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MolCellTissMech SIGNED

Molecular and cellular determinants of cell monolayer mechanics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MolCellTissMech project word cloud

Explore the words cloud of the MolCellTissMech project. It provides you a very rough idea of what is the project "MolCellTissMech" about.

biophysics turnover sensed load characterise protein theoretical imaging structures behaviours simplest roles characterisation dictated times overcome tissues dissect acting division instrument internal determinants resolutions quantitative molecular contractility epithelial devised understand cell subcellular constituent organisation tension monolayers fundamental sense intercalation lacking interface separate mechanics bearing proteins phenomena diseases monolayer syncitium govern participating rearrangements adhesive cytoskeletal scales individual organisms participate intrinsic epithelia mutations body adult descriptions forces cellular tissue discover technique fragilised morphogenesis amongst living play single unfolding external longer cells stage time drive mechanical lab environment

Project "MolCellTissMech" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	2˙000˙000 €
EC max contribution	2˙000˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	2˙000˙000.00

Map

Project objective

Epithelial monolayers are amongst the simplest tissues in the body, yet they play fundamental roles in adult organisms where they separate the internal environment from the external environment and in development when the intrinsic forces generated by cells within the monolayer drive tissue morphogenesis. The mechanics of these simple tissues is dictated by the cytoskeletal and adhesive proteins that interface the constituent cells into a tissue-scale mechanical syncitium. Mutations in these proteins lead to diseases with fragilised epithelia. However, a quantitative understanding of how subcellular structures govern monolayer mechanics, how cells sense their mechanical environment and what mechanical forces participate in tissue morphogenesis is lacking.

To overcome these challenges, my lab devised a new technique to study the mechanics of load-bearing monolayers under well-controlled mechanical conditions while allowing imaging at subcellular, cellular and tissue resolutions. Using this instrument, my proposal aims to understand the molecular determinants of monolayer mechanics as well as the cellular behaviours that drive tissue morphogenesis. I will focus on four objectives: 1) discover the molecular determinants of monolayer mechanics, 2) characterise monolayer mechanics, 3) dissect how tension is sensed by monolayers, and 4) investigate the biophysics of individual cell behaviours participating in tissue morphogenesis.

Together these studies will enable us to understand how monolayer mechanics is affected by changes in single cell behaviour, subcellular organisation, and molecular turnover. This multi-scale characterisation of monolayer mechanics will set the stage for new theoretical descriptions of living tissues involving both molecular-scale phenomena (cytoskeletal turnover, contractility, and protein unfolding) operating on short time-scales and rearrangements due to cell-scale phenomena (cell intercalation, cell division) acting on longer times.

Publications

List of publications.
year	authors and title	journal	last update
2020	A. Bonfanti, J. Fouchard, N. Khalilgharibi, G. Charras, A. Kabla A unified rheological model for cells and cellularised materials published pages: 190920, ISSN: 2054-5703, DOI: 10.1098/rsos.190920	Royal Society Open Science 7/1	2020-03-13
2019	Nargess Khalilgharibi, Jonathan Fouchard, Nina Asadipour, Ricardo Barrientos, Maria Duda, Alessandra Bonfanti, Amina Yonis, Andrew Harris, Payman Mosaffa, Yasuyuki Fujita, Alexandre Kabla, Yanlan Mao, Buzz Baum, JosÃ© J MuÃ±oz, Mark Miodownik, Guillaume Charras Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex published pages: 839-847, ISSN: 1745-2473, DOI: 10.1038/s41567-019-0516-6	Nature Physics 15/8	2020-03-13
2020	Jonathan Fouchard, Tom Wyatt, Amsha Proag, Ana Lisica, Nargess Khalilgharibi, Pierre Recho, Magali Suzanne, Alexandre Kabla, Guillaume Charras Curling of epithelial monolayers reveals coupling between active bending and tissue tension published pages: In Press, ISSN: 0027-8424, DOI:	Proceedings of the National Academy of Sciences, USA	2020-03-13
2020	Luyan Cao, Amina Yonis, Malti Vaghela, Elias H Barriga, Priyamvada Chugh, Matthew B Smith, Julien Maufront, GeneviÃ¨ve Lavoie, Antoine MÃ©ant, Emma Ferber, Miia Bovellan, Art Alberts, AurÃ©lie Bertin, Roberto Mayor, Ewa K. Paluch, Philippe P. Roux, Antoine JÃ©gou, Guillaume Romet-Lemonne, Guillaume Charras SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organisation published pages: In Press, ISSN: 1465-7392, DOI:	Nature Cell Biology	2020-03-13
2019	Maria Duda, Natalie J. Kirkland, Nargess Khalilgharibi, Melda Tozluoglu, Alice C. Yuen, Nicolas Carpi, Anna Bove, Matthieu Piel, Guillaume Charras, Buzz Baum, Yanlan Mao Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress published pages: 245-260.e7, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.12.020	Developmental Cell 48/2	2020-03-13
2020	Tom P. J. Wyatt, Jonathan Fouchard, Ana Lisica, Nargess Khalilgharibi, Buzz Baum, Pierre Recho, Alexandre J. Kabla, Guillaume T. Charras Actomyosin controls planarity and folding of epithelia in response to compression published pages: 109-117, ISSN: 1476-1122, DOI: 10.1038/s41563-019-0461-x	Nature Materials 19/1	2020-03-13
2016	Nargess Khalilgharibi, Jonathan Fouchard, Pierre Recho, Guillaume Charras, Alexandre Kabla The dynamic mechanical properties of cellularised aggregates published pages: 113-120, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2016.06.003	Current Opinion in Cell Biology 42	2019-05-31
2016	Wyatt T., Charras G., Baum B. A question of time: tissue adaptation to mechanical forces published pages: , ISSN: 0955-0674, DOI: 10.1016/j.ceb.2016.02.012	Current Opinion in Cell Biology	2019-05-31
2017	LÃ©o Valon, Ariadna MarÃn-LlauradÃ³, Thomas Wyatt, Guillaume Charras, Xavier Trepat Optogenetic control of cellular forces and mechanotransduction published pages: 14396, ISSN: 2041-1723, DOI: 10.1038/ncomms14396	Nature Communications 8	2019-05-31
2018	Elias H. Barriga, Kristian Franze, Guillaume Charras, Roberto Mayor Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo published pages: 523-527, ISSN: 0028-0836, DOI: 10.1038/nature25742	Nature 554/7693	2019-05-31

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