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SmartMic

Smart Multimodal Microscopy for High-Throughput Developmental Biology in Real-Time

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SmartMic project word cloud

Explore the words cloud of the SmartMic project. It provides you a very rough idea of what is the project "SmartMic" about.

describe    microscope    toxicity    hard    draw    differ    organisms    analyze    hundreds    systematic    recording    establishing    diffraction    light    single    image    acquisition    plasticity    stereotypic    platform    samples    multimodal    inner    spatial    fundamentally    living    embryo    feeder    though    developmental    interplay    imaged    amount    embryos    time    speeds    ground    microscopy    dramatically    size    intact    entirely    model    limit    fundamental    pumped    acquire    fluorescence    limits    assemble    recorded    software    integrate    photo    fast    workings    spim    understand    data    stream    cells    reduce    smart    disciplinary    throughput    tissues    detection    automatically    experiment    resolution    breaking    learns    sides    temporal    questions    insights    systematically    first    molecules    seconds    biology    adaptively    adaptive    statistically    multiple    illumination    embryonic    sheet    pushed    images    collect    microscopes    flexible    life    lack    quest    reduces   

Project "SmartMic" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 2˙000˙000.00

Map

 Project objective

'Fluorescence microscopy is a key technology in our quest to understand fundamental developmental processes of life. High-resolution images recorded in intact, living organisms deliver insights into the complex interplay of molecules, cells and tissues in real time. Even though the resolution of microscopes has been pushed beyond the diffraction limit, providing important insights into the inner workings of single cells, we still lack an understanding of plasticity in development: How does one embryo differ from another and how can we describe the 'average', stereotypic embryo? To address this long-standing multi-disciplinary challenge, we propose to develop an entirely novel microscopy hard- and software platform to systematically image and analyze embryos in real time. We will design and assemble a fast and flexible multimodal light-sheet microscope (SPIM) with adaptive illumination and detection from multiple sides. A fundamentally new concept of this proposal is the ability to adaptively change the recording's spatial and temporal resolution during the experiment: The microscope learns to acquire only the data of interest. Using a high-throughput sample feeder, many samples can be automatically pumped through the microscope and imaged within seconds for large-scale comparative developmental studies. Real-time processing will dramatically reduce the size of the data stream and thus, provide for the first time a platform to collect data from hundreds of samples. At the same time, by establishing a model for the observed embryo, we will integrate information from multiple samples to draw statistically relevant conclusions. Our ground-breaking concept of smart microscopy speeds up the acquisition, reduces the amount of data and limits photo-toxicity. It enables us to address fundamental questions in embryonic development that are out of reach by traditional methods. Smart microscopy will open up a new field of research: systematic real-time developmental biology.'

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The information about "SMARTMIC" are provided by the European Opendata Portal: CORDIS opendata.

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