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AFib-TrainNet

EU Training Network on Novel Targets and Methods in Atrial Fibrillation

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

AFib-TrainNet project word cloud

Explore the words cloud of the AFib-TrainNet project. It provides you a very rough idea of what is the project "AFib-TrainNet" about.

afib fighting constitute electrophysiology origins leveraged medicine europeans expectancy population tools leaders therapy producing molecular sustained cardiac assume efficacy computational imbalance inform critical young scientists suffer experimental extra pharmacological limits atria permit electrical toxicities limited employing options pharmaceutical fibrillation cellular progression trainnet 2 human develops reflects fill biological industry instrumental threatening arrhythmias severe data proportions clinical fold ambition thereby sustenance beacon gap million prevalence medicines said arrhythmia af last life atrial healthy fresh occurring therapies drug underlying recapitulating models excellent endeavor accomplished search mechanisms ventricular epidemic

Project "AFib-TrainNet" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://afib.ku.dk/
Total cost	4˙101˙221 €
EC max contribution	4˙101˙221 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-09-01 to 2019-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	870˙245.00
2	UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Organization address address: Martinistrasse 52 city: HAMBURG postcode: 20251 website: www.uke.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	participant	747˙649.00
3	ACESION PHARMA APS ACESION PHARMA APS Organization address address: OLE MAALOES VEJ 3 city: KOBENHAVN postcode: 2200 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	580˙163.00
4	SIMULA RESEARCH LABORATORY AS SIMULA RESEARCH LABORATORY AS Organization address address: MARTIN LINGES VEI 17 city: FORNEBU postcode: 1364 website: www.simula.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (FORNEBU)	participant	572˙550.00
5	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	participant	546˙575.00
6	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	510˙748.00
7	CLYDE BIOSCIENCES LIMITED CLYDE BIOSCIENCES LIMITED Organization address address: BIOCITY SCOTLAND BO'NESS ROAD city: MOTHERWELL LANARKSHIRE postcode: ML1 5UH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MOTHERWELL LANARKSHIRE)	participant	273˙287.00
8	BEN-GURION UNIVERSITY OF THE NEGEV BEN-GURION UNIVERSITY OF THE NEGEV Organization address address: . city: BEER SHEVA postcode: 84105 website: www.bgu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (BEER SHEVA)	partner	0.00
9	Fondazione Cardiocentro Ticino Fondazione Cardiocentro Ticino Organization address address: Via Tesserete 48 city: Lugano postcode: 6900 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Lugano)	partner	0.00
10	OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN Organization address address: DR. IGNAZ SEIPEL-PLATZ 2 city: WIEN postcode: 1010 website: www.oeaw.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	partner	0.00
11	XENTION CAMBRIDGE XENTION CAMBRIDGE Organization address address: Iconix Park, London Road, Pampisford city: CAMBRIDGE postcode: CB22 3EG website: http://www.xention.com/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	partner	0.00

Map

Project objective

The AFib-TrainNet consortium will enable promising young scientists to become excellent research leaders of the future, capable of fighting the challenges that Atrial Fibrillation (AF) presents to the European population. AF is the most common sustained cardiac arrhythmia, occurring in between 1-2% of the general population. More than 6 million Europeans suffer from this arrhythmia and its prevalence is expected to increase by more than two-fold during the next 40 years due to increased life expectancy. Thus, AF is said to assume epidemic proportions. Current options for pharmacological therapy are limited by both low efficacy and side effects, including lifeâ€threatening ventricular arrhythmias and severe extra-cardiac toxicities. A very limited number of novel AF drug therapies have been introduced in the last 20 years. This imbalance reflects a gap in understanding in both how AF develops and how it can be treated, which thereby limits the development of new medicines. Our ambition with the AFib-TrainNet is to fill this gap by producing new knowledge, leading to critical insight into origins and mechanisms of sustenance of atrial fibrillation. We will accomplish this by developing novel experimental and computational models recapitulating human AF, and employing these models on two very promising atrial biological targets. Experimental models will be instrumental in improving the understanding AF’s underlying mechanisms, and will, along with clinical data, inform state-of-the-art computational models of human atrial electrophysiology. These new tools will permit fresh insight into the molecular, cellular and electrical mechanisms involved in the progression of healthy atria into an AF state. Our endeavor will deliver results which can be leveraged by the pharmaceutical industry to target AF drug development, and the work accomplished in AFib-TrainNet will thus constitute a beacon in the search for new AF medicine.

Deliverables

List of deliverables.
Periodical Scientific Reports (2)	Documents, reports	2020-02-28 08:16:54
Report on CDE activities (2)	Documents, reports	2020-02-28 08:16:54
Periodic report	Documents, reports	2020-02-28 08:16:54
Final report on training activities	Documents, reports	2020-02-28 08:16:54
Synergy meeting	Other	2020-02-28 08:16:54
Periodical training activities report (2)	Documents, reports	2020-02-28 08:16:54
CDE plan (3)	Documents, reports	2020-02-28 08:16:54
Career and Industry Day	Other	2020-02-28 08:16:54
15 PhD theses	Documents, reports	2020-02-28 08:16:54
Periodical training activities report (3)	Documents, reports	2020-02-28 08:16:54
Periodical Scientific Reports (3)	Documents, reports	2020-02-28 08:16:54
Open Research Data Pilot	Open Research Data Pilot	2020-02-28 08:16:54
Website	Websites, patent fillings, videos etc.	2020-02-28 08:16:53
Progress report	Documents, reports	2020-02-28 08:16:53
CDE plan (2)	Documents, reports	2020-02-28 08:16:53
List of recruited ESRs	Documents, reports	2020-02-28 08:16:53
Periodical training activities report (1)	Documents, reports	2020-02-28 08:16:53
Periodical Scientific Reports (1)	Documents, reports	2020-02-28 08:16:53
Report on CDE activities (1)	Documents, reports	2020-02-28 08:16:53
CDE plan (1)	Documents, reports	2020-02-28 08:16:53

Take a look to the deliverables list in detail: detailed list of AFib-TrainNet deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	L. Soattin; A. Lubberding; BH. Bentzen; T. Jespersen Adenosine 1 receptor activation plays a proarrhythmic role in rat atrium published pages: ii219-ii220, ISSN: , DOI:	Poster session abstract / EHRA EUROPACE - CARDIOSTIM 2017 Abstract supplement June 18-21,	2020-02-28
2019	Jeppe Egedal Kirchhoff, Mark Alexander Skarsfeldt, Kalai Mangai Muthukumarasamy, Rafel SimÃ³-Vicens, Sofia Hammami Bomholtz, Lea Abildgaard, Thomas Jespersen, Ulrik S. SÃ¸rensen, Morten Grunnet, Bo Hjorth Bentzen, Jonas Goldin Diness The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2019.00668	Frontiers in Pharmacology 10	2020-02-28
2019	Marta Lemme, Ingke Braren, Maksymilian Prondzynski, BÃ¼lent Aksehirlioglu, BÃ¤rbel M Ulmer, Mirja L Schulze, Djemail Ismaili, Christian Meyer, Arne Hansen, Torsten Christ, Marc D Lemoine, Thomas Eschenhagen Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvz245	Cardiovascular Research	2020-02-28
2019	Giommi A, Gurgel AR, Saxena P, Smith GL, Workman AJ An investigation of small conductance Ca2+-activated K+ current (ISK) in rabbit and human atrial cardiomyocytes published pages: 299-300, ISSN: , DOI:	Abstract / Proc Physiol Soc 43 (2019) PC041	2020-02-28
2018	Marta Lemme, BÃ¤rbel M. Ulmer, Marc D. Lemoine, Antonia T.L. Zech, Frederik Flenner, Ursula Ravens, Hermann Reichenspurner, Miriam Rol-Garcia, Godfrey Smith, Arne Hansen, Torsten Christ, Thomas Eschenhagen Atrial-like Engineered Heart Tissue: An InÂ Vitro Model of the Human Atrium published pages: 1378-1390, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.10.008	Stem Cell Reports 11/6	2020-02-28
2018	AndrÃ¡s HorvÃ¡th, Marc D. Lemoine, Alexandra LÃ¶ser, Ingra Mannhardt, Frederik Flenner, Ahmet Umur Uzun, Christiane Neuber, Kaja Breckwoldt, Arne Hansen, Evaldas Girdauskas, Hermann Reichenspurner, Stephan Willems, Norbert Jost, Erich Wettwer, Thomas Eschenhagen, Torsten Christ Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes published pages: 822-833, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.01.012	Stem Cell Reports 10/3	2020-02-28
2018	MÃ¡rcia Vagos, Ilsbeth G. M. van Herck, Joakim Sundnes, Hermenegild J. Arevalo, Andrew G. Edwards, Jussi T. KoivumÃ¤ki Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01221	Frontiers in Physiology 9	2020-02-28
2018	Arne van Hunnik, Stef Zeemering, Piotr Podziemski, Jorik Simons, Giulia Gatta, Laura Hannink, Bart Maesen, Marion Kuiper, Sander Verheule, Ulrich Schotten Stationary Atrial Fibrillation Properties in the Goat Do Not Entail Stable or Recurrent Conduction Patterns published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00947	Frontiers in Physiology 9	2020-02-28
2018	Rafel SimÃ³-Vicens, Sofia H. Bomholtz, Ulrik S. SÃ¸rensen, Bo H. Bentzen 2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2018.01409	Frontiers in Pharmacology 9	2020-02-28
2018	Rikke Buhl, Helena Carstensen, Eva Zander Hesselkilde, BjÃ¸rg Zinkernagel Klein, Karen Margrethe Hougaard, Kirsten Bomberg Ravn, Ameli Victoria Loft-Andersen, Merle Friederike Fenner, Christian Pipper, Thomas Jespersen Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters published pages: 1410-1419, ISSN: 0891-6640, DOI: 10.1111/jvim.15137	Journal of Veterinary Internal Medicine 32/4	2020-02-28

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