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ADVANTAGE SIGNED

ADvanced Validation of A Novel TB Active disease diagnostic to address Global unmet needs: a European consortium approach

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 ADVANTAGE project word cloud

Explore the words cloud of the ADVANTAGE project. It provides you a very rough idea of what is the project "ADVANTAGE" about.

uk    regulatory    eight    tuberculosis    proof    hold    structured    security    globally    massive    cell    analytical    disruptive    1    reagents    packages    point    analytes    proven    breaking    rapid    million    transitioning    commercial    eradicate    successfully    mediated    risks    successful    companies    healthcare    proteinlogic    burden    poc    samples    laboratory    elusive    panel    protein    patient    reader    slow    diagnostic    care    tb    variety    biosensia    despite    confirm    validated    ground    validation    private    biomarkers    assay    poorly    bn    diagnostics    cartridge    creation    clinical    clear    accounting    profile    jobs    efforts    microfluidic    supply    plus    investment    advantage    demonstrated    unmet    human    commercialisation    performance    ing    improvements    global    company    practises    summary    yield    time    selective    reduce    active    instrument    platform    biomarker    deaths    400    costly    serum    standards    meet    stimulate   

Project "ADVANTAGE" data sheet

The following table provides information about the project.

Coordinator		 PROTEINLOGIC LIMITED 

Organization address
address: SHAKESPEARE HOUSE 42 NEWMARKET ROAD
city: CAMBRIDGE CAMBRIDGESHIRE
postcode: CB5 8EP
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website http://www.proteinlogic.com
 Total cost 3˙893˙307 €
 EC max contribution 3˙583˙396 € (92%)
 Programme 1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being)
2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
 Code Call H2020-SMEINST-2-2014
 Funding Scheme SME-2
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PROTEINLOGIC LIMITED UK (CAMBRIDGE CAMBRIDGESHIRE) coordinator 2˙921˙750.00
2    BIOSENSIA LIMITED IE (DUBLIN) participant 661˙646.00

Map

 Project objective

Tuberculosis (TB) remains an EU and global healthcare priority resulting in over 1.4 million deaths each year. Despite this and efforts to reduce TB by the EU commission, the WHO and others, a simple, rapid, diagnostic test for active tuberculosis (TB) remains elusive. Current diagnostic procedures, while accounting for over $1 bn globally, are poorly selective for active TB, hold risks for healthcare personnel, are slow to yield results and costly.

The large potential and high unmet need provide a clear target for commercialisation of a point-of-care (POC) test. Using over 400 clinical samples, ProteinLogic (a UK based diagnostics company) have demonstrated proof of concept for a ground-breaking approach using a panel of protein biomarkers on human serum samples that profile the cell mediated patient response to TB.

The objectives of the eight structured work packages within this three year project are to build on the validation of the biomarker TB panel transitioning from a laboratory assay to Biosensia’s novel microfluidic POC platform that has already been successfully proven with a variety of human analytes. Reagents will be developed as part of this project to ensure reduced costs and security of commercial supply. A unique instrument reader plus TB cartridge-based product will be developed to meet EU regulatory standards. The products will be validated in order to confirm analytical and clinical performance, and to provide evidence of major time, cost & performance improvements compared to current TB testing practises. Successful commercialisation will lead to the creation of over 30 new jobs and will stimulate further private investment in each of the companies.

In summary, ADVANTAGE has the potential to deliver a disruptive POC TB diagnostic test that can help eradicate the massive TB burden not only in EU but also globally.

 Deliverables

List of deliverables.
Clone scale Websites, patent fillings, videos etc. 2019-05-30 13:18:55

Take a look to the deliverables list in detail:  detailed list of ADVANTAGE deliverables.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ADVANTAGE" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "ADVANTAGE" are provided by the European Opendata Portal: CORDIS opendata.

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