VERTICAL CITY SIGNED
Versatility of scaffold complexes in vivo to control synaptic plasticity
Total Cost €
0EC-Contrib. €
0Partnership
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0VERTICAL CITY project word cloud
Explore the words cloud of the VERTICAL CITY project. It provides you a very rough idea of what is the project "VERTICAL CITY" about.
Project "VERTICAL CITY" data sheet
The following table provides information about the project.
| Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 1˙964˙199 € |
| EC max contribution | 1˙964˙199 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-06-01 to 2021-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | coordinator | 1˙964˙199.00 |
Map
Project objective
Receptors and associated scaffolds, together called receptosome, are relatively stable structures, but exchange of individual adaptor proteins can occur on a short time scale and in a highly regulated manner, which provides fine-tuning, speed, and specificity to the receptor signaling. Therefore, understanding how receptor function is affected by the composition and dynamics of complexes is an essential biological concern that will offer the opportunity to target exclusively the therapeutically relevant signaling pathway of a given receptor. We propose that in the brain, receptosome dynamics is involved in fine-tuning synaptic transmission and plasticity, which might be crucial for cognitive functions. First, we will establish the link between molecular events, neuronal signaling and memory performance. More than correlations, this project proposes live recording of molecular events and cellular signaling during memory encoding. Second, new specific therapeutic targets will be proposed for the treatment of cognitive deficiencies: instead of interfering with the ligand-biding pocket of the receptor, we propose to target specific scaffold interactions. This strategy will only modify a specific altered function of a receptor without modifying other functions (thus, avoiding undesired side effects). Third, within the scope of this proposal, we will develop innovative, powerful techniques that will be of high interest for a broad community of researchers in life sciences. These technologies will enable to monitor the versatility of protein-protein interactions in space and time ranging from in cellulo to in vivo BRET imaging in freely behaving animals. To conclude, we will establish the functional significance of oligomer remodeling in the physiological synaptic plasticity and try to restore it in neurological disorders.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Elise Goyet, Nathalie Bouquier, Vincent Ollendorff, Julie Perroy Fast and high resolution single-cell BRET imaging published pages: 28231, ISSN: 2045-2322, DOI: 10.1038/srep28231 |
Scientific Reports 6 | 2019-09-02 |
| 2017 |
Laura Ceolin, Nathalie Bouquier, Jihane Vitre-Boubaker, Stéphanie Rialle, Dany Severac, Emmanuel Valjent, Julie Perroy, Emma Puighermanal Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00340 |
Frontiers in Molecular Neuroscience 10 | 2019-09-02 |
| 2018 |
Yan Chastagnier, Enora Moutin, Anne-Laure Hemonnot, Julie Perroy Image Processing for Bioluminescence Resonance Energy Transfer Measurement—BRET-Analyzer published pages: , ISSN: 1662-5188, DOI: 10.3389/fncom.2017.00118 |
Frontiers in Computational Neuroscience 11 | 2019-09-02 |
| 2015 |
Weirui Guo, Laura Ceolin, Katie A. Collins, Julie Perroy, Kimberly M. Huber Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model published pages: , ISSN: 2211-1247, DOI: 10.1016/j.celrep.2015.11.013 |
Cell reports | 2019-09-02 |
| 2016 |
A. A. Pradhan, J. Perroy, W. M. Walwyn, M. L. Smith, A. Vicente-Sanchez, L. Segura, A. Bana, B. L. Kieffer, C. J. Evans Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function published pages: 3541-3551, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.4124-15.2016 |
Journal of Neuroscience 36/12 | 2019-09-02 |
| 2017 |
Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin, Bernard Mouillac, Julie Perroy, Thierry Durroux Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding published pages: , ISSN: , DOI: 10.1007/7355_2017_2 |
2019-09-02 |
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