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PHII SIGNED

PTX3 in Humoral Innate Immunity

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PHII project word cloud

Explore the words cloud of the PHII project. It provides you a very rough idea of what is the project "PHII" about.

oncosuppressor cancer innate inflammation structural functions mouse complement repair immunity microbe arm tested ph molecule line cdna recognition interplay mode data tool immune collectins cancers dissect explore acidic human cellular recruitment vistas tumor carcinogenesis acts microenvironment cells tissue molecules murine matrix first extrinsic ficolins pentraxin genomic humoral diversity pentraxins unexpected microenvironmental signal function hypothesis suppressing ptx3 molecular preliminary fluid inflammatory pattern components prototypic

Project "PHII" data sheet

The following table provides information about the project.

Coordinator	HUMANITAS MIRASOLE SPA Organization address address: VIA MANZONI 56 city: ROZZANO (MI) postcode: 20100 website: www.humanitas.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	2˙497˙081 €
EC max contribution	2˙497˙081 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-ADG
Funding Scheme	ERC-ADG
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HUMANITAS MIRASOLE SPA HUMANITAS MIRASOLE SPA Organization address address: VIA MANZONI 56 city: ROZZANO (MI) postcode: 20100 website: www.humanitas.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROZZANO (MI))	coordinator	2˙497˙081.00

Map

Project objective

The innate immune system includes a cellular and a humoral arm. Structural diversity is a characteristic of humoral fluid phase pattern recognition molecules. These include complement components, collectins, ficolins, and pentraxins. We have used the long pentraxin PTX3, identified by the applicant (cDNA and genomic, mouse and human), as a prototypic fluid phase pattern recognition molecule to dissect its function, as well as to define general properties of humoral innate immunity and its interplay with the cellular arm. The general objective of this application is to explore unexpected vistas on humoral innate immunity, using PTX3 as a molecular tool. Specifically two hypothesis will be tested based on preliminary data. First the applicant will test the hypothesis that matrix and microbe recognition are related functions of PTX3 and that a microenvironmental signal (acidic pH) sets PTX3 in a matrix recognition, tissue repair mode. A second related line of work will focus on inflammation as a key component of the tumor microenvironment. The applicant will test the hypothesis that PTX3 and elements of the humoral innate immune system are essential components of cancer related inflammation. In particular, based on preliminary data, the hypothesis will be tested that PTX3 acts as an extrinsic oncosuppressor in murine carcinogenesis and in selected human cancers by suppressing the recruitment of tumor-promoting inflammatory cells. These studies are expected to provide new unexpected vistas on the humoral arm of the innate immune system.

Publications

List of publications.
year	authors and title	journal	last update
2018	Martina Molgora, Domenico Supino, Domenico Mavilio, Angela Santoni, Lorenzo Moretta, Alberto Mantovani, Cecilia Garlanda The yin-yang of the interaction between myelomonocytic cells and NK cells published pages: e12705, ISSN: 0300-9475, DOI: 10.1111/sji.12705	Scandinavian Journal of Immunology 88/3	2020-04-24
2019	Fabrizia Bonacina, Annalisa Moregola, RÃ©mi Porte, Andrea Baragetti, Eduardo Bonavita, Alice Salatin, Liliana Grigore, Fabio Pellegatta, Martina Molgora, Marina Sironi, Elisa Barbati, Alberto Mantovani, Barbara Bottazzi, Alberico Luigi Catapano, Cecilia Garlanda, Giuseppe Danilo Norata Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity published pages: 1861-1872, ISSN: 0008-6363, DOI: 10.1093/cvr/cvz068	Cardiovascular Research 115/13	2020-04-24
2019	Andrea Doni, Matteo Stravalaci, Antonio Inforzato, Elena Magrini, Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00712	Frontiers in Immunology 10	2020-04-24
2019	Andrea Ponzetta, Roberta Carriero, Silvia Carnevale, Marialuisa Barbagallo, Martina Molgora, Chiara Perucchini, Elena Magrini, Francesca Gianni, Paolo Kunderfranco, Nadia Polentarutti, Fabio Pasqualini, Sabrina Di Marco, Domenico Supino, Clelia Peano, Ferdinando Cananzi, Piergiuseppe Colombo, Silvana Pilotti, Suliman Yousef Alomar, Eduardo Bonavita, Maria Rosaria Galdiero, Cecilia Garlanda, Albert Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors published pages: 346-360.e24, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.05.047	Cell 178/2	2020-04-24
2019	Giuseppe A. Ramirez, Patrizia Rovere-Querini, Miriam Blasi, Silvia Sartorelli, Maria Chiara Di Chio, Mattia Baldini, Rebecca De Lorenzo, Enrica P. Bozzolo, Roberto Leone, Alberto Mantovani, Angelo A. Manfredi, Enrico Tombetti PTX3 Intercepts Vascular Inflammation in Systemic Immune-Mediated Diseases published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01135	Frontiers in Immunology 10	2020-04-24
2019	Giuseppe Ristagno, Francesca Fumagalli, Barbara Bottazzi, Alberto Mantovani, Davide Olivari, Deborah Novelli, Roberto Latini Pentraxin 3 in Cardiovascular Disease published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00823	Frontiers in Immunology 10	2020-04-24
2017	Alberto Mantovani Wandering pathways in the regulation of innate immunity and inflammation published pages: 1-5, ISSN: 0896-8411, DOI: 10.1016/j.jaut.2017.10.007	Journal of Autoimmunity 85	2020-02-12
2018	Danka GrÄeviÄ‡, Marina Sironi, Sonia Valentino, Livija Deban, Hrvoje Cvija, Antonio Inforzato, NataÅ¡a KovaÄiÄ‡, Vedran KataviÄ‡, Tomislav Kelava, Ivo KalajziÄ‡, Alberto Mantovani, Barbara Bottazzi The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair published pages: 1-18, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00417	Frontiers in Immunology 9	2020-02-12
2017	Mihai G Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y Donath, Evangelos J Giamarellos-Bourboulis, Douglas Golenbock, Mark S Gresnigt, Michael T Heneka, Hal M Hoffman, Richard Hotchkiss, Leo A B Joosten, Daniel L Kastner, Martin Korte, Eicke Latz, Peter Libby, Thomas Mandrup-Poulsen, Alberto Mantovani, Kingston H G Mills, Kristen L Nowak, Luke A O\'Neill, Peter Pickkers, Tom van A guiding map for inflammation published pages: 826-831, ISSN: 1529-2908, DOI: 10.1038/NI.3790	Nature Immunology 18/8	2020-02-12
2018	Cecilia Garlanda, Barbara Bottazzi, Elena Magrini, Antonio Inforzato, Alberto Mantovani PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer published pages: 623-639, ISSN: 0031-9333, DOI: 10.1152/physrev.00016.2017	Physiological Reviews 98/2	2020-02-12
2017	Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, Federica Riva, Marialuisa Barbagallo, SÃ©bastien Jaillon, Branka PopoviÄ‡, Giovanni Bernardini, Elena Magrini, Francesca Gianni, Santiago Zelenay, Stipan JonjiÄ‡, Angela Santoni, Cecilia Garlanda, Alberto Mantovani IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity published pages: 110-114, ISSN: 0028-0836, DOI: 10.1038/NATURE24293	Nature 551/7678	2020-02-12
2017	Marcello Rubino, Paolo Kunderfranco, Gianluca Basso, Carolina Magdalen Greco, Fabio Pasqualini, Simone Serio, Massimo Roncalli, Luigi Laghi, Alberto Mantovani, Roberto Papait, Cecilia Garlanda Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer published pages: e1333215, ISSN: 2162-402X, DOI: 10.1080/2162402X.2017.1333215	OncoImmunology	2020-02-12
2018	Martina Molgora, Domenico Supino, Alberto Mantovani, Cecilia Garlanda Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8 published pages: 233-247, ISSN: 0105-2896, DOI: 10.1111/imr.12609	Immunological Reviews 281/1	2020-02-12
2018	Alberto Mantovani, Isabella Barajon, Cecilia Garlanda IL-1 and IL-1 regulatory pathways in cancer progression and therapy published pages: 57-61, ISSN: 0105-2896, DOI: 10.1111/imr.12614	Immunological Reviews 281/1	2020-02-12
2018	Alberto Mantovani Redundancy and robustness versus division of labour and specialization in innate immunity published pages: 28-30, ISSN: 1044-5323, DOI: 10.1016/j.smim.2017.12.006	Seminars in Immunology 36	2020-02-12
2017	Andrea Doni, Giovanna D\'Amico, Diego Morone, Alberto Mantovani, Cecilia Garlanda Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage published pages: 31-40, ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2016.07.026	Seminars in Cell & Developmental Biology 61	2020-02-12
2017	Annalisa Del Prete, Laura MartÃnez-MuÃ±oz, Cristina Mazzon, Lara Toffali, Francesca Sozio, Lorena Za, Daniela Bosisio, Luisa Gazzurelli, Valentina Salvi, Laura Tiberio, Chiara Liberati, Eugenio Scanziani, Annunciata Vecchi, Carlo Laudanna, Mario Mellado, Alberto Mantovani, Silvano Sozzani The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage published pages: 1223-1234, ISSN: 0006-4971, DOI: 10.1182/blood-2017-04-777680	Blood 130/10	2020-02-12
2018	Giulia Marelli, Roberta Avigni, Paola Allavena, Cecilia Garlanda, Alberto Mantovani, Andrea Doni, Marco Erreni *\"Optical in vivo* imaging detection of preclinical models of gut tumors through the expression of Integrin αVβ3\"** published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.25826	Oncotarget 9/59	2020-02-12

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