DrugsInPregnancy SIGNED
Effects of Medication Use in Pregnancy on Infant Neurodevelopment
Total Cost €
0EC-Contrib. €
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Project "DrugsInPregnancy" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITETET I OSLO
Organization address contact info |
| Coordinator Country | Norway [NO] |
| Project website | http://www.mn.uio.no/farmasi/english/research/projects/drug-in-pregnancy/ |
| Total cost | 1˙499˙439 € |
| EC max contribution | 1˙499˙439 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-09-01 to 2020-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITETET I OSLO | NO (OSLO) | coordinator | 1˙499˙439.00 |
Map
Project objective
Currently, thousands of pregnant women in the EU and worldwide are being increasingly prescribed medications for which we do not have sufficient information on fetal safety. I hypothesize that our current understanding of safety pharmacology is oversimplified and that medication prescribed during pregnancy may play an unrecognized role in the development of neurodevelopmental disorders. In this research proposal we have the unique opportunity to use a large population-based birth cohort including over 100 000 mother-child pairs and biological data to study how medications may act on the offspring. This offers novel and innovative pharmaceutical insight into the safety of medications. By linking several nationwide registries (National Prescription Data Base, Norwegian Patient Registry, Medical Birth Registry) to a population-based birth cohort (n=108 000) we specifically aim to 1) estimate the effect of prenatal exposure to psychotropics and analgesics on neurodevelopment in young children using a range of methodological approaches to strengthen causal inference. With these data made available, we will 2) determine whether fetal exposure to specific medications results in epigenetic events (i.e. changes in DNA methylation) in the child, and 3) determine whether such changes increase the risks of neurodevelopmental disorders in childhood. The recent availability of large scale human data, possibility of register linkages and genome-wide mapping of DNA methylation at affordable costs makes this research proposal now possible. The size and richness of data including over hundred thousand pregnancies and existence of biological material makes this project unique. The final outcome will be fundamentally new knowledge about how medications affect the developing unborn child and will open up new horizons and opportunities for future research in a new field of “pharmaco-epigenetics” and enhance our understanding of origins of neurodevelopmental disorders.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Jacqueline M Cohen, Mollie E Wood, Sonia Hernández-DÃaz, Eivind Ystrom, Hedvig Nordeng Paternal antidepressant use as a negative control for maternal use: assessing familial confounding on gestational length and anxiety traits in offspring published pages: 1665-1672, ISSN: 0300-5771, DOI: 10.1093/ije/dyz170 |
International Journal of Epidemiology 48/5 | 2020-04-15 |
| 2019 |
Michael Ceulemans, Angela Lupattelli, Hedvig Nordeng, Marina Odalovic, Michael Twigg, Veerle Foulon Women’s Beliefs About Medicines and Adherence to Pharmacotherapy in Pregnancy: Opportunities for Community Pharmacists published pages: 469-482, ISSN: 1381-6128, DOI: 10.2174/1381612825666190321110420 |
Current Pharmaceutical Design 25/5 | 2020-04-15 |
| 2019 |
Frank, Anna-Simone Josefine Thyroid hormone replacement therapy during pregnancy – Quantifying medication patterns and associated outcomes in the offspring published pages: , ISSN: , DOI: |
2020-04-15 | |
| 2019 |
Angela Lupattelli, Mollie E. Wood, Hedvig Nordeng Analyzing Missing Data in Perinatal Pharmacoepidemiology Research: Methodological Considerations to Limit the Risk of Bias published pages: 2477-2487, ISSN: 0149-2918, DOI: 10.1016/j.clinthera.2019.11.003 |
Clinical Therapeutics 41/12 | 2020-03-31 |
| 2019 |
Johanne N. Trønnes, Mollie Wood, Angela Lupattelli, Eivind Ystrom, Hedvig Nordeng Prenatal paracetamol exposure and neurodevelopmental outcomes in preschoolâ€aged children published pages: , ISSN: 0269-5022, DOI: 10.1111/ppe.12568 |
Paediatric and Perinatal Epidemiology | 2020-03-31 |
| 2019 |
Anna S. Frank, Angela Lupattelli, Ragnhild E. Brandlistuen, Hedvig Nordeng Maternal Thyroid Hormone Replacement Therapy Exposure and Language and Communication Skills of Offspring at 8 Years of Age published pages: e1912424, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2019.12424 |
JAMA Network Open 2/10 | 2020-03-31 |
| 2018 |
Anna S. Frank, Angela Lupattelli, David S. Matteson, Hedvig Nordeng Maternal use of thyroid hormone replacement therapy before, during, and after pregnancy: agreement between self-report and prescription records and group-based trajectory modeling of prescription patterns published pages: 1801-1816, ISSN: 1179-1349, DOI: 10.2147/clep.s175616 |
Clinical Epidemiology Volume 10 | 2020-03-31 |
| 2019 |
Anna S. Frank, Angela Lupattelli, David S. Matteson, Helle Margrete Meltzer, Hedvig Nordeng Thyroid hormone replacement therapy patterns in pregnant women and perinatal outcomes in the offspring published pages: 111-121, ISSN: 1053-8569, DOI: 10.1002/pds.4927 |
Pharmacoepidemiology and Drug Safety 29/1 | 2020-03-31 |
| 2019 |
Sarah Hjorth, Rebecca Bromley, Eivind Ystrom, Angela Lupattelli, Olav Spigset, Hedvig Nordeng Use and validity of child neurodevelopment outcome measures in studies on prenatal exposure to psychotropic and analgesic medications – A systematic review published pages: e0219778, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0219778 |
PLOS ONE 14/7 | 2020-03-31 |
| 2019 |
Angela Lupattelli, Christina D. Chambers, Gretchen Bandoli, Marte Handal, Svetlana Skurtveit, Hedvig Nordeng Association of Maternal Use of Benzodiazepines and Z-Hypnotics During Pregnancy With Motor and Communication Skills and Attention-Deficit/Hyperactivity Disorder Symptoms in Preschoolers published pages: e191435, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2019.1435 |
JAMA Network Open 2/4 | 2020-03-31 |
| 2019 |
Kristina Gervin, Lucas A. Salas, Kelly M. Bakulski, Menno C. van Zelm, Devin C. Koestler, John K. Wiencke, Liesbeth Duijts, Henriëtte A. Moll, Karl T. Kelsey, Michael S. Kobor, Robert Lyle, Brock C. Christensen, Janine F. Felix, Meaghan J. Jones Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-019-0717-y |
Clinical Epigenetics 11/1 | 2020-03-31 |
| 2019 |
Gro C. Havnen, Maria Bich-Thuy Truong, Mai-Linh H. Do, Kristine Heitmann, Lone Holst, Hedvig Nordeng Women’s perspectives on the management and consequences of hyperemesis gravidarum – a descriptive interview study published pages: 30-40, ISSN: 0281-3432, DOI: 10.1080/02813432.2019.1569424 |
Scandinavian Journal of Primary Health Care 37/1 | 2020-03-31 |
| 2020 |
Emil A Stoltenberg, Hedvig ME Nordeng, Eivind Ystrom, Sven O Samuelsen The cure model in perinatal epidemiology published pages: 96228022090409, ISSN: 0962-2802, DOI: 10.1177/0962280220904092 |
Statistical Methods in Medical Research | 2020-03-31 |
| 2016 |
Kristina Gervin, Christian Magnus Page, Hans Christian D. Aass, Michelle A. Jansen, Heidi Elisabeth Fjeldstad, Bettina Kulle Andreassen, Liesbeth Duijts, Joyce B. van Meurs, Menno C. van Zelm, Vincent W. Jaddoe, Hedvig Nordeng, Gunn Peggy Knudsen, Per Magnus, Wenche Nystad, Anne Cathrine Staff, Janine F. Felix, Robert Lyle Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition published pages: 690-698, ISSN: 1559-2294, DOI: 10.1080/15592294.2016.1214782 |
Epigenetics 11/9 | 2019-05-29 |
| 2017 |
Stefania Salvatore, Diana Domanska, Mollie Wood, Hedvig Nordeng, Geir Kjetil Sandve Complex patterns of concomitant medication use: A study among Norwegian women using paracetamol during pregnancy published pages: e0190101, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190101 |
PLOS ONE 12/12 | 2019-05-29 |
| 2016 |
Hedvig Nordeng Drug utilization in pregnant women published pages: 240-247, ISSN: , DOI: 10.1002/9781118949740.ch23 |
Drug Utilization Research: Methods and Applications | 2019-05-29 |
| 2017 |
Hedvig Nordeng, Angela Lupattelli, Mollie Wood Prenatal exposure to antidepressants and increased risk of psychiatric disorders published pages: j3950, ISSN: 0959-8138, DOI: 10.1136/bmj.j3950 |
BMJ | 2019-05-29 |
| 2018 |
Mollie E. Wood, Stavroula Chrysanthopoulou, Hedvig M.E. Nordeng, Kate L. Lapane The Impact of Nondifferential Exposure Misclassification on the Performance of Propensity Scores for Continuous and Binary Outcomes published pages: 1, ISSN: 0025-7079, DOI: 10.1097/MLR.0000000000000800 |
Medical Care | 2019-05-29 |
| 2017 |
Angela Lupattelli, Mollie Wood, Kate Lapane, Olav Spigset, Hedvig Nordeng Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from The Norwegian Mother and Child Cohort Study published pages: 1266-1276, ISSN: 1053-8569, DOI: 10.1002/pds.4286 |
Pharmacoepidemiology and Drug Safety 26/10 | 2019-05-29 |
| 2017 |
Eivind Ystrom, Kristin Gustavson, Ragnhild Eek Brandlistuen, Gun Peggy Knudsen, Per Magnus, Ezra Susser, George Davey Smith, Camilla Stoltenberg, Pål Surén, Siri E. Håberg, Mady Hornig, W. Ian Lipkin, Hedvig Nordeng, Ted Reichborn-Kjennerud Prenatal Exposure to Acetaminophen and Risk of ADHD published pages: e20163840, ISSN: 0031-4005, DOI: 10.1542/peds.2016-3840 |
Pediatrics 140/5 | 2019-05-29 |
| 2018 |
Anna S. Frank, Angela Lupattelli, Hedvig Nordeng Risk factors for discontinuation of thyroid hormone replacement therapy in early pregnancy: a study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway published pages: , ISSN: 0001-6349, DOI: 10.1111/aogs.13339 |
Acta Obstetricia et Gynecologica Scandinavica | 2019-05-29 |
| 2017 |
Gerd-Marie Eskerud Harris, Mollie Wood, Malin Eberhard-Gran, Christofer Lundqvist, Hedvig Nordeng Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine published pages: , ISSN: 1471-2393, DOI: 10.1186/s12884-017-1399-0 |
BMC Pregnancy and Childbirth 17/1 | 2019-05-29 |
| 2017 |
Johanne N. Trønnes, Angela Lupattelli, Hedvig Nordeng Safety profile of medication used during pregnancy: results of a multinational European study published pages: 802-811, ISSN: 1053-8569, DOI: 10.1002/pds.4213 |
Pharmacoepidemiology and Drug Safety 26/7 | 2019-05-29 |
| 2018 |
Mollie E. Wood, Kate L. Lapane, Marleen M.H.J. van Gelder, Dheeraj Rai, Hedvig M.E. Nordeng Making fair comparisons in pregnancy medication safety studies: An overview of advanced methods for confounding control published pages: 140-147, ISSN: 1053-8569, DOI: 10.1002/pds.4336 |
Pharmacoepidemiology and Drug Safety 27/2 | 2019-05-29 |
| 2017 |
Susan E. Andrade, Anick Bérard, Hedvig M.E. Nordeng, Mollie E. Wood, Marleen M.H.J. van Gelder, Sengwee Toh Administrative Claims Data Versus Augmented Pregnancy Data for the Study of Pharmaceutical Treatments in Pregnancy published pages: 106-116, ISSN: 2196-2995, DOI: 10.1007/s40471-017-0104-1 |
Current Epidemiology Reports 4/2 | 2019-05-29 |
| 2017 |
Kristina Gervin, Hedvig Nordeng, Eivind Ystrom, Ted Reichborn-Kjennerud, Robert Lyle Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-017-0376-9 |
Clinical Epigenetics 9/1 | 2019-05-29 |
| 2018 |
Gerd-Marie Eskerud Harris, Mollie Wood, Eivind Ystrom, Hedvig Nordeng Prenatal triptan exposure and neurodevelopmental outcomes in 5-year-old children: Follow-up from the Norwegian Mother and Child Cohort Study published pages: , ISSN: 0269-5022, DOI: 10.1111/ppe.12461 |
Paediatric and Perinatal Epidemiology | 2019-05-29 |
| 2017 |
Ragnhild E. Brandlistuen, Eivind Ystrom, Sonia Hernandez-Diaz, Svetlana Skurtveit, Randi Selmer, Marte Handal, Hedvig Nordeng Association of prenatal exposure to benzodiazepines and child internalizing problems: A sibling-controlled cohort study published pages: e0181042, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0181042 |
PLOS ONE 12/7 | 2019-05-29 |
| 2016 |
Olav Spigset, Hedvig Nordeng Safety of Psychotropic Drugs in Pregnancy and Breastfeeding published pages: 299-319, ISSN: , DOI: 10.1007/978-3-319-24741-0_15 |
Pharmacovigilance in Psychiatry | 2019-05-29 |
| 2018 |
Jacqueline M. Cohen, Mollie E. Wood, Sonia Hernandez-Diaz, Hedvig Nordeng Agreement between paternal self-reported medication use and records from a national prescription database published pages: 413-421, ISSN: 1053-8569, DOI: 10.1002/pds.4411 |
Pharmacoepidemiology and Drug Safety 27/4 | 2019-05-29 |
| 2018 |
Angela Lupattelli, Michael J Twigg, Ksenia Zagorodnikova, Myla E Moretti, Mariola Drozd, Alice Panchaud, Andre Rieutord, Romana Gjergja Juraski, Marina Odalovic, Debra Kennedy, Gorazd Rudolf, Herbert Juch, Hedvig Marie Egeland Nordeng Self-reported perinatal depressive symptoms and postnatal symptom severity after treatment with antidepressants in pregnancy: a cross-sectional study across 12 European countries using the Edinburgh Postnatal Depression Scale published pages: 655-669, ISSN: 1179-1349, DOI: 10.2147/CLEP.S156210 |
Clinical Epidemiology Volume 10 | 2019-04-03 |
| 2018 |
Angela Lupattelli, Elke Ronningen, Stine Kleppe Krogsrud, Hedvig Nordeng, Eivind Ystrom Personality and its relation to the use of alcohol and cigarettes during pregnancy: A multinational study published pages: 135910531877519, ISSN: 1359-1053, DOI: 10.1177/1359105318775194 |
Journal of Health Psychology | 2019-04-03 |
| 2018 |
Angela Lupattelli, Olav Spigset, Hedvig Nordeng Learning the effects of psychotropic drugs during pregnancy using real-world safety data: a paradigm shift toward modern pharmacovigilance published pages: 783-786, ISSN: 2210-7703, DOI: 10.1007/s11096-018-0672-2 |
International Journal of Clinical Pharmacy 40/4 | 2019-04-02 |
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