Explore the words cloud of the RELEVANCE project. It provides you a very rough idea of what is the project "RELEVANCE" about.
The following table provides information about the project.
Coordinator |
UNIVERSITAT ZURICH
Organization address contact info |
Coordinator Country | Switzerland [CH] |
Project website | http://relevance.arivis.com/ |
Total cost | 3˙896˙558 € |
EC max contribution | 3˙896˙558 € (100%) |
Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
Code Call | H2020-MSCA-ITN-2015 |
Funding Scheme | MSCA-ITN-ETN |
Starting year | 2015 |
Duration (year-month-day) | from 2015-09-01 to 2019-08-31 |
Take a look of project's partnership.
Anaemia is the most common pathological condition affecting 1.6 billion individuals worldwide. It thus presents a serious health care problem and an economic burden. Reduction in red blood cell (RBC) number can be caused by blood loss, diet, stress conditions including endurance sport, and pathologies which are caused by primary genetic aberrations or are secondary to the malfunction of other cell types. Transfusion of RBC, which is often the only cure for severe cases of anaemia, is associated with risks such as thrombosis and transfusion reactions due to allo-immunisation. There is an unmet need to improve treatment of anaemia through early and accurate diagnosis, targeted treatment, and increased safety and effectiveness of RBC transfusion. The aim of RELEVANCE is to improve fast and cost-effective diagnosis of the underlying cause of primary anaemia, and to improve treatment options for both general and personalised medicine. We defined five key objectives: (1) to improve diagnostics of anaemia, particularly for hereditary rare forms of anaemia (RA); (2) to find novel treatments for anaemia that target RBC production, ageing and clearance; (3) to reduce premature loss of RBC following transfusion; (4) to produce cultured RBC for transfusion; (5) to monitor and optimise RBC function during sport and exercise. RELEVANCE will train 15 early stage researchers (ESR) at four SMEs and eight academic partners, two of whom are at blood supply centres and two are diagnostic centres for RA. The continuous interactions between the clinic, blood supply centers, basic research, and industry will select for the most relevant unmet medical needs, and will stimulate innovative procedures that are immediately probed for applicability and validity both in a research and a clinical setting. RELEVANCE will organize three open access summer schools, extending training beyond the ESR of the ITN sustaining the critical number of young talented professionals in the field.
Dissemination Toolkit | Other | 2019-06-19 13:43:25 |
Website | Websites, patent fillings, videos etc. | 2019-06-19 13:43:25 |
Training Schools | Other | 2019-06-19 13:43:25 |
Outreach activities | Documents, reports | 2019-06-19 13:43:25 |
Take a look to the deliverables list in detail: detailed list of RELEVANCE deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Benoit P Nicolet, Sander Engels, Francesca Aglialoro, Emile van den Akker, Marieke von Lindern, Monika C Wolkers Circular RNA expression in human hematopoietic cells is widespread and cell-type specific published pages: 8168-8180, ISSN: 0305-1048, DOI: 10.1093/nar/gky721 |
Nucleic Acids Research 46/16 | 2020-02-06 |
2018 |
Esther Heideveld, Lea A. Hampton-O’Neil, Stephen J. Cross, Floris P.J. van Alphen, Maartje van den Biggelaar, Ashley M. Toye, Emile van den Akker Glucocorticoids induce differentiation of monocytes towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages published pages: 395-405, ISSN: 0390-6078, DOI: 10.3324/haematol.2017.179341 |
Haematologica 103/3 | 2020-02-05 |
2019 |
Marea V.E. Rijst, Lesley Voorn, Barbera Veldhuisen, John M. Jongerius, Emile Akker, C. Ellen Schoot Identification of a novel singleâ€nucleotide mutation in SMIM1 gene that results in low Vel antigen expression published pages: , ISSN: 0041-1132, DOI: 10.1111/trf.15411 |
Transfusion 59/10 | 2020-02-05 |
2018 |
Jizhi Wen, Onno J.H.M. Verhagen, Shuangshuang Jia, Qianni Liang, Zhen Wang, Ling Wei, Hong Luo, Guangping Luo, Gestur Vidarsson, Emile Akker, Yanli Ji, C. Ellen Schoot A variant RhAG protein encoded by the RHAG*572A allele causes serological weak D expression while maintaining normal RhCE phenotypes published pages: 405-411, ISSN: 0041-1132, DOI: 10.1111/trf.14969 |
Transfusion 59/1 | 2020-02-05 |
2018 |
Fiamma Salerno, Sander Engels, Maartje van den Biggelaar, Floris P. J. van Alphen, Aurelie Guislain, Wanqi Zhao, Deborah L. Hodge, Sarah E. Bell, Jan Paul Medema, Marieke von Lindern, Martin Turner, Howard A. Young, Monika C. Wolkers Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells published pages: 828-837, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0155-6 |
Nature Immunology 19/8 | 2020-02-05 |
2018 |
Pedro L. Moura, Bethan R. Hawley, Tosti J. Mankelow, Rebecca E. Griffiths, Johannes G.G. Dobbe, Geert J. Streekstra, David J. Anstee, Timothy J. Satchwell, Ashley M. Toye Non-muscle myosin II drives vesicle loss during human reticulocyte maturation published pages: 1997-2007, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.199083 |
Haematologica 103/12 | 2020-02-05 |
2019 |
Timothy J. Satchwell, Katherine E. Wright, Katy L. Haydn-Smith, Fernando Sánchez-Román Terán, Pedro L. Moura, Joseph Hawksworth, Jan Frayne, Ashley M. Toye, Jake Baum Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11790-w |
Nature Communications 10/1 | 2020-02-05 |
2019 |
Guoqiang Yi, Amit Mandoli, Laura Jussen, Esther Tijchon, Maaike G. J. M. van Bergen, Gaëlle Cordonnier, Marten Hansen, Bowon Kim, Luan N. Nguyen, Pascal W. T. C. Jansen, Michiel Vermeulen, Bert van der Reijden, Emile van den Akker, Jonathan Bond, Joost H. A. Martens CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1 published pages: , ISSN: 2044-5385, DOI: 10.1038/s41408-019-0194-8 |
Blood Cancer Journal 9/3 | 2020-02-05 |
2019 |
Steven Heshusius, Esther Heideveld, Patrick Burger, Marijke Thiel-Valkhof, Erica Sellink, Eszter Varga, Elina Ovchynnikova, Anna Visser, Joost H. A. Martens, Marieke von Lindern, Emile van den Akker Large-scale in vitro production of red blood cells from human peripheral blood mononuclear cells published pages: 3337-3350, ISSN: 2473-9529, DOI: 10.1182/bloodadvances.2019000689 |
Blood Advances 3/21 | 2020-02-05 |
2020 |
Elie Nader, David Monedero, Mélanie Robert, Sarah Skinner, Emeric Stauffer, Agnès Cibiel, Michèle Germain, Jules Hugonnet, Alexander Scheer, Philippe Joly, Céline Renoux, Philippe Connes, Stéphane Égée Impact of a 10 km running trial on eryptosis, red blood cell rheology, and electrophysiology in endurance trained athletes: a pilot study published pages: 255-266, ISSN: 1439-6319, DOI: 10.1007/s00421-019-04271-x |
European Journal of Applied Physiology 120/1 | 2020-02-05 |
2019 |
Claudia Bernecker, Mania Ackermann, Nico Lachmann, Lisa Rohrhofer, Holm Zaehres, Marcos J. Araúzo-Bravo, Emile van den Akker, Peter Schlenke, Isabel Dorn Enhanced Ex Vivo Generation of Erythroid Cells from Human Induced Pluripotent Stem Cells in a Simplified Cell Culture System with Low Cytokine Support published pages: 1540-1551, ISSN: 1547-3287, DOI: 10.1089/scd.2019.0132 |
Stem Cells and Development 28/23 | 2020-02-05 |
2019 |
T. R. L. Klei, F. Aglialoro, F. P. J. Mul, S. Tol, P. C. Ligthart, I. M. Seignette, J. Geissler, E. van den Akker, R. van Bruggen Differential interaction between DARC and SDF-1 on erythrocytes and their precursors published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-52186-6 |
Scientific Reports 9/1 | 2020-02-05 |
2019 |
Virginia Pretini, Mischa H. Koenen, Lars Kaestner, Marcel H. A. M. Fens, Raymond M. Schiffelers, Marije Bartels, Richard Van Wijk Red Blood Cells: Chasing Interactions published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00945 |
Frontiers in Physiology 10 | 2020-02-05 |
2019 |
Laura Hertz, Sandra Ruppenthal, Greta Simionato, Stephan Quint, Alexander Kihm, Asena Abay, Polina Petkova-Kirova, Ulrich Boehm, Petra Weissgerber, Christian Wagner, Matthias W. Laschke, Lars Kaestner The Evolution of Erythrocytes Becoming Red in Respect to Fluorescence published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00753 |
Frontiers in Physiology 10 | 2020-02-05 |
2019 |
Pedro L. Moura, Bethan R. Hawley, Johannes G.G. Dobbe, Geert J. Streekstra, Minke A.E. Rab, Paola Bianchi, Richard van Wijk, Ashley M. Toye, Timothy J. Satchwell PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis published pages: haematol.2019.23, ISSN: 0390-6078, DOI: 10.3324/haematol.2019.231159 |
Haematologica | 2020-02-05 |
2018 |
Nahuel A. Paolini, Kat S. Moore, Franca M. di Summa, Ivo F. A. C. Fokkema, Peter A. C. ‘t Hoen, Marieke von Lindern Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors published pages: e0193790, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193790 |
PLOS ONE 13/4 | 2020-02-05 |
2019 |
Marten Hansen, Marieke von Lindern, Emile van den Akker, Eszter Varga Humanâ€induced pluripotent stem cellâ€derived blood products: state of the art and future directions published pages: 3288-3303, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13599 |
FEBS Letters 593/23 | 2020-02-05 |
2018 |
Andrew Bañas, Stephen Daedalus Separa, Einstom Engay, Jesper Glückstad Point spread function shaping using geometric analysis published pages: 522-527, ISSN: 0030-4018, DOI: 10.1016/j.optcom.2018.06.068 |
Optics Communications 427 | 2020-02-05 |
2019 |
Ileana Cantú, Harmen J. G. van de Werken, Nynke Gillemans, Ralph Stadhouders, Steven Heshusius, Alex Maas, Fatemehsadat Esteghamat, Zeliha Ozgur, Wilfred F. J. van IJcken, Frank Grosveld, Marieke von Lindern, Sjaak Philipsen, Thamar B. van Dijk The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation published pages: e0208659, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0208659 |
PLOS ONE 14/3 | 2020-02-05 |
2019 |
Marea V.E. van der Rijst, Suzanne N. Lissenberg-Thunnissen, Peter C. Ligthart, Remco Visser, John M. Jongerius, Lesley Voorn, Barbera Veldhuisen, Gestur Vidarsson, Emile van den Akker, C. Ellen van der Schoot Development of a recombinant anti-Vel immunoglobulin M to identify Vel-negative donors published pages: 1359-1366, ISSN: 0041-1132, DOI: 10.1111/trf.15147 |
Transfusion 59/4 | 2020-02-05 |
2019 |
Einstom Engay, Andrew Bañas, Ada-Ioana Bunea, Stephen Daedalus Separa, Jesper Glückstad Interferometric detection of OAM-carrying Helico-conical beams published pages: 247-251, ISSN: 0030-4018, DOI: 10.1016/j.optcom.2018.10.019 |
Optics Communications 433 | 2020-02-05 |
2018 |
Christian Bächer, Alexander Kihm, Lukas Schrack, Lars Kaestner, Matthias W. Laschke, Christian Wagner, Stephan Gekle Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels published pages: 411-425, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.06.013 |
Biophysical Journal 115/2 | 2020-02-05 |
2019 |
Martha Lopez-Yrigoyen, Cheng-Tao Yang, Antonella Fidanza, Luca Cassetta, A. Helen Taylor, Angela McCahill, Erica Sellink, Marieke von Lindern, Emile van den Akker, Joanne C. Mountford, Jeffrey W. Pollard, Lesley M. Forrester Genetic programming of macrophages generates an in vitro model for the human erythroid island niche published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08705-0 |
Nature Communications 10/1 | 2020-02-05 |
2018 |
Marten Hansen, Eszter Varga, Cathelijn Aarts, Tatjana Wust, Taco Kuijpers, Marieke von Lindern, Emile van den Akker Efficient production of erythroid, megakaryocytic and myeloid cells, using single cell-derived iPSC colony differentiation published pages: 232-244, ISSN: 1873-5061, DOI: 10.1016/j.scr.2018.04.016 |
Stem Cell Research 29 | 2020-02-05 |
2018 |
Lars Kaestner, Stephane Egee Commentary: Voltage Gating of Mechanosensitive PIEZO Channels published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01565 |
Frontiers in Physiology 9 | 2020-02-05 |
2018 |
Kat S. Moore, Nurcan Yagci, Floris van Alphen, Nahuel A. Paolini, Rastislav Horos, Ntsiki M. Held, Riekelt H. Houtkooper, Emile van den Akker, Alexander B. Meijer, Peter A. C. ‘t Hoen, Marieke von Lindern Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-20518-7 |
Scientific Reports 8/1 | 2020-02-05 |
2019 |
Pedro L. Moura, Maria A. Lizarralde Iragorri, Olivier Français, Bruno Le Pioufle, Johannes G. G. Dobbe, Geert J. Streekstra, Wassim El Nemer, Ashley M. Toye, Timothy J. Satchwell Reticulocyte and red blood cell deformation triggers specific phosphorylation events published pages: 2653-2663, ISSN: 2473-9529, DOI: 10.1182/bloodadvances.2019000545 |
Blood Advances 3/17 | 2020-02-05 |
2019 |
Rinske van Oorschot, Marten Hansen, Johanna M. Koornneef, Anna E. Marneth, Saskia M. Bergevoet, Maaike G.J.M. van Bergen, Floris P.J. van Alphen, Carmen van der Zwaan, Joost H.A. Martens, Michiel Vermeulen, Pascal W.T.C. Jansen, Marijke P.A. Baltissen, Britta A.P. Laros-van Gorkom, Hans Janssen, Joop H. Jansen, Marieke von Lindern, Alexander B. Meijer, Emile van den Akker, Bert A. van der Reijden Molecular mechanisms of bleeding disorderassociated GFI1B Q287* mutation and its affected pathways in megakaryocytes and platelets published pages: 1460-1472, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.194555 |
Haematologica 104/7 | 2020-02-05 |
2018 |
Kat S. Moore, Nurcan Yagci, Floris van Alphen, Alexander B. Meijer, Peter A. C. ‘t Hoen, Marieke von Lindern Strap associates with Csde1 and affects expression of select Csde1-bound transcripts published pages: e0201690, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0201690 |
PLOS ONE 13/8 | 2020-02-05 |
2019 |
Andrew Bañas, Einstom Engay, Ada-Ioana Bunea, Stephen Daedalus Separa, Jesper Glückstad Three-dimensional light sculpting using a geometric analysis published pages: 210-215, ISSN: 0030-4018, DOI: 10.1016/j.optcom.2018.09.036 |
Optics Communications 431 | 2020-02-05 |
2018 |
Kat S. Moore, Marieke von Lindern RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00910 |
Frontiers in Physiology 9 | 2020-02-05 |
2018 |
Lars Kaestner, Anna Bogdanova Editorial: The Red Cell Life-Cycle From Erythropoiesis to Clearance published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01537 |
Frontiers in Physiology 9 | 2020-02-04 |
2019 |
Asena Abay, Greta Simionato, Revaz Chachanidze, Anna Bogdanova, Laura Hertz, Paola Bianchi, Emile van den Akker, Marieke von Lindern, Marc Leonetti, Giampaolo Minetti, Christian Wagner, Lars Kaestner Glutaraldehyde – A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00514 |
Frontiers in Physiology 10 | 2020-02-04 |
2018 |
Mégane Brusson, Maria De Grandis, Sylvie Cochet, Sylvain Bigot, Mickaël Marin, Marjorie Leduc, François Guillonneau, Patrick Mayeux, Thierry Peyrard, Christine Chomienne, Caroline Le Van Kim, Bruno Cassinat, Jean-Jacques Kiladjian, Wassim El Nemer Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera published pages: 972-981, ISSN: 0390-6078, DOI: 10.3324/haematol.2017.182303 |
Haematologica 103/6 | 2020-02-04 |
2017 |
Makhro, Asya; Kaestner, Lars; Bogdanova, Anna NMDA receptor activity in circulating red blood cells: methods of detection published pages: , ISSN: , DOI: 10.5167/uzh-140866 |
Makhro, Asya; Kaestner, Lars; Bogdanova, Anna (2017). NMDA receptor activity in circulating red blood cells: methods of detection. In: Burnashev, Nail; Szepetowski, Pierre. NMDA Receptors. Hatfield, Hertfordshire, UK: Springer, 265-282. 1 | 2020-02-04 |
2018 |
Polina Petkova-Kirova, Laura Hertz, Asya Makhro, Jens Danielczok, Rick Huisjes, Esther Llaudet-Planas, Maria del Mar Mañú-Pereira, Joan-Luis Vives Corrons, Richard van Wijk, Anna Bogdanova, Lars Kaestner A Previously Unrecognized Ca2+-inhibited Nonselective Cation Channel in Red Blood Cells published pages: e146, ISSN: 2572-9241, DOI: 10.1097/HS9.0000000000000146 |
HemaSphere 2/5 | 2020-02-04 |
2019 |
Rick Huisjes, Asya Makhro, Esther Llaudet-Planas, Laura Hertz, Polina Petkova-Kirova, Liesbeth P Verhagen, Silvia Pignatelli, Minke AE Rab, Raymond M Schiffelers, Elena Seiler, Wouter W van Solinge, Joan-LLuis Vives Corrons, Maria Mañú-Pereira, Lars Kaestner, Anna Bogdanova, Richard van Wijk Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis published pages: haematol.2018.18, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.188151 |
Haematologica | 2020-02-04 |
2018 |
Lars Kaestner, Xijia Wang, Laura Hertz, Ingolf Bernhardt Voltage-Activated Ion Channels in Non-excitable Cells—A Viewpoint Regarding Their Physiological Justification published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00450 |
Frontiers in Physiology 9 | 2020-02-04 |
2017 |
Jens G. Danielczok, Emmanuel Terriac, Laura Hertz, Polina Petkova-Kirova, Franziska Lautenschläger, Matthias W. Laschke, Lars Kaestner Red Blood Cell Passage of Small Capillaries Is Associated with Transient Ca2+-mediated Adaptations published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2017.00979 |
Frontiers in Physiology 8 | 2020-02-04 |
2018 |
Alexander Kihm, Lars Kaestner, Christian Wagner, Stephan Quint Classification of red blood cell shapes in flow using outlier tolerant machine learning published pages: e1006278, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006278 |
PLOS Computational Biology 14/6 | 2020-02-04 |
2018 |
Giampaolo Minetti, Cesare Achilli, Cesare Perotti, Annarita Ciana Continuous Change in Membrane and Membrane-Skeleton Organization During Development From Proerythroblast to Senescent Red Blood Cell published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00286 |
Frontiers in Physiology 9 | 2020-02-04 |
2018 |
Elina Ovchynnikova, Francesca Aglialoro, Marieke von Lindern, Emile van den Akker The Shape Shifting Story of Reticulocyte Maturation published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00829 |
Frontiers in Physiology 9 | 2020-02-04 |
2019 |
Flueck, Joelle Leonie; Gallo, Alessandro; Moelijker, Nynke; Bogdanov, Nikolay; Bogdanova, Anna; Perret, Claudio Influence of Equimolar Doses of Beetroot Juice and Sodium Nitrate on Time Trial Performance in Handcycling published pages: 1642, ISSN: 2072-6643, DOI: 10.3929/ethz-b-000360090 |
Nutrients 11(7) | 2020-02-04 |
2018 |
Giustina M. Rotordam, Elisa Fermo, Nadine Becker, Wilma Barcellini, Andrea Brüggemann, Niels Fertig, Stéphane Egée, Markus Rapedius, Paola Bianchi, Lars Kaestner A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp published pages: haematol.2018.20, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.201160 |
Haematologica 103/10 | 2019-06-19 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RELEVANCE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "RELEVANCE" are provided by the European Opendata Portal: CORDIS opendata.