	Susana A. Dias, JoÃ£o M. Freire, Clara PÃ©rez-Peinado, Marco M. Domingues, Diana Gaspar, Nuno Vale, Paula Gomes, David Andreu, SÃ³nia T. Henriques, Miguel A. R. B. Castanho, Ana S. Veiga New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00775	Frontiers in Microbiology 8	2019-09-02
2017	SÃ³nia GonÃ§alves, PatrÃcia M. Silva, MÃ¡rio R. FelÃcio, Luciano N. de Medeiros, Eleonora Kurtenbach, Nuno C. Santos Psd1 Effects on Candida albicans Planktonic Cells and Biofilms published pages: , ISSN: 2235-2988, DOI: 10.3389/fcimb.2017.00249	Frontiers in Cellular and Infection Microbiology 7	2019-09-02
2017	MÃ¡rio R. FelÃcio, Osmar N. Silva, SÃ´nia GonÃ§alves, Nuno C. Santos, OctÃ¡vio L. Franco Peptides with Dual Antimicrobial and Anticancer Activities published pages: , ISSN: 1664-302X, DOI: 10.3389/fchem.2017.00005	Frontiers in Chemistry 5	2019-09-02
2016	Juliana Perazzo, MÃ´nica Lopes-Ferreira, SÃ³nia SÃ¡ Santos, Isa Serrano, AntÃ³nia Pinto, Carla Lima, Eduard Bardaji, Isaura Tavares, Montserrat Heras, Katia ConceiÃ§Ã£o, Miguel A. R. B. Castanho Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation published pages: 1130-1140, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.6b00099	ACS Chemical Neuroscience 7/8	2019-09-02
2017	Juliana Perazzo, Carla Lima, Montserrat Heras, Eduard BardajÃ, MÃ´nica Lopes-Ferreira, Miguel Castanho Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action published pages: 1663-1667, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.7b00007	ACS Chemical Neuroscience 8/8	2019-09-02
2017	Tiago N. Figueira, Filipa D. Oliveira, InÃªs Almeida, Ã‰rica O. Mello, Valdirene M. Gomes, Miguel A. R. B. Castanho, Diana Gaspar Challenging metastatic breast cancer with the natural defensin PvD 1 published pages: 16887-16899, ISSN: 2040-3364, DOI: 10.1039/c7nr05872a	Nanoscale 9/43	2019-09-02

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The information about "INPACT" are provided by the European Opendata Portal: CORDIS opendata.