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SmartMic

Smart Multimodal Microscopy for High-Throughput Developmental Biology in Real-Time

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SmartMic project word cloud

Explore the words cloud of the SmartMic project. It provides you a very rough idea of what is the project "SmartMic" about.

detection    fluorescence    spim    adaptively    life    illumination    integrate    flexible    limit    recording    photo    understand    fundamental    diffraction    limits    questions    systematically    platform    model    multimodal    microscopy    experiment    molecules    microscope    cells    systematic    embryonic    statistically    analyze    breaking    though    image    images    entirely    intact    pumped    automatically    resolution    time    learns    size    collect    spatial    sides    stereotypic    temporal    light    embryos    ground    tissues    fast    organisms    multiple    assemble    lack    pushed    hundreds    describe    data    speeds    samples    microscopes    toxicity    recorded    developmental    interplay    stream    draw    acquisition    fundamentally    plasticity    insights    smart    quest    establishing    reduces    amount    adaptive    dramatically    reduce    seconds    inner    workings    differ    biology    disciplinary    embryo    software    first    throughput    hard    imaged    living    acquire    sheet    feeder    single   

Project "SmartMic" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 2˙000˙000.00

Map

 Project objective

'Fluorescence microscopy is a key technology in our quest to understand fundamental developmental processes of life. High-resolution images recorded in intact, living organisms deliver insights into the complex interplay of molecules, cells and tissues in real time. Even though the resolution of microscopes has been pushed beyond the diffraction limit, providing important insights into the inner workings of single cells, we still lack an understanding of plasticity in development: How does one embryo differ from another and how can we describe the 'average', stereotypic embryo? To address this long-standing multi-disciplinary challenge, we propose to develop an entirely novel microscopy hard- and software platform to systematically image and analyze embryos in real time. We will design and assemble a fast and flexible multimodal light-sheet microscope (SPIM) with adaptive illumination and detection from multiple sides. A fundamentally new concept of this proposal is the ability to adaptively change the recording's spatial and temporal resolution during the experiment: The microscope learns to acquire only the data of interest. Using a high-throughput sample feeder, many samples can be automatically pumped through the microscope and imaged within seconds for large-scale comparative developmental studies. Real-time processing will dramatically reduce the size of the data stream and thus, provide for the first time a platform to collect data from hundreds of samples. At the same time, by establishing a model for the observed embryo, we will integrate information from multiple samples to draw statistically relevant conclusions. Our ground-breaking concept of smart microscopy speeds up the acquisition, reduces the amount of data and limits photo-toxicity. It enables us to address fundamental questions in embryonic development that are out of reach by traditional methods. Smart microscopy will open up a new field of research: systematic real-time developmental biology.'

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The information about "SMARTMIC" are provided by the European Opendata Portal: CORDIS opendata.

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